Results 51 to 60 of about 167,277 (315)

Securin Is Not Required for Chromosomal Stability in Human Cells [PDF]

, 2005
Abnormalities of chromosome number are frequently observed in cancers. The mechanisms regulating chromosome segregation in human cells are therefore of great interest.
Azofeifa, Bunz, Cahill, Ciosk, Cohen-Fix, Funabiki, Giménez-Abián, Gorr, Gruber, Haering, Hauf, Hauf, Huang, Jallepalli, Jürgen Cox, Katrin Pfleghaar, Losada, McGuinness, Mei, Michael R Speicher, Michor, Nasmyth, Olaf Stemmann, R. Scott Hawley, Ramos-Morales, Saez, Simone Heubes, Speicher, Stemmann, Stemmann, Uhlmann, Waizenegger, Zou   +32 more
core   +4 more sources

A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition

Cell Reports, 2016
To achieve chromosome segregation during mitosis, sister chromatids must undergo a dramatic change in their behavior to switch from balanced oscillations at the metaphase plate to directed poleward motion during anaphase.
Kuan-Chung Su, Zachary Barry, Nina Schweizer, Helder Maiato, Mark Bathe, Iain McPherson Cheeseman   +5 more
doaj   +1 more source

Bub1-mediated adaptation of the spindle checkpoint. [PDF]

PLoS Genetics, 2011
During cell division, the spindle checkpoint ensures accurate chromosome segregation by monitoring the kinetochore-microtubule interaction and delaying the onset of anaphase until each pair of sister chromosomes is properly attached to microtubules.
Greicy H Goto, Ashutosh Mishra, Rashid Abdulle, Clive A Slaughter, Katsumi Kitagawa   +4 more
doaj   +1 more source

The Long and Viscous Road: Uncovering Nuclear Diffusion Barriers in Closed Mitosis [PDF]

, 2014
During Saccharomyces cerevisiae closed mitosis, parental identity is sustained by the asymmetric segregation of ageing factors. Such asymmetry has been hypothesized to occur via diffusion barriers, constraining protein lateral exchange in cellular ...
Marquez-Lago, Tatiana T., Zavala, Eder
core   +4 more sources

Condensin Relocalization from Centromeres to Chromosome Arms Promotes Top2 Recruitment during Anaphase

Cell Reports, 2015
Condensin is a conserved chromosomal complex necessary to promote mitotic chromosome condensation and sister chromatid resolution during anaphase. Here, we report that yeast condensin binds to replicated centromere regions.
Joanne Leonard, Nicholas Sen, Raul Torres, Takashi Sutani, Adam Jarmuz, Katsuhiko Shirahige, Luis Aragón   +6 more
doaj   +1 more source

Modeling Dual Pathways for the Metazoan Spindle Assembly Checkpoint [PDF]

, 2006
Using computational modelling, we investigate mechanisms of signal transduction focusing on the spindle assembly checkpoint where a single unattached kinetochore is able to signal to prevent cell cycle progression.
Acquaviva, Castro, Clute, De Antoni, DeAntoni, Heinrich, Howell, Kraft, Lang, Luo, M. Howard, Mapelli, McEwen, Musacchio, Nasmyth, Nickell, Northrup, Pan, R. P. Sear, Rieder, Rieder, Rieder, Shah, Sironi, Sudakin, Tang, Tang, Vink, Wojcieszyn, Wollman   +29 more
core   +3 more sources

SiR‐XActin: A Fluorescent Probe for Imaging Actin Dynamics in Live Cells

Angewandte Chemie, EarlyView.
SiR‐XActin is a far‐red fluorescent probe for live‐cell imaging of actin that avoids genetic modification and minimizes disruption of actin dynamics, due to its lower binding affinity. Based on jasplakinolide‐like natural product hybrids and Si–Rhodamine, it offers photostable live‐cell no‐wash staining across cell types and microscopy techniques ...
Veselin Nasufovic, Julian Kompa, Halli L. Lindamood, Merle Blümke, Rayane Dibsy, Birgit Koch, Victoria Levario‐Diaz, Katharina Weber, Marlene Maager, Ekaterina Nomerotskaia, Arnaud Echard, Elisabetta Ada Cavalcanti‐Adam, Eric A. Vitriol, Hans‐Dieter Arndt, Kai Johnsson   +14 more
wiley   +2 more sources

Immunocytochemical localization of chromatin regions UV-microirradiated in S phase or anaphase : Evidence for a territorial organization of chromosomes during cell cycle of cultured Chinese hamster cells [PDF]

, 1983
Chinese hamster cells (M3-1 line) in S phase were laser-UV-microirradiated (λ, 257 nm) at a small site of the nucleus. Cells were fixed either immediately thereafter or in subsequent stages of the cell cycle, including prophase and metaphase.
Avivi, Bennett, Berns, Boveri, Boveri, Comings, Cornelis, Cornelis, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Cremer, Earnshaw, Gray, Hager, Hancock, Hancock, Hens, Laemmli, Rabl, Regan, Sakharov, Sedat, Sperling, Stack, Trosko, Vogel, Zorn   +33 more
core   +1 more source

Waiting for Anaphase

Cell, 2000
Although all the pieces of the puzzle may seem to be in place, there are still several key processes that have been widely posited but remain experimentally unverified. What attracts Mad2 to the kinetochore and what causes its release? Is it Mad1, as has been hypothesized from its apparent loss (along with Mad2) from the kinetochore after microtubule ...
Don W. Cleveland, Jagesh V. Shah
openaire   +3 more sources

Targeting Aurora Kinases as Essential Cell‐Cycle Regulators to Deliver Multi‐Stage Antimalarials Against Plasmodium Falciparum

Angewandte Chemie, EarlyView.
In this study, we repurposed human Aurora kinase‐specific inhibitors to identify potential antimalarial agents. Two inhibitors, hesperadin and TAE684, exhibited sub‐micromolar activity across multiple parasite stages, with hesperadin demonstrating significant potency and selectivity by specifically targeting PfArk1.
Henrico Langeveld, Keletso Maepa, Marché Maree, Jessica L. Thibaud, Nicolaas Salomane, Rosie Bridgwater, Mufuliat T. Famodimu, Luiz C. Godoy, Charisse Flerida A. Pasaje, Nonlawat Boonyalai, Mariana Laureano de Souza, Justin Fong, Tayla Rabie, Mariëtte van der Watt, Rensu P. Theart, Sonja Ghidelli‐Disse, Jacquin C. Niles, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael J. Delves, Kelly Chibale, Kathryn J. Wicht, Lauren B. Coulson, Lyn‐Marié Birkholtz   +23 more
wiley   +2 more sources