Results 51 to 60 of about 52,438 (267)
Nur1 dephosphorylation confers positive feedback to mitotic exit phosphatase activation in budding yeast. [PDF]
PLoS Genetics, 2015 Substrate dephosphorylation by the cyclin-dependent kinase (Cdk)-opposing phosphatase, Cdc14, is vital for many events during budding yeast mitotic exit.
Molly Godfrey +2 more
doaj +1 more source
eLife, 2020 During mitosis, the Spindle Assembly Checkpoint (SAC) maintains genome stability while also ensuring timely anaphase onset. To maintain genome stability, the SAC must be strong to delay anaphase even if just one chromosome is unattached, but for timely ...
Babhrubahan Roy +3 more
doaj +1 more source
TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution
Nature Communications, 2015 During mitosis, sister chromatids must be faithfully segregated to ensure that daughter cells receive one copy of each chromosome. However, following replication they often remain entangled.
R. Broderick +4 more
semanticscholar +1 more source
Spatial control of the anaphase-telophase transition [PDF]
Cell Cycle, 2014 The ultimate goal of mitosis is to physically separate the entire set of duplicated chromosomes in order to propagate the genetic information during cell division. The perpetuation of a faithful maintenance of the genome integrity can only be guaranteed by the existence of multiple cell cycle checkpoints.1 In particular, mitosis is a highly regulated ...
Olga Afonso, Irina Matos, Helder Maiato
openaire +3 more sources
NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis
Advanced Science, EarlyView.Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong +18 more
wiley +1 more source
Mitotic Exit Function of Polo-like Kinase Cdc5 Is Dependent on Sequential Activation by Cdk1
Cell Reports, 2016 To complete mitosis, Saccharomyces cerevisiae needs to activate the mitotic phosphatase Cdc14. Two pathways contribute to Cdc14 regulation: FEAR (Cdc14 early anaphase release) and MEN (mitotic exit network).
Jose-Antonio Rodriguez-Rodriguez +3 more
doaj +1 more source
Bub1 is a fission yeast kinetochore scaffold protein, and is sufficient to recruit other spindle checkpoint proteins to ectopic sites on chromosomes. [PDF]
PLoS ONE, 2007 The spindle checkpoint delays anaphase onset until all chromosomes have attached in a bi-polar manner to the mitotic spindle. Mad and Bub proteins are recruited to unattached kinetochores, and generate diffusible anaphase inhibitors.
Patricia E Rischitor +2 more
doaj +1 more source
Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans
Journal of Cell Biology, 2015 In early C. elegans embryos, the kinetochore-localized BUB- 1/BUB-3 complex promotes anaphase onset independently of its roles in spindle checkpoint signaling and chromosome alignment.
Taekyung Kim +5 more
semanticscholar +1 more source
Cell cycle: Oiling the gears of anaphase [PDF]
Current Biology, 1998 The anaphase-promoting complex (APC) or cyclosome directs the ubiquitination and destruction of proteins that control specific steps in mitosis. Recent studies show that APC activity requires WD40 domain proteins, and that one of these proteins is part of the checkpoint control that ensures accurate chromosome segregation.
Peter K. Jackson, Dieter A. Wolf
openaire +3 more sources
Advanced Science, EarlyView.Different from mitosis, the female meiosis undergoes asymmetric division that produces haploid oocytes and polar body, which is essential for retaining maternal components to support subsequent fertilization and embryo development. However, the underlying mechanisms are still largely unknown.
Yu Li +6 more
wiley +1 more source