MPO-ANCA-Associated Necrotizing Glomerulonephritis in Rheumatoid Arthritis; a Case Report and Review of Literature [PDF]
BACKGROUND: Renal involvement in rheumatoid arthritis (RA) is common and has a negative impact on patient survival. Only few cases have been reported of necrotizing glomerulonephritis (GN) associated with myeloperoxidase anti-neutrophil cytoplasmic ...
Carvalho, D +6 more
core +1 more source
ABSTRACT A 75‐year‐old man presented with an esophageal subepithelial lesion (SEL) measuring 2.5 cm, first identified over a decade ago. The patient was followed up regularly with computed tomography and endoscopy and remained asymptomatic since then. However, over the past year, the patient developed dysphagia, and endoscopic evaluation revealed that ...
Mai Fukuda +10 more
wiley +1 more source
Comparing outcomes of biopsy-proven anti-neutrophil cytoplasmic autoantibody–associated glomerulonephritis patients treated with cyclophosphamide in the 20th and 21st centuries: a 23-year study [PDF]
Background Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a multisystem autoimmune disorder associated with significant morbidity and mortality. Approximately 80–90% of patients have circulating ANCAs.
Dhaygude, Ajay +4 more
core +1 more source
Abstract Background Granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA) are distinct forms of antineutrophil cytoplasm antibody (ANCA)‐associated vasculitis (AAV). Increasing evidence suggests overlapping features, particularly in proteinase 3 (PR3)‐ANCA‐positive EGPA and GPA with eosinophilia.
Federica Pallotti +45 more
wiley +1 more source
P-ANCA vasculitis in a patient with Alpha-1-Antitrypsin deficiency : a possible mechanism [PDF]
Antineutrophil cytoplasmic antibody (ANCA) testing plays a critical role in the diagnosis and classification of vasculitis. These antibodies are strongly associated with Wegener's granulomatosis, microscopic polyangiitis and Churg-Strauss syndrome ...
Tuffaha, Ahmad
core
A hyperthyreosis kezelésének ritka mellékhatásai [PDF]
Absztrakt A szerzők hyperthyreosis miatt gondozott beteg esetét ismertetik, akinél a kezelés során propiltiouracil indukálta vasculitis igazolódott renalis érintettséggel, amely a ...
Gasztonyi, Beáta +3 more
core +1 more source
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu +7 more
wiley +1 more source
ELEVATED SERUM LEVELS OF TNF SOLUBLE RECEPTORS IN PATIENTS WITH POSITIVE ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODIES [PDF]
ANCA are found in various systemic vasculitis and are supposed to play a role in the pathogenesis of the disease, in cooperation with other factors such as cytokines.
DAYER, J.-M +3 more
core
An uncommon presentation of eosinophilic granulomatosis with polyangiitis: a case report [PDF]
INTRODUCTION: Eosinophilic granulomatosis with polyangiitis is a rare and potentially fatal disease if not readily diagnosed. Cerebral involvement is extremely rare and clinical presentation as hemorrhagic stroke is even rarer.
Andolina, G +5 more
core +2 more sources
ANCA-associated vasculitis: mission incomplete
Over the last decades, introduction of high-dose corticosteroids and immunosuppressive agents and later rituximab into the current algorithms for remission induction and maintenance treatment resulted in a tremendous improvement in the survival of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV).
Sergey V, Moiseev +2 more
openaire +3 more sources

