Results 11 to 20 of about 434,055 (399)
Androgens and Androgen Receptor Actions on Bone Health and Disease: From Androgen Deficiency to Androgen Therapy [PDF]
Cells, 2019 Androgens are not only essential for bone development but for the maintenance of bone mass. Therefore, conditions with androgen deficiency, such as male hypogonadism, androgen-insensitive syndromes, and prostate cancer with androgen deprivation therapy are strongly associated with bone loss and increased fracture risk.
Jia-Feng Chen +4 more
openaire +5 more sources
lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs. [PDF]
Nature, 2013 Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in physiological aspects of cell-type determination and tissue homeostasis, their potential involvement in regulated gene transcription programs remains rather poorly ...
Evans, Christopher P +11 more
core +2 more sources
The Impact of TRPM8 on Prostate Cancer Transcriptomic Dynamics [PDF]
CellsProstate cancer (PC) remains a significant health challenge, with androgen receptor (AR) signaling playing a pivotal role in its progression. This study investigates the expression and functional implications of the transient receptor potential ...
Swapna Asuthkar +7 more
doaj +2 more sources
Journal of Healthcare Engineering, 2022 The polycystic ovary syndrome (PCOS) is the disease featured by elevated levels of androgens, ovulatory dysfunction, and morphological abnormalities. At reproductive stage of women, the rate of PCOS occurrence is measured as 6–10% and the prevalence rate
Yalan Xu, J. Qiao
semanticscholar +1 more source
Frontiers in Physiology, 2021 We aimed to investigate the relationship between testosterone (T) levels and pregnancy outcomes in patients with tubal or male infertility at different times during in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles.
Zhiyan Chen +3 more
doaj +1 more source
Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications [PDF]
International Journal of Ophthalmology, 2021 Meibomian gland, the largest sebaceous gland of the body, is responsible for the biosynthesis of lipid layer of the tear film to prevent excessive evaporation.
Li-Xiang Wang, Ying-Ping Deng
doaj +1 more source
Definitions, 2020 Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus.
semanticscholar +1 more source
Androgens and the breast [PDF]
Breast Cancer Research, 2009 Androgens have important physiological effects in women while at the same time they may be implicated in breast cancer pathologies. However, data on the effects of androgens on mammary epithelial proliferation and/or breast cancer incidence are not in full agreement.
Carolyn A. Bondy +2 more
openaire +3 more sources
Firing patterns of gonadotropin-releasing hormone neurons are sculpted by their biologic state [PDF]
Royal Society Open Science, 2020 Gonadotropin-releasing hormone (GnRH) neurons form the final pathway for the central neuronal control of fertility. GnRH is released in pulses that vary in frequency in females, helping drive hormonal changes of the reproductive cycle.
Jonathon Penix +4 more
doaj +1 more source
F1000Research, 2016 Prostate cancer is a leading cause of cancer-related death in Western men. Our understanding of the genetic alterations associated with disease predisposition, development, progression, and therapy response is rapidly improving, at least in part, owing ...
Angela C. Pine +3 more
doaj +1 more source