Results 11 to 20 of about 378,224 (340)

Advances in genetics: widening our understanding of prostate cancer [version 1; referees: 2 approved]

F1000Research, 2016
Prostate cancer is a leading cause of cancer-related death in Western men. Our understanding of the genetic alterations associated with disease predisposition, development, progression, and therapy response is rapidly improving, at least in part, owing ...
Angela C. Pine, Flavia F. Fioretti, Greg N. Brooke, Charlotte L. Bevan   +3 more
doaj   +1 more source

Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen. [PDF]

, 1993
Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone receptor superfamily. In this work the effect of androgens and antiandrogens on the expression of the human androgen receptor (hAR) in prostate and breast ...
Blasschke, Dorothea, Hermeking, Heiko, Herzinger, Thomas, Hörz, Wolfram, Wolf, Dieter A.   +4 more
core   +1 more source

Behavioral analysis of genetically modified mice indicates essential roles of neurosteroidal estrogen

Frontiers in Endocrinology, 2011
Brain aromatase is expressed only in the nerve cells of specific brain regions with a transient peak at the neonatal period when sexual behaviors become organized. Aromatase knockout (ArKO) mouse, generated to give light on the physiological functions of
Nobuhiro eHarada, Toru eWakatsuki, Shin-ichiro eHonda   +2 more
doaj   +1 more source

Role of sex and sex hormones in PD-L1 expression in NSCLC: clinical and therapeutic implications

Frontiers in Oncology, 2023
Currently, immunotherapy based on PD-1/PD-L1 pathway blockade has improved survival of non-small cell lung cancer (NSCLC) patients. However, differential responses have been observed by sex, where men appear to respond better than women.
Vianey Rodriguez-Lara, Giovanny Soca-Chafre, Maria Rosa Avila-Costa, Juan Jose Juarez-Vignon Whaley, Jeronimo Rafael Rodriguez-Cid, José Luis Ordoñez-Librado, Emma Rodriguez-Maldonado, Nallely A. Heredia-Jara   +7 more
doaj   +1 more source

Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells [PDF]

, 2013
The development and growth of prostate cancer is dependent on androgens; thus, the identification of androgen-regulated genes in prostate cancer cells is vital for defining the mechanisms of prostate cancer development and progression and developing new ...
Brinkmann, Chen, Ciara O'Hanlon-Brown, Claessens, Cleutjens, Cook, Cunha, Dai, Devos, Feldman, Greg N Brooke, Gregory, Haelens, Haelens, Ham, Heinlein, Jonathan Waxman, Laki Buluwela, Lin, Lu, Luke, Lund, Massie, Massie, Ngan, Nird  , Rennie, Rowling, Shang, Shen, Silvia Ottaviani, Simak Ali, Song, Sreekumar, Verrijdt, Wang, Yu   +36 more
core   +1 more source

Hedgehog Signalling in Androgen Independent Prostate Cancer [PDF]

, 2008
Objectives: Androgen-deprivation therapy effectively shrinks hormone-naïve prostate cancer, both in the prostate and at sites of distant metastasis.
Bisson, Isabelle, Ktori, Elena, McFaul, Siobhan, Oliver, R. Tim D, Price, Anna M., Prowse, David M., Purkis, Patricia E., Shaw, Greg   +7 more
core   +1 more source

Mitogen Activated Protein kinase signal transduction pathways in the prostate

Cell Communication and Signaling, 2004
The biochemistry of the mitogen activated protein kinases ERK, JNK, and p38 have been studied in prostate physiology in an attempt to elucidate novel mechanisms and pathways for the treatment of prostatic disease.
Koul Sweaty, Maroni Paul D, Meacham Randall B, Koul Hari K   +3 more
doaj   +1 more source

Normal Reference Ranges of Serum Testosterone and Gonadotropins in Thai Fertile Men: A Cross-sectional Study in a Single Tertiary Center

Journal of Health Science and Medical Research (JHSMR), 2021
Objective: To identify the normal reference ranges of serum testosterone and gonadotropins in Thai fertile men, compare these levels among different age groups, and assess their relationships with body mass index (BMI). Material and Methods: One hundred
Thakorn Pruktanakul, Kittithat Taemkaew, Tippawan Liabsuetrakul, Rattana Leelawattana, Noppadol Kietsiriroje   +4 more
doaj   +1 more source

WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics [PDF]

, 2009
Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in non-adherent cultures.
A de la Taille, A Glinka, A van Bokhoven, AA George, AP Verhagen, AS Waller, AT Collins, AT Collins, AT Collins, B Hoang, B Mao, BA Reynolds, C Lo Celso, C Wissmann, CC Carson 3rd, CI Truica, CL Hall, CL Hall, D Beier, D Bonnet, D Masiello, D Mizrak, DA Lawson, David M Prowse, DK Singla, DL Hudson, DL Hudson, DP Petrylak, DR Chesire, EM Hurt, G Dontu, G Gu, G Shaw, G Shaw, GD Richardson, GJ van Leenders, GL Shaw, GN Thalmann, H Clevers, H Li, H Zhu, HF English, Isabelle Bisson, IV Litvinov, IV Litvinov, J Miki, JA Schalken, JE Visvader, JM Adams, KD Bunting, KG Leong, L Adam, L Patrawala, L Patrawala, L Patrawala, L Ricci-Vitiani, L Vezzoni, L Xin, L Xin, LE Pascal, LG Wang, M Al-Hajj, M Locke, M Verras, MJ Linja, MS Chen, MS Wicha, N Uchida, PN Kelly, RI Bhatt, S Signoretti, S Weiss, S Zhou, SI Hwang, SK Singh, SM Janes, SV Shmelkov, T Hara, T Nikolova, T Reya, WJ Huss, Y Katoh, Y Lu   +82 more
core   +1 more source

One Tool for Many Jobs: Divergent and Conserved Actions of Androgen Signaling in Male Internal Reproductive Tract and External Genitalia

Frontiers in Endocrinology, 2022
In the 1940s, Alfred Jost demonstrated the necessity of testicular secretions, particularly androgens, for male internal and external genitalia differentiation.
Ciro M. Amato, Humphrey H-C. Yao, Fei Zhao   +2 more
doaj   +1 more source