Results 11 to 20 of about 169,598 (149)

Role of sex and sex hormones in PD-L1 expression in NSCLC: clinical and therapeutic implications

Frontiers in Oncology, 2023
Currently, immunotherapy based on PD-1/PD-L1 pathway blockade has improved survival of non-small cell lung cancer (NSCLC) patients. However, differential responses have been observed by sex, where men appear to respond better than women.
Vianey Rodriguez-Lara, Giovanny Soca-Chafre, Maria Rosa Avila-Costa, Juan Jose Juarez-Vignon Whaley, Jeronimo Rafael Rodriguez-Cid, José Luis Ordoñez-Librado, Emma Rodriguez-Maldonado, Nallely A. Heredia-Jara   +7 more
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Mitogen Activated Protein kinase signal transduction pathways in the prostate

Cell Communication and Signaling, 2004
The biochemistry of the mitogen activated protein kinases ERK, JNK, and p38 have been studied in prostate physiology in an attempt to elucidate novel mechanisms and pathways for the treatment of prostatic disease.
Koul Sweaty, Maroni Paul D, Meacham Randall B, Koul Hari K   +3 more
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Normal Reference Ranges of Serum Testosterone and Gonadotropins in Thai Fertile Men: A Cross-sectional Study in a Single Tertiary Center

Journal of Health Science and Medical Research (JHSMR), 2021
Objective: To identify the normal reference ranges of serum testosterone and gonadotropins in Thai fertile men, compare these levels among different age groups, and assess their relationships with body mass index (BMI). Material and Methods: One hundred
Thakorn Pruktanakul, Kittithat Taemkaew, Tippawan Liabsuetrakul, Rattana Leelawattana, Noppadol Kietsiriroje   +4 more
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One Tool for Many Jobs: Divergent and Conserved Actions of Androgen Signaling in Male Internal Reproductive Tract and External Genitalia

Frontiers in Endocrinology, 2022
In the 1940s, Alfred Jost demonstrated the necessity of testicular secretions, particularly androgens, for male internal and external genitalia differentiation.
Ciro M. Amato, Humphrey H-C. Yao, Fei Zhao   +2 more
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Animal models of polycystic ovary syndrome: A review of hormone‐induced rodent models focused on hypothalamus‐pituitary‐ovary axis and neuropeptides

Reproductive Medicine and Biology, 2019
Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women of reproductive age and a major cause of infertility; however, the pathophysiology of this syndrome is not fully understood.
Satoko Osuka, Natsuki Nakanishi, Tomohiko Murase, Tomoko Nakamura, Maki Goto, Akira Iwase, Fumitaka Kikkawa   +6 more
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Fragile X Mental Retardation Protein Mediates the Effects of Androgen on Hippocampal PSD95 Expression and Dendritic Spines Density/Morphology and Autism-Like Behaviors Through miR-125a

Frontiers in Cellular Neuroscience, 2022
Dysregulated synaptic plasticity is a key feature of neurodevelopmental disorders, including autism. This study investigated whether Fragile X mental retardation protein (FMRP), a selective RNA-binding protein that regulates synaptic protein expression ...
Huan Chen, Huan Chen, Dan Qiao, Dan Qiao, Chang Wang, Chang Wang, Chang Wang, Bohan Zhang, Bohan Zhang, Zhao Wang, Zhao Wang, Longmei Tang, Yibo Wang, Ran Zhang, Yizhou Zhang, Yizhou Zhang, Yizhou Zhang, Leigang Song, Leigang Song, Hongchun Zuo, Hongchun Zuo, Fangzhen Guo, Fangzhen Guo, Xia Wang, Sha Li, Sha Li, Sha Li, Huixian Cui, Huixian Cui, Huixian Cui   +29 more
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Divergent Associations Between Serum Androgens and Ovarian Reserve Markers Revealed in Patients With Polycystic Ovary Syndrome

Frontiers in Endocrinology, 2022
BackgroundThe role of excess androgen in ovarian reserve remains unclear in patients with polycystic ovary syndrome (PCOS). Our study highlights the associations of serum androgen levels and ovarian reserve markers in PCOS and non-PCOS women ...
Youran Li, Youran Li, Yanhong Zhai, Yanhong Zhai, Lin Li, Yifan Lu, Yifan Lu, Shaofei Su, Ying Liu, Ying Liu, Zhengwen Xu, Zhengwen Xu, Mingwei Xin, Qiaoli Zhang, Zheng Cao, Zheng Cao   +15 more
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Low Serum Dehydroepiandrosterone Is Associated With Diabetic Kidney Disease in Men With Type 2 Diabetes Mellitus

Frontiers in Endocrinology, 2022
BackgroundThe associations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) with diabetic kidney disease (DKD) remained unclear. Thus, this cross-sectional study aimed to explore the associations of DHEA and DHEAS with the risk
Xinxin Zhang, Jinfeng Xiao, Xin Li, Jingqiu Cui, Kunling Wang, Qing He, Ming Liu, Ming Liu, Ming Liu   +8 more
doaj   +1 more source

Factors that influence the androgen receptor cistrome in benign and malignant prostate cells

Molecular Oncology, 2019
The androgen receptor (AR) plays key roles in the development of prostate tissue and the development and progression of prostate cancer (PC). AR guides cytodifferentiation and homeostasis in benign luminal epithelial cells; however, in PC, AR instead ...
Ben T. Copeland, Juan Du, Sumanta K. Pal, Jeremy O. Jones   +3 more
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Contextual modulation of social and endocrine correlates of fitness: insights from the life history of a sex changing fish

Frontiers in Neuroscience, 2015
Steroid hormones are critical regulators of reproductive life history, and the steroid sensitive traits (morphology, behavior, physiology) associated with particular life history stages can have substantial fitness consequences for an organism. Hormones,
Devaleena S Pradhan, Devaleena S Pradhan, Tessa K Solomon-Lane, Matthew Scott Grober, Matthew Scott Grober   +4 more
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