Results 21 to 30 of about 378,224 (340)

Androgens and Hypertension in Men and Women: a Unifying View. [PDF]

, 2017
This review was designed to revaluate the androgen role on the mechanisms of hypertension and cardiovascular risks in both men and women. Sex steroids are involved in the regulation of blood pressure, but pathophysiological mechanism is not well ...
Carmina, E. 4., Gnessi, Lucio, Lanzolla, Giulia, Moretti, Costanzo, Moretti, Marta   +4 more
core   +1 more source

The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor [PDF]

, 2005
Prostate cancer is the second most common male malignancy in the western world an increasing incidence in an ageing population. Treatment of advanced prostate cancer relies on androgen deprivation.
Bakin RE, Buchanan G, Chang C, Davies MA, Malik SN, Marcelli M, Taplin ME, Thakkar H   +7 more
core   +1 more source

Androgens and Androgen Receptor Actions on Bone Health and Disease: From Androgen Deficiency to Androgen Therapy [PDF]

Cells, 2019
Androgens are not only essential for bone development but for the maintenance of bone mass. Therefore, conditions with androgen deficiency, such as male hypogonadism, androgen-insensitive syndromes, and prostate cancer with androgen deprivation therapy are strongly associated with bone loss and increased fracture risk.
Jia-Feng Chen, Pei-Wen Lin, Yi-Ru Tsai, Yi-Chien Yang, Hong-Yo Kang   +4 more
openaire   +4 more sources

Contribution of recent transgenic models and transcriptional profiling studies to our understanding of the mechanisms by which androgens control spermatogenesis [PDF]

, 2008
Publisher ...
Claessens, Frank, De Gendt, Karel, Denolet, Evi, Saunders, Philippa T K, Sharpe, Richard, Swinnen, Johannes V, Verhoeven, Guido, Willems, Ariane   +7 more
core   +1 more source

Animal models of polycystic ovary syndrome: A review of hormone‐induced rodent models focused on hypothalamus‐pituitary‐ovary axis and neuropeptides

Reproductive Medicine and Biology, 2019
Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women of reproductive age and a major cause of infertility; however, the pathophysiology of this syndrome is not fully understood.
Satoko Osuka, Natsuki Nakanishi, Tomohiko Murase, Tomoko Nakamura, Maki Goto, Akira Iwase, Fumitaka Kikkawa   +6 more
doaj   +1 more source

Fragile X Mental Retardation Protein Mediates the Effects of Androgen on Hippocampal PSD95 Expression and Dendritic Spines Density/Morphology and Autism-Like Behaviors Through miR-125a

Frontiers in Cellular Neuroscience, 2022
Dysregulated synaptic plasticity is a key feature of neurodevelopmental disorders, including autism. This study investigated whether Fragile X mental retardation protein (FMRP), a selective RNA-binding protein that regulates synaptic protein expression ...
Huan Chen, Huan Chen, Dan Qiao, Dan Qiao, Chang Wang, Chang Wang, Chang Wang, Bohan Zhang, Bohan Zhang, Zhao Wang, Zhao Wang, Longmei Tang, Yibo Wang, Ran Zhang, Yizhou Zhang, Yizhou Zhang, Yizhou Zhang, Leigang Song, Leigang Song, Hongchun Zuo, Hongchun Zuo, Fangzhen Guo, Fangzhen Guo, Xia Wang, Sha Li, Sha Li, Sha Li, Huixian Cui, Huixian Cui, Huixian Cui   +29 more
doaj   +1 more source

Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors [PDF]

, 2010
Follicle stimulating hormone (FSH) and androgen act to stimulate and maintain spermatogenesis. FSH acts directly on the Sertoli cells to stimulate germ cell number and acts indirectly to increase androgen production by the Leydig cells.
Abel, M.H., De Gendt, K., Monteiro, A., O'Shaughnessy, P.J., Verhoeven, G.   +4 more
core   +2 more sources

The impact of point mutations in the human androgen receptor : classification of mutations on the basis of transcriptional activity [PDF]

, 2011
Peer reviewedPublisher ...
A Godoy, A Haelens, A Monge, AN Vis, AO Brinkmann, B Cinar, B Gottlieb, B He, B He, B He, B Tiwary, BA Evans, C Cai, CA Berrevoets, CA Heinlein, Colin W. Hay, CT Kesler, CT Wu, D Ricketson, DJ Lamb, EB Askew, EP Gelmann, ER Hyytinen, G Buchanan, G Chen, G Verrijdt, GN Brooke, GP Reddy, H Faus, H Takahashi, HI Scher, HJ Dubbink, HT Bruggenwirth, I Ahrens-Fath, Iain J. McEwan, IJ McEwan, J Brodie, J Duff, J Edwards, J Geller, J Reid, J Tan, J Veldscholte, JA Locke, JD Wilson, Jean-Marc A. Lobaccaro, K Evaul, K Haapala, KB Cleutjens, KE Knudsen, KH Chang, KK Waltering, KM Lakshman, LJ Blok, M Fu, M Jagla, M Marcelli, M Sun, M Uemura, M Welsh, ME Baker, ME Taplin, ME Taplin, ME Taplin, MJ Linja, MM Centenera, MM Shen, N Mononen, OA O'Mahony, PA Watson, PE de Ruiter, Q Wang, R Betney, R Chenna, R Hu, R Schule, RJ Andersen, S Baron, S Haile, S Koochekpour, SM Dehm, SM Dehm, SM Powell, SS Dutt, SS Taneja, ST Page, TH Li, TM Tanner, W Li, Y Chen, Y Gluzman, Y Niu, Y Niu, Y Ogino, YD Li, Z Guo   +95 more
core   +9 more sources

Divergent Associations Between Serum Androgens and Ovarian Reserve Markers Revealed in Patients With Polycystic Ovary Syndrome

Frontiers in Endocrinology, 2022
BackgroundThe role of excess androgen in ovarian reserve remains unclear in patients with polycystic ovary syndrome (PCOS). Our study highlights the associations of serum androgen levels and ovarian reserve markers in PCOS and non-PCOS women ...
Youran Li, Youran Li, Yanhong Zhai, Yanhong Zhai, Lin Li, Yifan Lu, Yifan Lu, Shaofei Su, Ying Liu, Ying Liu, Zhengwen Xu, Zhengwen Xu, Mingwei Xin, Qiaoli Zhang, Zheng Cao, Zheng Cao   +15 more
doaj   +1 more source

International study into the use of intermittent hormone therapy in the treatment of carcinoma of the prostate : A meta-analysis of 1446 patients [PDF]

, 2007
OBJECTIVE: To review pooled phase II data to identify features of different regimens of intermittent hormone therapy (IHT), developed to reduce the morbidity of treating metastatic prostate cancer, and which carries a theoretical advantage of delaying ...
Cuzick, Jack, Goldenberg, S. Larry, Oliver, Tim, Prowse, David M., Shaw, Greg L., Spry, Nigel A., Wilson, Peter   +6 more
core   +1 more source