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In the 1940s, Alfred Jost demonstrated the necessity of testicular secretions, particularly androgens, for male internal and external genitalia differentiation.
Ciro M. Amato+2 more
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Updates on androgen replacement therapy and lower urinary tract symptoms: a narrative review
Lower urinary tract symptoms (LUTS) are caused by higher tension at the bladder neck level (due to fibrosis or stiffness) or benign prostatic hyperplasia, which causes static obstruction of the bladder outlet. Both forms cause a group of symptoms such as
Raed M. Al-Zoubi+6 more
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We aimed to investigate the relationship between testosterone (T) levels and pregnancy outcomes in patients with tubal or male infertility at different times during in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles.
Zhiyan Chen+3 more
doaj +1 more source
Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications [PDF]
Meibomian gland, the largest sebaceous gland of the body, is responsible for the biosynthesis of lipid layer of the tear film to prevent excessive evaporation.
Li-Xiang Wang, Ying-Ping Deng
doaj +1 more source
Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus.
semanticscholar +1 more source
Androgens and the breast [PDF]
Androgens have important physiological effects in women while at the same time they may be implicated in breast cancer pathologies. However, data on the effects of androgens on mammary epithelial proliferation and/or breast cancer incidence are not in full agreement.
Carolyn A. Bondy+2 more
openaire +3 more sources
Firing patterns of gonadotropin-releasing hormone neurons are sculpted by their biologic state [PDF]
Gonadotropin-releasing hormone (GnRH) neurons form the final pathway for the central neuronal control of fertility. GnRH is released in pulses that vary in frequency in females, helping drive hormonal changes of the reproductive cycle.
Jonathon Penix+4 more
doaj +1 more source
Prostate cancer is a leading cause of cancer-related death in Western men. Our understanding of the genetic alterations associated with disease predisposition, development, progression, and therapy response is rapidly improving, at least in part, owing ...
Angela C. Pine+3 more
doaj +1 more source
Androgen sensitivity gateway to COVID‐19 disease severity
In this communication, we present arguments for androgen sensitivity as a likely determinant of COVID‐19 disease severity. The androgen sensitivity model explains why males are more likely to develop severe symptoms while children are ostensibly ...
C. Wambier+7 more
semanticscholar +1 more source
The Role of Testosterone in Menopause Management: A Review of Literature
Background: Despite the lack of approved testosterone formulations for women in most countries, testosterone therapy is still being offered to women worldwide.
Eileen M. Manalo+2 more
doaj +1 more source