Androgen sensitivity gateway to COVID‐19 disease severity
Drug development research (Print), 2020 In this communication, we present arguments for androgen sensitivity as a likely determinant of COVID‐19 disease severity. The androgen sensitivity model explains why males are more likely to develop severe symptoms while children are ostensibly ...
C. Wambier +7 more
semanticscholar +1 more source
The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 2: androgen-receptor cofactors and bypass pathways [PDF]
, 2005 Prostate cancer is the second leading cause of cancer related deaths in men from the western world. Treatment of prostate cancer has relied on androgen deprivation therapy for the past 50 years.
Bakin RE +9 more
core +4 more sources
The Role of Testosterone in Menopause Management: A Review of Literature
Fertility & Reproduction, 2021 Background: Despite the lack of approved testosterone formulations for women in most countries, testosterone therapy is still being offered to women worldwide.
Eileen M. Manalo +2 more
doaj +1 more source
Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen. [PDF]
, 1993 Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone receptor superfamily. In this work the effect of androgens and antiandrogens on the expression of the human androgen receptor (hAR) in prostate and breast ...
Blasschke, Dorothea +4 more
core +1 more source
Androgen insensitivity syndrome.
Baillière's Clinical Endocrinology and Metabolism, 2019 In a relatively short period of time, understanding of the fundamental causes of androgen insensitivity syndromes has improved dramatically. This has been brought about by the combination of several disciplines, including endocrinology, genetics ...
H. Scharnagl +169 more
semanticscholar +1 more source
Androgen Receptor Signaling Pathway in Prostate Cancer: From Genetics to Clinical Applications
Cells, 2020 Around 80–90% of prostate cancer (PCa) cases are dependent on androgens at initial diagnosis; hence, androgen ablation therapy directed toward a reduction in serum androgens and the inhibition of androgen receptor (AR) is generally the first therapy ...
G. Aurilio +9 more
semanticscholar +1 more source
Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells [PDF]
, 2013 The development and growth of prostate cancer is dependent on androgens; thus, the identification of androgen-regulated genes in prostate cancer cells is vital for defining the mechanisms of prostate cancer development and progression and developing new ...
Brinkmann +36 more
core +1 more source
Hedgehog Signalling in Androgen Independent Prostate Cancer [PDF]
, 2008 Objectives: Androgen-deprivation therapy effectively shrinks hormone-naïve prostate cancer, both in the prostate and at sites of distant metastasis.
Bisson, Isabelle +7 more
core +1 more source
Journal of Clinical Endocrinology and Metabolism, 2010 OBJECTIVE Our objective was to update the guidelines for the evaluation and treatment of androgen deficiency syndromes in adult men published previously in 2006.
S. Bhasin +6 more
semanticscholar +1 more source
A potential biomarker of androgen exposure in European bullhead (Cottus sp.) kidney [PDF]
Fish Physiology and Biochemistry 39, 3 (2013) 573-580, 2014 The aim of this study was to identify a signal that could be used as an androgen exposure indicator in the European bullhead (Cottus sp.). For this purpose, the ultra-structure of the kidney was characterized to identify normal structure of this organ, and histological changes previously described in the kidney of breeding male bullheads were ...
arxiv +1 more source