Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution
International Journal of Cancer, EarlyView.Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano +6 more
wiley +1 more source
Androgen receptors in the neo-natal period: evidence for some “physiological” androgen resistance in male infants [PDF]
, 1981 C. Sultan +4 more
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Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, EarlyView.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
F1000ResearchBackground: Prostate cancer is a disease that occurs in men aged more than 50 years. In Iraq, 8.89 men per 100,000 population suffer from prostate cancer, with the incidence being 14,016 cases and mortality being 6,367 cases.
Hany Akeel Al-Hussaniy +2 more
doaj
Comparison of androgen receptor in male and female rat submandibular glands.
, 1985 Yuko Ohara +5 more
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Suppression of Steroid Receptor‐Chromatin Interaction by Inhibitors Present in Ammonium Sulfate‐Fractionated Rat Testicular Androgen Receptor Preparations [PDF]
, 1987 Yu‐Hui Tsai
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Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture
International Journal of Cancer, EarlyView.Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert +3 more
wiley +1 more source
Androgen receptor in serially subcultured human endometrial fibroblasts.
, 1980 Hiroshi Wakimoto +2 more
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ANDROGEN INSENSITIVITY (AI) IN 43 PATIENTS: CLASSIFICATION BASED ON CLINICAL AND ANDROGEN RECEPTORS (AR) PHENOTYPES [PDF]
, 1986 Ieuan A. Hughes, Bronwyn A. Evans
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International Journal of Cancer, EarlyView.Abstract Liquid biopsy can revolutionize cancer patient management as repeated sampling allows real‐time monitoring of disease progression and response to treatment. The circulating transcriptome represents a rich source of potential cancer biomarkers, including coding and non‐coding RNAs.
Mengqian Li +7 more
wiley +1 more source