Technology in Cancer Research & Treatment, 2021 Triple-negative breast cancer is a heterogeneous disease with different molecular and histological subtypes. The Androgen receptor is expressed in a portion of triple-negative breast cancer cases and the activation of the androgen receptor pathway is ...
Taobo Hu +3 more
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Androgen Receptor Phosphorylation [PDF]
Endocrine Research, 1993 Phosphorylation of transcription factors plays an important role in regulation of gene expression. DNA-binding, transactivation activity, and subcellular trafficking of specific transcription factors have been shown to be regulated by phosphorylation/dephosphorylation.
Leen J. Blok +2 more
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Androgen receptor accelerates premature senescence of human dermal papilla cells in association with DNA damage. [PDF]
PLoS ONE, 2013 The dermal papilla, located in the hair follicle, expresses androgen receptor and plays an important role in hair growth. Androgen/Androgen receptor actions have been implicated in the pathogenesis of androgenetic alopecia, but the exact mechanism is not
Yi-Chien Yang +5 more
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Filamin A cooperates with the androgen receptor in preventing skeletal muscle senescence
Cell Death Discovery, 2023 Aging induces a slow and progressive decrease in muscle mass and function, causing sarcopenia. Androgens control muscle trophism and exert important anabolic functions through the binding to the androgen receptor.
Marzia Di Donato +7 more
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Androgen receptor status is a prognostic marker in non-basal triple negative breast cancers and determines novel therapeutic options. [PDF]
PLoS ONE, 2014 Triple negative breast cancers are a heterogeneous group of tumors characterized by poor patient survival and lack of targeted therapeutics. Androgen receptor has been associated with triple negative breast cancer pathogenesis, but its role in the ...
Pierluigi Gasparini +13 more
doaj +1 more source
Does changing androgen receptor status during prostate cancer development impact upon cholesterol homeostasis? [PDF]
PLoS ONE, 2013 Recent evidence associates prostate cancer with high cholesterol levels, with cholesterol being an important raw material for cell-growth. Within the cell, cholesterol homeostasis is maintained by two master transcription factors: sterol-regulatory ...
James Robert Krycer, Andrew John Brown
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Pakistan Armed Forces Medical Journal, 2021 Objective: To determine the frequency of immunohistochemical expression of androgen receptor in triple negative breast carcinoma. Study Design: Cross sectional study.
Amna Ameer +3 more
doaj +3 more sources
The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor [PDF]
, 2005 Prostate cancer is the second most common male malignancy in the western world an increasing incidence in an ageing population. Treatment of advanced prostate cancer relies on androgen deprivation.
Bakin RE +7 more
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Genetics Research, 2023 Objective. The purpose of our work was to explore the association of mutations in the androgen receptor gene and copy numbers of the androgen-receptor silk protein A complex with glutathione-S-transferases T1 and M1 in prostate cancer patients. Materials
Yan Zhang +4 more
doaj +1 more source
The effect of different types of hepatic injury on the estrogen and androgen receptor activity of liver [PDF]
, 1989 Mammalian liver contains receptors for both estrogens and androgens. Hepatic regeneration after partial hepatectomy in male rats is associated with a loss of certain male-specific hepatic characteristics.
Aten R. F. +24 more
core +1 more source