Does changing androgen receptor status during prostate cancer development impact upon cholesterol homeostasis? [PDF]
PLoS ONE, 2013 Recent evidence associates prostate cancer with high cholesterol levels, with cholesterol being an important raw material for cell-growth. Within the cell, cholesterol homeostasis is maintained by two master transcription factors: sterol-regulatory ...
James Robert Krycer, Andrew John Brown
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Pakistan Armed Forces Medical Journal, 2021 Objective: To determine the frequency of immunohistochemical expression of androgen receptor in triple negative breast carcinoma. Study Design: Cross sectional study.
Amna Ameer +3 more
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WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics [PDF]
, 2009 Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in non-adherent cultures.
A de la Taille +82 more
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Genetics Research, 2023 Objective. The purpose of our work was to explore the association of mutations in the androgen receptor gene and copy numbers of the androgen-receptor silk protein A complex with glutathione-S-transferases T1 and M1 in prostate cancer patients. Materials
Yan Zhang +4 more
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Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen. [PDF]
, 1993 Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone receptor superfamily. In this work the effect of androgens and antiandrogens on the expression of the human androgen receptor (hAR) in prostate and breast ...
Blasschke, Dorothea +4 more
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The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor [PDF]
, 2005 Prostate cancer is the second most common male malignancy in the western world an increasing incidence in an ageing population. Treatment of advanced prostate cancer relies on androgen deprivation.
Bakin RE +7 more
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Dissecting the roles of the androgen receptor in prostate cancer from molecular perspectives
Tumor Biology, 2017 Androgen receptor plays a pivotal role in prostate cancer progression, and androgen deprivation therapy to intercept androgen receptor signal pathway is an indispensable treatment for most advanced prostate cancer patients to delay cancer progression ...
Jieping Hu, Gongxian Wang, Ting Sun
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BMC Research Notes, 2018 Objectives Recent evidence suggests a role of androgen receptor expression as a prognostic and therapeutic biomarker in endometrial carcinoma, therefore in the present study we aimed to evaluate the frequency of androgen expression in different subtypes ...
Atif Ali Hashmi +7 more
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The CAG trinucleotide repeat length in the androgen receptor does not predict the early onset of prostate cancer [PDF]
, 2002 Objective To relate the repeat length of the androgen-receptor CAG trinucleotide to the age of onset of prostate cancer, stage and grade of disease. Patients and methods After obtaining ethical approval, 265 patients with locally confined or locally ...
Bartlett, J.M.S. +5 more
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Androgen Receptor Signaling in the Development of Castration-Resistant Prostate Cancer
Frontiers in Oncology, 2019 Most prostate cancers are androgen-sensitive malignancies whose growths depend on the transcriptional activity of the androgen receptor (AR). In the 1940s, Charles Huggins demonstrated that the surgical removal of testes in men can result in a dramatic ...
Qin Feng, Bin He, Bin He
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