Results 11 to 20 of about 2,496,118 (309)
Androgen receptor accelerates premature senescence of human dermal papilla cells in association with DNA damage. [PDF]
PLoS ONE, 2013 The dermal papilla, located in the hair follicle, expresses androgen receptor and plays an important role in hair growth. Androgen/Androgen receptor actions have been implicated in the pathogenesis of androgenetic alopecia, but the exact mechanism is not
Yi-Chien Yang +5 more
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Definitions, 2020 Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus.
semanticscholar +1 more source
Androgen receptor status is a prognostic marker in non-basal triple negative breast cancers and determines novel therapeutic options. [PDF]
PLoS ONE, 2014 Triple negative breast cancers are a heterogeneous group of tumors characterized by poor patient survival and lack of targeted therapeutics. Androgen receptor has been associated with triple negative breast cancer pathogenesis, but its role in the ...
Pierluigi Gasparini +13 more
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Androgen Receptor Signaling Pathway in Prostate Cancer: From Genetics to Clinical Applications
Cells, 2020 Around 80–90% of prostate cancer (PCa) cases are dependent on androgens at initial diagnosis; hence, androgen ablation therapy directed toward a reduction in serum androgens and the inhibition of androgen receptor (AR) is generally the first therapy ...
G. Aurilio +9 more
semanticscholar +1 more source
Filamin A cooperates with the androgen receptor in preventing skeletal muscle senescence
Cell Death Discovery, 2023 Aging induces a slow and progressive decrease in muscle mass and function, causing sarcopenia. Androgens control muscle trophism and exert important anabolic functions through the binding to the androgen receptor.
Marzia Di Donato +7 more
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Does changing androgen receptor status during prostate cancer development impact upon cholesterol homeostasis? [PDF]
PLoS ONE, 2013 Recent evidence associates prostate cancer with high cholesterol levels, with cholesterol being an important raw material for cell-growth. Within the cell, cholesterol homeostasis is maintained by two master transcription factors: sterol-regulatory ...
James Robert Krycer, Andrew John Brown
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Selective androgen receptor modulators: the future of androgen therapy?
Translational Andrology and Urology, 2020 Selective androgen receptor modulators (SARMs) are small molecule drugs that function as either androgen receptor (AR) agonists or antagonists. Variability in AR regulatory proteins in target tissues permits SARMs to selectively elicit anabolic benefits ...
Andrew R. Christiansen +3 more
semanticscholar +1 more source
Pakistan Armed Forces Medical Journal, 2021 Objective: To determine the frequency of immunohistochemical expression of androgen receptor in triple negative breast carcinoma. Study Design: Cross sectional study.
Amna Ameer +3 more
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Genetics Research, 2023 Objective. The purpose of our work was to explore the association of mutations in the androgen receptor gene and copy numbers of the androgen-receptor silk protein A complex with glutathione-S-transferases T1 and M1 in prostate cancer patients. Materials
Yan Zhang +4 more
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Dissecting the roles of the androgen receptor in prostate cancer from molecular perspectives
Tumor Biology, 2017 Androgen receptor plays a pivotal role in prostate cancer progression, and androgen deprivation therapy to intercept androgen receptor signal pathway is an indispensable treatment for most advanced prostate cancer patients to delay cancer progression ...
Jieping Hu, Gongxian Wang, Ting Sun
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