Results 11 to 20 of about 175,818 (256)

Androgen receptor mutations [PDF]

The Journal of Steroid Biochemistry and Molecular Biology, 1995
Male sexual differentiation and development proceed under direct control of androgens. Androgen action is mediated by the intracellular androgen receptor, which belongs to the superfamily of ligand-dependent transcription factors.
Boehmer, A.L.M. (Annemie), Brinkmann, A.O. (Albert), Brüggenwirth, H.T. (Hennie), Jenster, G.W. (Guido), Korput, J.A.G.M. (J. A G M) van der, Ris-Stalpers, C. (Carolyn), Trapman, J. (Jan)   +6 more
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Androgen receptor abnormalities [PDF]

The Journal of Steroid Biochemistry and Molecular Biology, 1991
The human androgen receptor is a member of the superfamily of steroid hormone receptors. Proper functioning of this protein is a prerequisite for normal male sexual differentiation and development.
Brinkmann, A.O. (Albert), Kuiper, G.G.J.M. (George), Mulder, E. (Eppo), Pinsky, L. (L.), Ris-Stalpers, C. (Carolyn), Romalo, G. (G.), Rooij, H.C.J. (Henri) van, Schweikert, H.U. (H.), Trapman, J. (Jan), Trifirò, G. (Gianluca)   +9 more
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Androgen regulation of the androgen receptor coregulators [PDF]

BMC Cancer, 2008
Abstract Background The critical role of the androgen receptor (AR) in the development of prostate cancer is well recognized. The transcriptional activity of AR is partly regulated by coregulatory proteins. It has been suggested that these coregulators could also be important in the progression of prostate cancer. The
Urbanucci, Alfonso, Waltering, Kati K, Suikki, Hanna E, Helenius, Merja A, Visakorpi, Tapio   +4 more
openaire   +5 more sources

Androgen Receptor Phosphorylation [PDF]

Endocrine Research, 1993
Phosphorylation of transcription factors plays an important role in regulation of gene expression. DNA-binding, transactivation activity, and subcellular trafficking of specific transcription factors have been shown to be regulated by phosphorylation/dephosphorylation.
Leen J. Blok, P.E. de Ruiter, Albert O. Brinkmann   +2 more
openaire   +4 more sources

The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor [PDF]

, 2005
Prostate cancer is the second most common male malignancy in the western world an increasing incidence in an ageing population. Treatment of advanced prostate cancer relies on androgen deprivation.
Bakin RE, Buchanan G, Chang C, Davies MA, Malik SN, Marcelli M, Taplin ME, Thakkar H   +7 more
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The impact of point mutations in the human androgen receptor : classification of mutations on the basis of transcriptional activity [PDF]

, 2011
Peer reviewedPublisher ...
A Godoy, A Haelens, A Monge, AN Vis, AO Brinkmann, B Cinar, B Gottlieb, B He, B He, B He, B Tiwary, BA Evans, C Cai, CA Berrevoets, CA Heinlein, Colin W. Hay, CT Kesler, CT Wu, D Ricketson, DJ Lamb, EB Askew, EP Gelmann, ER Hyytinen, G Buchanan, G Chen, G Verrijdt, GN Brooke, GP Reddy, H Faus, H Takahashi, HI Scher, HJ Dubbink, HT Bruggenwirth, I Ahrens-Fath, Iain J. McEwan, IJ McEwan, J Brodie, J Duff, J Edwards, J Geller, J Reid, J Tan, J Veldscholte, JA Locke, JD Wilson, Jean-Marc A. Lobaccaro, K Evaul, K Haapala, KB Cleutjens, KE Knudsen, KH Chang, KK Waltering, KM Lakshman, LJ Blok, M Fu, M Jagla, M Marcelli, M Sun, M Uemura, M Welsh, ME Baker, ME Taplin, ME Taplin, ME Taplin, MJ Linja, MM Centenera, MM Shen, N Mononen, OA O'Mahony, PA Watson, PE de Ruiter, Q Wang, R Betney, R Chenna, R Hu, R Schule, RJ Andersen, S Baron, S Haile, S Koochekpour, SM Dehm, SM Dehm, SM Powell, SS Dutt, SS Taneja, ST Page, TH Li, TM Tanner, W Li, Y Chen, Y Gluzman, Y Niu, Y Niu, Y Ogino, YD Li, Z Guo   +95 more
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The effect of different types of hepatic injury on the estrogen and androgen receptor activity of liver [PDF]

, 1989
Mammalian liver contains receptors for both estrogens and androgens. Hepatic regeneration after partial hepatectomy in male rats is associated with a loss of certain male-specific hepatic characteristics.
Aten R. F., Bannister P., Bardin C. W., Booth A. N., Cardon S. B., Chamness G. C., D. H. Van Thiel, D. Kahn, Eagon P. K., Eisenfeld A. J., Farrell G. C., Francavilla A., Francavilla A., Gustafsson J. A., H. Lai, Higgins E. M., L. Makowka, Lowry O. H., M. Kajani, P. K. Eagon, Q. Zeng, Starzl T. E., T. E. Starzl, Van DH Thiel, Van DH Thiel   +24 more
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WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics [PDF]

, 2009
Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in non-adherent cultures.
A de la Taille, A Glinka, A van Bokhoven, AA George, AP Verhagen, AS Waller, AT Collins, AT Collins, AT Collins, B Hoang, B Mao, BA Reynolds, C Lo Celso, C Wissmann, CC Carson 3rd, CI Truica, CL Hall, CL Hall, D Beier, D Bonnet, D Masiello, D Mizrak, DA Lawson, David M Prowse, DK Singla, DL Hudson, DL Hudson, DP Petrylak, DR Chesire, EM Hurt, G Dontu, G Gu, G Shaw, G Shaw, GD Richardson, GJ van Leenders, GL Shaw, GN Thalmann, H Clevers, H Li, H Zhu, HF English, Isabelle Bisson, IV Litvinov, IV Litvinov, J Miki, JA Schalken, JE Visvader, JM Adams, KD Bunting, KG Leong, L Adam, L Patrawala, L Patrawala, L Patrawala, L Ricci-Vitiani, L Vezzoni, L Xin, L Xin, LE Pascal, LG Wang, M Al-Hajj, M Locke, M Verras, MJ Linja, MS Chen, MS Wicha, N Uchida, PN Kelly, RI Bhatt, S Signoretti, S Weiss, S Zhou, SI Hwang, SK Singh, SM Janes, SV Shmelkov, T Hara, T Nikolova, T Reya, WJ Huss, Y Katoh, Y Lu   +82 more
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Androgen receptors in meningiomas [PDF]

Cancer, 1988
Meningiomas have been hypothesized as being hormonally sensitive on the basis of epidemiologic, clinical, and laboratory evidence. Eight meningiomas were assayed and found to have androgen-binding protein. Three tumors were subjected to in vitro growth studies in varying concentrations of dihydrotestosterone (DHT).
David W. Beck, Jeffrey J. Olson, Pao Min-Loh, John W. Macindoe   +3 more
openaire   +3 more sources

Unusual specificity of the androgen receptor in the human prostate tumor cell line LNCaP: High affinity for progestagenic and estrogenic steroids [PDF]

, 1990
LNCaP tumor cells, derived from a metastatic lesion of a human prostatic carcinoma, are androgen-sensitive in cell culture. Although increase in growth rate is observed with low doses of progestagens or estradiol, these cells contain exclusively androgen
Bolt-de Vries, J. (Joan), Mulder, E. (Eppo), Rooij, H.C.J. (Henri) van, Trapman, J. (Jan), Veldscholte, J. (Jos), Voorhorst-Ogink, M.M. (M.)   +5 more
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