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Androgen receptor mutations and androgen insensitivity
Molecular and Cellular Endocrinology, 2002The androgen receptor (AR) is a high affinity receptor protein encoded on the human X-chromosome that mediates the actions of androgens during development and in the adult. Defects in this receptor protein result in a wide range of abnormalities of male sexual development.
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Androgens and Androgen Receptor in Dermatology
2002In addition to male sexual development and maturation, androgens also mediate sebum secretion and hair growth. The effect of androgens is mainly through their binding to the androgen receptor (AR) which is a nuclear receptor superfamily member. These androgen-AR complexes then enhance their target genes’ expression by binding to response elements in ...
Uno Hideo +17 more
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The Androgen Receptor: An Overview
1994Publisher Summary This chapter provides an overview of the androgen receptor (AR). AR is a ligand-activated transcriptional regulatory protein that mediates androgen-induced male sexual development and function. The chapter presents a schematic diagram that highlights the major functional domains of human AR.
Elizabeth M. Wilson +3 more
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Nuclear receptors and disease: androgen receptor [PDF]
Essays in Biochemistry, 2004 The androgen receptor (AR) protein regulates transcription of certain genes. Usually this depends upon a central DNA-binding domain that permits the binding of androgen–AR complexes to regulatory DNA sequences near or in a target gene. The AR also has a C-terminal ligand-binding domain and an Nterminal transcription modulatory domain.
Jianhui Wu +8 more
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Androgen receptor polymorphism (CAG repeats) and androgenicity
Clinical Endocrinology, 2005SummaryObjective Polymorphism of the androgen receptor (AR) has been related to various pathophysiological conditions, such as osteoporosis and infertility. The objectives of this study were to evaluate the frequency of distribution in a normal Italian population and to assess CAG repeats (CAGr) in other conditions, such as hypoandrogenism ...
CANALE D +6 more
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2019
Androgens and the androgen receptor (AR) play crucial roles in the biology of normal and diseased prostate tissue, including prostate cancer (PCa). This dependence is evidenced by the use of androgen depletion therapy (ADT) as the primary treatment for locally advanced, metastatic, or relapsed PCa.
Aashi Chaturvedi, Scott M. Dehm
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Androgens and the androgen receptor (AR) play crucial roles in the biology of normal and diseased prostate tissue, including prostate cancer (PCa). This dependence is evidenced by the use of androgen depletion therapy (ADT) as the primary treatment for locally advanced, metastatic, or relapsed PCa.
Aashi Chaturvedi, Scott M. Dehm
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[12] Trafficking of the androgen receptor
1999Publisher Summary The androgen receptor (AR) belongs to the superfamily of nuclear receptors characterized by a common structure and mechanism of action. The AR is an androgen-dependent transcription factor composed of four domains: the amino-terminal transcription activation domain; the DNA-binding domain, which interacts with a specific DNA ...
Jean-Claude Nicolas +3 more
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Androgens and androgen receptor in prostate and ovarian malignancies
Frontiers in Bioscience, 2003The molecular and biochemical mechanisms contributing to the development and progression of both prostate and ovarian carcinogenesis are currently unknown. A better understanding of the cross-talk between endocrine, signal transduction and regulatory pathways in normal and neoplastic prostatic and ovarian tissues is necessary to elucidate malignant ...
Marianne D. Sadar, Katie Meehan
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Androgen Receptor and Estrogen Receptors
2002The androgen receptor (AR) and the estrogen receptors (ER) are members of the nuclear receptor (NR) family. These NRs are distinguished from the other transcription factors by their ability to control gene expression upon ligand binding (steroids, retinoids, thyroid hormone, vitamin D, fatty acids, and other small hydrophobic molecules). Their combined
H. M. Oosterkamp, R. Bernards
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Androgen dependency of the androgen receptor in rat epididymis
Biochemical and Biophysical Research Communications, 1975Abstract Binding of radioactive androgen to the 8S epididymal receptor is reduced to undetectable levels after 30 days of castration. Testosterone propionate(200 μg/day)administered starting immediately after castration and continued for 30 days prevented the disappearance of binding activity.
Ricardo S. Calandra +3 more
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