Results 21 to 30 of about 2,496,118 (309)

Androgen receptor expression in endometrial carcinoma and its correlation with clinicopathologic features

BMC Research Notes, 2018
Objectives Recent evidence suggests a role of androgen receptor expression as a prognostic and therapeutic biomarker in endometrial carcinoma, therefore in the present study we aimed to evaluate the frequency of androgen expression in different subtypes ...
Atif Ali Hashmi, Zubaida Fida Hussain, Amna Qadri, Muhammad Irfan, Sahar Ramzan, Naveen Faridi, Amir Khan, Muhammad Muzzammil Edhi   +7 more
doaj   +1 more source

Prognostic Value of Androgen Receptor Expression in Bladder Tumors [PDF]

Translational Research in Urology, 2023
Introduction: The present study was conducted with the aim of investigating the prognostic value of androgen receptor expression in bladder tumors.Methods: This study was conducted in the urology department of Imam Reza Hospital on male patients with ...
Salman Soltani, Sajjad Sadeghpour, Mahmood Reza Kalantari, Hamidreza Ghorbani, Majid Khadem Rezaiyan, Atena Aghaee, Mahmoud Tavakoli, Hamideh Heydari, Samira Assarian   +8 more
doaj   +1 more source

NON-GENOMIC ANDROGEN ACTION REGULATES PROLIFERATIVE/MIGRATORY SIGNALLING IN STROMAL CELLS.

Frontiers in Endocrinology, 2015
Prostate cancer is the major cause of cancer-related death among the male population of Western society, and androgen deprivation therapy represents the first line in prostate cancer treatment. However, although androgen receptor expression is maintained
Marzia eDi Donato, Pia eGiovannelli, Gustavo eCernera, Annalisa eDi Santi, Irene eMarino, Antonio eBilancio, Giovanni eGalasso, Ferdinando eAuricchio, Antimo eMigliaccio, Gabriella eCastoria   +9 more
doaj   +1 more source

Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells

Cancer Biology & Therapy, 2022
The αVβ6 integrin, an epithelial-specific cell surface receptor absent in normal prostate and expressed during prostate cancer (PrCa) progression, is a therapeutic target in many cancers.
Shiv Ram Krishn, Vaughn Garcia, Nicole M. Naranjo, Fabio Quaglia, Christopher D. Shields, Maisha A. Harris, Andrew V. Kossenkov, Qin Liu, Eva Corey, Dario C. Altieri, Lucia R. Languino   +10 more
doaj   +1 more source

Role of Androgen Receptor in Prostate Cancer: A Review

The World Journal of Men's Health, 2018
Androgen receptor (AR) is a steroid receptor transcriptional factor for testosterone and dihydrotestosterone consisting of four main domains, the N-terminal domain, DNA-binding domain, hinge region, and ligand-binding domain.
K. Fujita, N. Nonomura
semanticscholar   +1 more source

Second-Generation Antiandrogens: From Discovery to Standard of Care in Castration Resistant Prostate Cancer

Frontiers in Oncology, 2019
Prostate cancer is the most commonly diagnosed cancer affecting men in the United States. The prostate is a hormone-dependent gland in which androgen hormones testosterone and dihydrotestosterone bind to and activate the androgen receptor, initiating ...
Meghan A. Rice, Sanjay V. Malhotra, Sanjay V. Malhotra, Tanya Stoyanova   +3 more
doaj   +1 more source

Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance

Communications Biology, 2018
The androgen receptor is a major driver of prostate cancer and inhibition of its transcriptional activity using competitive antagonists, such as enzalutamide remains a frontline therapy for prostate cancer management.
J. Salami, Shanique Alabi, Ryan R Willard, N. Vitale, Jing Wang, Hanqing Dong, Meizhong Jin, D. McDonnell, A. Crew, T. Neklesa, C. Crews   +10 more
semanticscholar   +1 more source

Androgens and Androgen Receptor Actions on Bone Health and Disease: From Androgen Deficiency to Androgen Therapy

Cells, 2019
Androgens are not only essential for bone development but for the maintenance of bone mass. Therefore, conditions with androgen deficiency, such as male hypogonadism, androgen-insensitive syndromes, and prostate cancer with androgen deprivation therapy ...
Jia-Feng Chen, Pei-Wen Lin, Yi-Ru Tsai, Yi-Chien Yang, Hong-Yo Kang   +4 more
semanticscholar   +1 more source

Molecular cloning and characterization of a nuclear androgen receptor activated by 11-ketotestosterone

Reproductive Biology and Endocrinology, 2005
Although 11-ketotestosterone is a potent androgen and induces male secondary sex characteristics in many teleosts, androgen receptors with high binding affinity for 11-ketotestosterone or preferential activation by 11-ketotestosterone have not been ...
Karlsson Johnny, Larsson Anders, Hellqvist Anna, Grahn Birgitta, von Hofsten Jonas, Berg A Håkan, Olsson Per-Erik, Modig Carina, Borg Bertil, Thomas Peter   +9 more
doaj   +1 more source

In silico prediction of nuclear receptor binding to polychlorinated dibenzofurans and its implication on endocrine disruption in humans and wildlife

Current Research in Toxicology, 2021
Polychlorinated dibenzofurans (PCDFs) are known to cause endocrine disruption in humans and wildlife but the mechanisms underlying this disruption have not been adequately investigated.
Lukman K. Akinola, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi   +3 more
doaj   +1 more source