Results 21 to 30 of about 230,623 (311)

The androgen receptor: Functional structure and expression in transplanted human prostate tumors and prostate tumor cell lines [PDF]

, 1990
The growth of the majority of prostate tumors is androgen-dependent, for which the presence of a functional androgen receptor is a prerequisite. Tumor growth can be inhibited by blockade of androgen receptor action. However, this inhibition is transient.
Brinkmann, A.O. (Albert), Faber, P.W., Korput, J.A.G.M. (J. A G M) van der, Kuiper, G.G.J.M. (George), Mulder, E. (Eppo), Ris-Stalpers, C. (Carolyn), Romijn, J.C. (Johannes), Trapman, J. (Jan)   +7 more
core   +1 more source

Renal Subcapsular xenografing of human fetal external genital tissue - A new model for investigating urethral development. [PDF]

, 2017
In this paper, we introduce our novel renal subcapsular xenograft model for the study of human penile urethral and clitoral development. We grafted fifteen intact fetal penes and clitorides 8-11 weeks fetal age under the renal capsules of gonadectomized ...
Baskin, Laurence, Cao, Mei, Cunha, Gerald, Isaacson, Dylan, Shen, Joel, Sinclair, Adriane, Yue, Xuan   +6 more
core   +2 more sources

Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells

Cancer Biology & Therapy, 2022
The αVβ6 integrin, an epithelial-specific cell surface receptor absent in normal prostate and expressed during prostate cancer (PrCa) progression, is a therapeutic target in many cancers.
Shiv Ram Krishn, Vaughn Garcia, Nicole M. Naranjo, Fabio Quaglia, Christopher D. Shields, Maisha A. Harris, Andrew V. Kossenkov, Qin Liu, Eva Corey, Dario C. Altieri, Lucia R. Languino   +10 more
doaj   +1 more source

Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells [PDF]

, 2013
The development and growth of prostate cancer is dependent on androgens; thus, the identification of androgen-regulated genes in prostate cancer cells is vital for defining the mechanisms of prostate cancer development and progression and developing new ...
Brinkmann, Chen, Ciara O'Hanlon-Brown, Claessens, Cleutjens, Cook, Cunha, Dai, Devos, Feldman, Greg N Brooke, Gregory, Haelens, Haelens, Ham, Heinlein, Jonathan Waxman, Laki Buluwela, Lin, Lu, Luke, Lund, Massie, Massie, Ngan, Nird  , Rennie, Rowling, Shang, Shen, Silvia Ottaviani, Simak Ali, Song, Sreekumar, Verrijdt, Wang, Yu   +36 more
core   +1 more source

Unusual specificity of the androgen receptor in the human prostate tumor cell line LNCaP: High affinity for progestagenic and estrogenic steroids [PDF]

, 1990
LNCaP tumor cells, derived from a metastatic lesion of a human prostatic carcinoma, are androgen-sensitive in cell culture. Although increase in growth rate is observed with low doses of progestagens or estradiol, these cells contain exclusively androgen
Bolt-de Vries, J. (Joan), Mulder, E. (Eppo), Rooij, H.C.J. (Henri) van, Trapman, J. (Jan), Veldscholte, J. (Jos), Voorhorst-Ogink, M.M. (M.)   +5 more
core   +2 more sources

Mechanism of antiandrogen action: Conformational changes of the receptor [PDF]

, 1994
Androgen receptor mRNA was translated in vitro, and androgen- and antiandrogen-bound receptor complexes were studied using limited proteolytic digestion by trypsin.
Kuil, C.W. (Cor), Mulder, E. (Eppo)
core   +1 more source

Second-Generation Antiandrogens: From Discovery to Standard of Care in Castration Resistant Prostate Cancer

Frontiers in Oncology, 2019
Prostate cancer is the most commonly diagnosed cancer affecting men in the United States. The prostate is a hormone-dependent gland in which androgen hormones testosterone and dihydrotestosterone bind to and activate the androgen receptor, initiating ...
Meghan A. Rice, Sanjay V. Malhotra, Sanjay V. Malhotra, Tanya Stoyanova   +3 more
doaj   +1 more source

Effect of antiandrogen flutamide on measures of hepatic regeneration in rats [PDF]

, 1989
Male rat liver undergoes a process of demasculinization during hepatic regeneration following partial hepatectomy. The possibility that antiandrogens might potentiate this demasculinization process and in so doing augment the hepatic regenerative ...
A Francavilla, A Mode, A Schleusener, AE Pegg, AJ Syms, B Katchen, CL Mendenhall, CW Bardin, D Kahn, DM Cohen, E Bresnidk, E Mezey, E Mezey, E Mezey, EM Higgins, ER Lax, F Neumann, J Simard, J Terblanche, JA Gustafsson, JA Gustafsson, JA McGowan, JH Clark, JM Kissane, JP Blondeau, KE Crow, LE Porter, M Kayfman, M Sarff, MF Zuretti, OH Lowry, PK Eagon, PK Eagon, PK Eagon, R Neri, W Welshons, WJ King   +36 more
core   +1 more source

Molecular cloning and characterization of a nuclear androgen receptor activated by 11-ketotestosterone

Reproductive Biology and Endocrinology, 2005
Although 11-ketotestosterone is a potent androgen and induces male secondary sex characteristics in many teleosts, androgen receptors with high binding affinity for 11-ketotestosterone or preferential activation by 11-ketotestosterone have not been ...
Karlsson Johnny, Larsson Anders, Hellqvist Anna, Grahn Birgitta, von Hofsten Jonas, Berg A Håkan, Olsson Per-Erik, Modig Carina, Borg Bertil, Thomas Peter   +9 more
doaj   +1 more source

The Role of Androgen Receptor Signaling in Ovarian Cancer

Cells, 2019
Emerging evidence has suggested that androgen receptor signaling plays an important role in ovarian cancer outgrowth. Specifically, androgen receptor activation appears to be associated with increased risks of developing ovarian cancer and inducing tumor
Taichi Mizushima, Hiroshi Miyamoto
doaj   +1 more source