Results 21 to 30 of about 231,777 (344)

Prognostic Value of Androgen Receptor Expression in Bladder Tumors [PDF]

Translational Research in Urology, 2023
Introduction: The present study was conducted with the aim of investigating the prognostic value of androgen receptor expression in bladder tumors.Methods: This study was conducted in the urology department of Imam Reza Hospital on male patients with ...
Salman Soltani, Sajjad Sadeghpour, Mahmood Reza Kalantari, Hamidreza Ghorbani, Majid Khadem Rezaiyan, Atena Aghaee, Mahmoud Tavakoli, Hamideh Heydari, Samira Assarian   +8 more
doaj   +1 more source

The androgen receptor: Functional structure and expression in transplanted human prostate tumors and prostate tumor cell lines [PDF]

, 1990
The growth of the majority of prostate tumors is androgen-dependent, for which the presence of a functional androgen receptor is a prerequisite. Tumor growth can be inhibited by blockade of androgen receptor action. However, this inhibition is transient.
Brinkmann, A.O. (Albert), Faber, P.W., Korput, J.A.G.M. (J. A G M) van der, Kuiper, G.G.J.M. (George), Mulder, E. (Eppo), Ris-Stalpers, C. (Carolyn), Romijn, J.C. (Johannes), Trapman, J. (Jan)   +7 more
core   +1 more source

NON-GENOMIC ANDROGEN ACTION REGULATES PROLIFERATIVE/MIGRATORY SIGNALLING IN STROMAL CELLS.

Frontiers in Endocrinology, 2015
Prostate cancer is the major cause of cancer-related death among the male population of Western society, and androgen deprivation therapy represents the first line in prostate cancer treatment. However, although androgen receptor expression is maintained
Marzia eDi Donato, Pia eGiovannelli, Gustavo eCernera, Annalisa eDi Santi, Irene eMarino, Antonio eBilancio, Giovanni eGalasso, Ferdinando eAuricchio, Antimo eMigliaccio, Gabriella eCastoria   +9 more
doaj   +1 more source

Renal Subcapsular xenografing of human fetal external genital tissue - A new model for investigating urethral development. [PDF]

, 2017
In this paper, we introduce our novel renal subcapsular xenograft model for the study of human penile urethral and clitoral development. We grafted fifteen intact fetal penes and clitorides 8-11 weeks fetal age under the renal capsules of gonadectomized ...
Baskin, Laurence, Cao, Mei, Cunha, Gerald, Isaacson, Dylan, Shen, Joel, Sinclair, Adriane, Yue, Xuan   +6 more
core   +2 more sources

The effect of different types of hepatic injury on the estrogen and androgen receptor activity of liver [PDF]

, 1989
Mammalian liver contains receptors for both estrogens and androgens. Hepatic regeneration after partial hepatectomy in male rats is associated with a loss of certain male-specific hepatic characteristics.
Aten R. F., Bannister P., Bardin C. W., Booth A. N., Cardon S. B., Chamness G. C., D. H. Van Thiel, D. Kahn, Eagon P. K., Eisenfeld A. J., Farrell G. C., Francavilla A., Francavilla A., Gustafsson J. A., H. Lai, Higgins E. M., L. Makowka, Lowry O. H., M. Kajani, P. K. Eagon, Q. Zeng, Starzl T. E., T. E. Starzl, Van DH Thiel, Van DH Thiel   +24 more
core   +1 more source

Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells

Cancer Biology & Therapy, 2022
The αVβ6 integrin, an epithelial-specific cell surface receptor absent in normal prostate and expressed during prostate cancer (PrCa) progression, is a therapeutic target in many cancers.
Shiv Ram Krishn, Vaughn Garcia, Nicole M. Naranjo, Fabio Quaglia, Christopher D. Shields, Maisha A. Harris, Andrew V. Kossenkov, Qin Liu, Eva Corey, Dario C. Altieri, Lucia R. Languino   +10 more
doaj   +1 more source

Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells [PDF]

, 2013
The development and growth of prostate cancer is dependent on androgens; thus, the identification of androgen-regulated genes in prostate cancer cells is vital for defining the mechanisms of prostate cancer development and progression and developing new ...
Brinkmann, Chen, Ciara O'Hanlon-Brown, Claessens, Cleutjens, Cook, Cunha, Dai, Devos, Feldman, Greg N Brooke, Gregory, Haelens, Haelens, Ham, Heinlein, Jonathan Waxman, Laki Buluwela, Lin, Lu, Luke, Lund, Massie, Massie, Ngan, Nird  , Rennie, Rowling, Shang, Shen, Silvia Ottaviani, Simak Ali, Song, Sreekumar, Verrijdt, Wang, Yu   +36 more
core   +1 more source

Androgen receptor epigenetics.

Translational andrology and urology, 2013
The androgen receptor (AR) is a transcription factor that drives the differentiation of prostate epithelium by regulating the expression of several hundred genes. Conversely, AR also plays a central role in prostate cancer (PCa) development, and it continues to be active in tumors that relapse after castration (castration-resistant prostate cancer ...
Cai, Changmeng, Yuan, Xin, Balk, Steven P.   +2 more
openaire   +2 more sources

Androgen receptor phosphorylation at serine 515 by Cdk1 predicts biochemical relapse in prostate cancer patients [PDF]

, 2013
<br>Background:Prostate cancer cell growth is dependent upon androgen receptor (AR) activation, which is regulated by specific kinases. The aim of the current study is to establish if AR phosphorylation by Cdk1 or ERK1/2 is of prognostic ...
BV Kallakury, C E Adams, C Tannahill, D Gioeli, D Gioeli, G Fyffe, GG Kuiper, H Y Leung, H Zong, HY Wong, J Edwards, J Ferlay, J M Willder, JC Obenauer, JS Diallo, K Shigemura, KS McCarty, LA Ponguta, LJ Blok, M A Underwood, M Mistry, M Roach, M Seywright, MS Cookson, NG Anderson, P Chymkowitch, P G Horgan, P McCall, R Mukherjee, RE Bakin, RK Tyagi, S Chen, S Chen, S J Heng, SM Powell, T Kirkegaard, T Ohta, WC Bell, Y Wen, Z Fu, ZX Zhou   +40 more
core   +1 more source

Second-Generation Antiandrogens: From Discovery to Standard of Care in Castration Resistant Prostate Cancer

Frontiers in Oncology, 2019
Prostate cancer is the most commonly diagnosed cancer affecting men in the United States. The prostate is a hormone-dependent gland in which androgen hormones testosterone and dihydrotestosterone bind to and activate the androgen receptor, initiating ...
Meghan A. Rice, Sanjay V. Malhotra, Sanjay V. Malhotra, Tanya Stoyanova   +3 more
doaj   +1 more source