Results 21 to 30 of about 111,659 (312)
Frontiers in Oncology, 2019 Prostate cancer is the most commonly diagnosed cancer affecting men in the United States. The prostate is a hormone-dependent gland in which androgen hormones testosterone and dihydrotestosterone bind to and activate the androgen receptor, initiating ...
Meghan A. Rice +3 more
doaj +1 more source
The Role of Androgen Receptor Signaling in Ovarian Cancer
Cells, 2019 Emerging evidence has suggested that androgen receptor signaling plays an important role in ovarian cancer outgrowth. Specifically, androgen receptor activation appears to be associated with increased risks of developing ovarian cancer and inducing tumor
Taichi Mizushima, Hiroshi Miyamoto
doaj +1 more source
Reproductive Biology and Endocrinology, 2005 Although 11-ketotestosterone is a potent androgen and induces male secondary sex characteristics in many teleosts, androgen receptors with high binding affinity for 11-ketotestosterone or preferential activation by 11-ketotestosterone have not been ...
Karlsson Johnny +9 more
doaj +1 more source
Androgen receptor epigenetics.
Translational andrology and urology, 2013 The androgen receptor (AR) is a transcription factor that drives the differentiation of prostate epithelium by regulating the expression of several hundred genes. Conversely, AR also plays a central role in prostate cancer (PCa) development, and it continues to be active in tumors that relapse after castration (castration-resistant prostate cancer ...
Xin Yuan, Steven P. Balk, Changmeng Cai
openaire +3 more sources
Phosphorylation of androgen receptor isoforms [PDF]
Biochemical Journal, 2004 Phosphorylation of the human AR (androgen receptor) is directly correlated with the appearance of at least three AR isoforms on an SDS/polyacrylamide gel. However, it is still not clear to what extent phosphorylation is involved in the occurrence of isoforms, which sites are phosphorylated and what are the functions of these phosphosites.
Wong, H.Y. +11 more
openaire +7 more sources
Therapeutic potential of TRPM8 antagonists in prostate cancer
Scientific Reports, 2021 Transient receptor potential melastatin-8 (TRPM8) represents an emerging target in prostate cancer, although its mechanism of action remains unclear.
Marzia Di Donato +8 more
doaj +1 more source
BMC Research Notes, 2011 Background The androgen insensitivity syndrome may cause developmental failure of normal male external genitalia in individuals with 46,XY karyotype.
Guerra-Junior Gil +5 more
doaj +1 more source
PLoS ONE, 2012 Androgen receptor mediated signaling drives prostate cancer cell growth and survival. Mutations within the receptor occur infrequently in prostate cancer prior to hormonal therapy but become prevalent in incurable androgen independent and metastatic ...
Colin W Hay, Iain J McEwan
doaj +1 more source
Research Progress of Androgen/Androgen Receptor Signaling Pathway in Hepatocellular Carcinoma
Zhongliu Fangzhi Yanjiu, 2023 Hepatocellular carcinoma (HCC) is a kind of primary liver cancer with a high mortality rate. In China, the incidence ratio in males to females with HCC is 2:1–5:1.
WANG Ruihua +4 more
doaj +1 more source
The epigenetic function of androgen receptor in prostate cancer progression
Frontiers in Cell and Developmental Biology, 2023 Androgen and androgen deprivation (castration) therapies, including androgen receptor antagonists, are clinically used to treat patients with prostate cancer.
Takahiro Sawada +9 more
doaj +1 more source