Results 171 to 180 of about 72,539 (218)
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Androgens and androgen receptors in breast cancer
The Journal of Steroid Biochemistry and Molecular Biology, 2007Aromatase (CYP19) converts adrenal and ovarian androgens into estrogens, which supports the growth of estrogen-dependent breast cancers. Anti-aromatase agents are displacing antiestrogens as the first-line treatment for estrogen receptor positive breast cancers.
B, Nicolás Díaz-Chico +9 more
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Androgens, Antiandrogens and Androgen Receptor Abnormalities
European Urology, 1996Information on the molecular structure of the human androgen receptor has increased insight into the molecular mechanism of action of androgens and antiandrogens. It has also facilitated the study of molecular defects in the androgen receptor gene associated with prostate cancer.
C W, Kuil, A O, Brinkmann
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BioEssays, 2004
AbstractAndrogens (testosterone), acting via the androgen receptor (AR) a nuclear transcription factor, regulate male sexual development and body composition. In addition, AR expression plays an important role in the proliferation of human prostate cancer and confers a better prognosis in breast cancer. AR mRNA stability is central to the regulation of
Bu B, Yeap +2 more
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AbstractAndrogens (testosterone), acting via the androgen receptor (AR) a nuclear transcription factor, regulate male sexual development and body composition. In addition, AR expression plays an important role in the proliferation of human prostate cancer and confers a better prognosis in breast cancer. AR mRNA stability is central to the regulation of
Bu B, Yeap +2 more
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The androgen receptor in spermatogenesis
Cytogenetic and Genome Research, 2003Androgens are steroid hormones that are necessary for normal male phenotype expression, including the outward development of secondary sex characteristics as well as the initiation and maintenance of spermatogenesis. Many physiological actions of androgens are mediated by the androgen receptor (AR), a member of the nuclear receptor superfamily.
L L, Collins +6 more
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Androgen Receptor: An Overview
Critical Reviews in Eukaryotic Gene Expression, 1995The action of androgens in regulating development and growth is mediated by androgen receptor (AR). AR is a member of the steroid hormone receptor superfamily, a class of receptors that function through their ability to regulate the transcription of specific genes.
C, Chang +7 more
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Targeting the Androgen Receptor
Urologic Clinics of North America, 2012Androgen receptor (AR)-mediated signaling is critical to the growth and survival of prostate cancer. Although medical castration and antiandrogen therapy can decrease AR activity and lower PSA, castration resistance eventually develops. Recent work exploring the molecular structure and evolution of AR in response to hormonal therapies has revealed ...
Terence W, Friedlander, Charles J, Ryan
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Androgen receptor mutations and androgen insensitivity
Molecular and Cellular Endocrinology, 2002The androgen receptor (AR) is a high affinity receptor protein encoded on the human X-chromosome that mediates the actions of androgens during development and in the adult. Defects in this receptor protein result in a wide range of abnormalities of male sexual development.
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Androgen receptors and their biology
2001Publisher Summary The androgen receptor plays an important role in development and differentiated function in both health and disease. Advances in molecular biology have significantly impacted our knowledge of the role of this important member of the steroid receptor superfamily throughout the body. The chapter discusses that androgens freely diffuse
D J, Lamb, N L, Weigel, M, Marcelli
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The Androgen Receptor: An Overview
1994Publisher Summary This chapter provides an overview of the androgen receptor (AR). AR is a ligand-activated transcriptional regulatory protein that mediates androgen-induced male sexual development and function. The chapter presents a schematic diagram that highlights the major functional domains of human AR.
Z X, Zhou +3 more
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2019
Androgens and the androgen receptor (AR) play crucial roles in the biology of normal and diseased prostate tissue, including prostate cancer (PCa). This dependence is evidenced by the use of androgen depletion therapy (ADT) as the primary treatment for locally advanced, metastatic, or relapsed PCa.
Aashi P, Chaturvedi, Scott M, Dehm
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Androgens and the androgen receptor (AR) play crucial roles in the biology of normal and diseased prostate tissue, including prostate cancer (PCa). This dependence is evidenced by the use of androgen depletion therapy (ADT) as the primary treatment for locally advanced, metastatic, or relapsed PCa.
Aashi P, Chaturvedi, Scott M, Dehm
openaire +2 more sources