Results 51 to 60 of about 109,598 (309)

Targeting radiation‐induced upstream stimulatory factor‐1 by histone deacetylase inhibitors to reverse radioresistance in prostate cancer

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background Ionizing radiation (IR) is a standard modality for the management of solid tumors. Apart from its killing effects, IR can induce pro‐survival factors leading to radioresistance of cancer. Mechanistic understanding of radiation resistance is warranted to overcome the pro‐survival effects of IR.
Seema Gupta, Mansoor M. Ahmed
wiley   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Psychiatric morbidity among men using anabolic steroids

Depression and Anxiety, Volume 39, Issue 12, Page 805-812, December 2022., 2022
Abstract Objective The purpose of this study was to investigate the psychiatric morbidity among men with abuse of anabolic steroids. Methods The design is a retrospectively matched cohort study. Five hundred and fourty‐five males, who tested positive for anabolic steroids in Danish fitness centers during the period January 3, 2006 to March 1, 2018 ...
Josefine Windfeld‐Mathiasen, Thea Christoffersen, Niels August Willer Strand, Kim Dalhoff, Jon Trærup Andersen, Henrik Horwitz   +5 more
wiley   +1 more source

The multiple actions of testosterone in men: nature knows best

Asian Journal of Andrology, 2014
In male hormone replacement therapy Finkelstein et al. show that testosterone rather than synthetic "pure" androgens should be prescribed. Testosterone is converted to the superactive androgen dihydrotestosterone and to estradiol, and thus has actions ...
John W Funder
doaj   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Detection of 18‐methyl steroids: Case report on a forensic urine sample and corresponding dietary supplements

Drug Testing and Analysis, Volume 14, Issue 11-12, Page 1864-1870, November-December 2022., 2022
The detection of putative 18‐methyl‐19‐norandrosterone in a forensic urine sample has triggered a follow‐up investigation. Doping substances in the possession of the suspect were examined with regard to possible precursor steroids. 18‐Methyl‐19‐nortestosterone proved to be a suitable marker for reliable detection in doping analysis.
Detlef Thieme, Patricia Anielski, Sebastian Rzeppa, Clemens A. Wolf, Gerhard Wolber, Annekathrin M. Keiler   +5 more
wiley   +1 more source

Androgens added to immunosuppressive regimen in patients with aplastic anaemia. A retrospective study

Revista Médica del Hospital General de México, 2015
Background: Androgens have been used to treat bone marrow failure syndromes such as aplastic anaemia (AA) since the 1970s, and are currently used as adjuvants to other treatment regimens.
C.O. Ramos-Peñafiel, V.E. Ferrer-Argote, R. Trejo-Ayala, G. León-González, A. Santoyo-Sánchez, J. Collazo-Jaloma   +5 more
doaj   +1 more source

Androgens and bone [PDF]

Steroids, 2009
Testosterone is the major gonadal sex steroid produced by the testes in men. Testosterone is also produced in smaller amounts by the ovaries in women. The adrenal glands produce the weaker androgens dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione.
Sundeep Khosla, Bart L. Clarke
openaire   +2 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

The Roles of Androgen Receptors and Androgen-Binding Proteins in Nongenomic Androgen Actions [PDF]

Molecular Endocrinology, 2002
AbstractThe biological activity of testosterone and dihydrotestosterone is thought to occur predominantly through binding to the androgen receptor (AR), a member of the nuclear receptor superfamily that functions as a ligand-activated transcription factor.
Chawnshang Chang, Cynthia A. Heinlein
openaire   +3 more sources