Results 31 to 40 of about 2,751 (216)

Investigations on Phase I Metabolism of Anabolic Androgenic Steroids and Its Influenceability as Tool to Refine Steroid Detection and Evaluation [PDF]

, 2021
This thesis addresses the steroid metabolism and its role in the detection of steroids. The results were achieved by performing metabolic studies in combination with different analytical techniques. Three main outcomes were achieved.
Stoll, Anna
core   +1 more source

Metabolic fate of pregnene-based steroids in the lactonization pathway of multifunctional strain Penicillium lanosocoeruleum

Microbial Cell Factories, 2018
Background Metabolic activities of microorganisms to modify the chemical structures of organic compounds became an effective tool for the production of high-valued steroidal drugs or their precursors.
Alina Świzdor, Anna Panek, Paulina Ostrowska   +2 more
doaj   +1 more source

Androstane-3β,5α,6β,17β-tetrol trihydrate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
The title hydrated tetrol, C(19)H(32)O(4)·3H(2)O, was synthesized by stereoselective reduction of the compound 3β,5α,6β-trihy-droxy-androstan-17-one. All rings are fused trans. The organic mol-ecules are connected head-to-tail along the c axis via O-H⋯O hydrogen bonds. Layers of water mol-ecules in the ab plane inter-connect these chains.
Andrade, L. C. R., Almeida, M. J. B. M. de, Paixão, J. A., Carvalho, J. F. S., Melo, M. L. Sá e   +4 more
openaire   +3 more sources

Palaeoenvironmental reconstruction of Northern Spain during the last 8000 cal yr BP based on the biomarker content of the Roñanzas peat bog (Asturias) [PDF]

, 2010
We determined the lipid distributions (n-alkanes, n-methyl ketones, n-alkanoic acids, 5-n-alkyl resorcinols and sterols) and total organic carbon (TOC) content in a 2.0 m deep Sp/wgmim-dominated ombrotrophic peat bog in Northern Spain.
Torres Pérez-Hidalgo, Trinidad José
core   +2 more sources

Clinical Relevance of the Constitutive Androstane Receptor [PDF]

Drug Metabolism and Disposition, 2022
Constitutive androstane receptor (CAR) (NR1I3), a xenobiotic receptor, has long been considered a master mediator of drug disposition and detoxification. Accumulating evidence indicates that CAR also participates in various physiologic and pathophysiological pathways regulating the homeostasis of glucose, lipid, and bile acids, and contributing to cell
Sydney, Stern, Ritika, Kurian, Hongbing, Wang   +2 more
openaire   +2 more sources

Nontargeted evaluation of the fate of steroids during wastewater treatment by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry [PDF]

, 2016
Emerging organic contaminants in wastewater are usually analyzed by targeted approaches, and especially estrogens have been the focus of environmental research due to their high hormonal activity. The selection of specific target compounds means, however,
Kopperi, Matias, Parshintsev, Jevgeni, Riekkola, Marja-Liisa, Ruiz-Jimenez, Jose   +3 more
core   +1 more source

Identification of neuroactive steroids and their precursors and metabolites in adult male rat brain [PDF]

, 2005
Steroids in the brain arise both from local synthesis and from peripheral sources and have a variety of effects on neuronal function. However, there is little direct chemical evidence for the range of steroids present in brain or of the pathways for ...
Corol, DI, Ebner, MJ, Fry, JP, Havlikova, H, Honour, JW   +4 more
core   +1 more source

Challenges Predicting Ligand-Receptor Interactions of Promiscuous Proteins: The Nuclear Receptor PXR [PDF]

, 2009
Transcriptional regulation of some genes involved in xenobiotic detoxification and apoptosis is performed via the human pregnane X receptor (PXR) which in turn is activated by structurally diverse agonists including steroid hormones.
A Bender, A Biswas, A Khandelwal, AE Klon, AK Dunker, AK Ghose, B Blumberg, BL Urquhart, CR Yates, CY Ung, D Gupta, D Rogers, D Schuster, DG Teotico, DG Teotico, Erica J. Reschly, G Bertilsson, G Jones, IV Tetko, IV Tetko, J Feng, J Zhou, James M. Briggs, JE Chrencik, JT Metz, K Azzaoui, K Bachmann, K Yasuda, M Hassan, M Suarez, MA Lill, MA Lill, MA Lill, Manisha Iyer, Markus A. Lill, Matthew D. Krasowski, Matthew R. Redinbo, MD Krasowski, MD Krasowski, MN Jacobs, Nidhi, P Prathipati, RD Cramer, RE Watkins, RE Watkins, RE Watkins, S Ekins, S Ekins, S Ekins, S Ekins, S Ekins, S Ekins, S Kortagere, S Kortagere, S Kortagere, S Mani, S Verma, SA Kliewer, Sandhya Kortagere, Sean Ekins, W Mnif, WL DeLano, Y Xue, Y Xue, YD Gao   +64 more
core   +7 more sources

Circulating steroid levels as correlates of adipose tissue phenotype in premenopausal women [PDF]

, 2018
Background: Obesity-related alterations in the circulating steroid hormone profile remain equivocal in women. Our objective was to identify circulating steroid levels that relate to increased adiposity and altered adipose phenotype in premenopausal ...
Adamski, Jerzy, Carreau, Anne-Marie, Cianflone, Katherine M., Côté, Julie Anne, Daris, Marleen, Laforest, Sofia, Marchand, Geneviève B., Prehn, Cornelia, Tchernof, André   +8 more
core   +1 more source

Influence of Indomethacin on Steroid Metabolism: Endocrine Disruption and Confounding Effects in Urinary Steroid Profiling of Anti-Doping Analyses [PDF]

, 2020
Anabolic androgenic steroids (AAS) are prohibited as doping substances in sports by the World Anti-Doping Agency. Concentrations and concentration ratios of endogenous AAS (steroid profile markers) in urine samples collected from athletes are used to ...
Botrè, Francesco, De Gregorio, Giuseppina, de la Torre, Xavier, Iannone, Michele, Molaioni, Francesco, Parr, Maria Kristina, Stoll, Anna   +6 more
core   +1 more source