Results 101 to 110 of about 798 (134)

Androstene-3,5-dienes as ER-β selective SERMs

Bioorganic & Medicinal Chemistry Letters, 2007
A series of androstene-3,5-diene derivatives were prepared. Despite lacking the C-3 hydroxyl previously believed necessary for ER activity, some of the analogs retained surprising affinity for ER-beta. For example, diene 4 retained excellent selectivity and potency as an ER-beta agonist and was more selective for ER-beta over the androgen receptor (AR).
Timothy A, Blizzard, Candido, Gude, Jerry D, Morgan, Wanda, Chan, Elizabeth T, Birzin, Marina, Mojena, Consuelo, Tudela, Fang, Chen, Kristin, Knecht, Qin, Su, Bryan, Kraker, Ralph T, Mosley, Mark A, Holmes, Susan P, Rohrer, Milton L, Hammond   +14 more
openaire   +2 more sources

The mechanism of the synthesis of 16-androstenes in human testicular homogenates

Journal of Steroid Biochemistry, 1989
The biochemical pathway leading to the 16-unsaturated C19 steroids--known as sex pheromone (precursors) in pig and man--is still a matter of dispute. In the 16-ene-synthetase process, via which 5,16-androstadien-3 beta-ol (ADL) or 4,16-androstadien-3-one (ADN) are biosynthesized from pregnenolone (P5) or progesterone (P4), a number of 2 or even 3 step ...
J J, Weusten, G, Legemaat, M P, van der Wouw, A G, Smals, P W, Kloppenborg, T, Benraad   +5 more
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Immune up-regulation and tumor apoptosis by androstene steroids

Steroids, 2002
beta Androstenes steroid up-regulates immunity to increase resistance against lethal infection and lethal radiation, and mediates a rapid recovery of hematopoietic precursor cells after radiation injury. beta Androstenetriol increases the levels of the TH(1) cytokines, IL-2, IL-3, IFN gamma and counteracts hydrocortisone mediated immune suppression. In
openaire   +2 more sources

Isomerization of 5-androsten-3,17-dione by hepatic tissue

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1969
Abstract The properties of the system in the soluble fraction of rat liver which catalyzes the conversion of 5-androsten-3,17-dione to the corresponding Δ 4 -3-ketone have been studied. Two components are required: a protein and a dialyzable organic molecule.
openaire   +2 more sources

Comparative analysis of the effect of gestagens, antiestrogencytostatics, and androstenes on the viability of tumor and normal cells

Pharmaceutical Chemistry Journal, 2007
A V Semeikin, V V Banin, G S Grinenko
exaly  

Separation of some 16-androstenes on hydroxyyalkoxypropyl-Sephadex (LipidexTM)

Journal of Chromatography A, 1975
D B Gower, D B Gower
exaly  

Über Δ‐Androsten‐dion‐(3.17)

Berichte der deutschen chemischen Gesellschaft (A and B Series), 1936
Adolf Butenandt, Heinz Dannenberg
openaire   +1 more source

The hydroxylation of Δ5-androstenes by Cephalosporium aphidicola

Phytochemistry, 1998
James Hanson
exaly  

Simultaneous quantification of five odorous steroids (16-androstenes) in the axillary hair of men

The Journal of Steroid Biochemistry, 1988
D B Gower, D B Gower
exaly  

17-Aminoacylamido-5-androsten-3.beta.-ols

Journal of Medicinal Chemistry, 1968
G, Fluoret, W, Cole
openaire   +2 more sources