Results 81 to 90 of about 798 (134)

Abiraterone vs Enzalutamide Among US Veterans With Metastatic Hormone-Sensitive Prostate Cancer.

JAMA Netw Open
Leuva H, Zhou M, Teply BA, Park YA, Luhrs C, Mundi PS, Bates SE, Faiena I, Fojo T, Schoen MW.   +9 more
europepmc   +1 more source

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A new approach to Δ16-androstenes

Tetrahedron Letters, 1962
L. Caglioti, M. Magi
exaly   +2 more sources

2‐(Hydroxymethyl)androstene Derivatives [PDF]

Liebigs Annalen der Chemie, 1987
Abstract3‐Hydroxy‐2‐hydroxymethyl‐ (2 and 3) and 3‐hydroxymethyl‐3‐oxoandrostenes 4 were prepared from 2‐hydroxymethylene derivatives 1. The configurations of the chiral centers were determined on the basis of chiroptical, spectroscopical, and X‐ray analytical data. Furthermore, elimination reaction products (5, 6) were identified.
Vincze Irén, Somlai Csaba, Schneider Gyula, Dombi György, Kálmán Alajos   +4 more
openaire   +1 more source

A synthetic androstene derivative and a natural androstene metabolite inhibit relapsing–remitting EAE

Journal of Neuroimmunology, 2002
Experimental allergic encephalomyelitis (EAE), a Th1 polarized demyelinating disease of the central nervous system (CNS), shares many pathological and clinical similarities with multiple sclerosis (MS), and thus represents an attractive animal model for this disease. The goal of this study was to evaluate the suppressive effects of fluasterone (HE2500),
Offner, Halina, Zamora, Alex, Drought, Heather, Matejuk, Agata, Auci, Dominick, Morgan, Elizabeth, Vandenbark, Arthur, Reading, Christopher   +7 more
openaire   +2 more sources

Biological Evaluation of Androstene Derivatives

Archiv der Pharmazie, 2012
AbstractThe effect of several new dihydroepiandrosterone ester derivatives A2–A6 was demonstrated using female cycling mice, which were synchronized for estrus with luteinizing hormone‐releasing hormone (LHRH) and injected with the steroids. The binding to the progesterone receptor (PR), was obtained from the cytosol of uteri from adult estrogen‐primed
Mariana, Garrido, Eugene, Bratoeff, Mario, García-Lorenzana, Yvonne, Heuze, Juan, Soriano, Norma, Valencia, Francisco, Cortes, Marisa, Cabeza   +7 more
openaire   +2 more sources

Hydroalkoxycarbonylation of androstene derivatives

Tetrahedron Letters, 1992
Abstract Various esters are conveniently prepared by direct hydroesterification of the corresponding androstene derivatives with alcohols and carbon monoxide catalyzed by a palladium-phosphine catalyst with high stereoselectivity.
Szilárd Törös, Bálint Heil, György Gálik, Zoltán Tuba   +3 more
openaire   +1 more source

A Closer Look at the Isomerization of 5-Androstene-3,17-Dione to 4-Androstene-3,17-Dione in Ketosteroid Isomerase

Journal of Computational Biophysics and Chemistry, 2022
We report a comprehensive investigation of the 5-androstene-3,17-dione to 4-androstene-3,17-dione isomerization in Ketosteroid Isomerase, gas phase and aqueous solution, applying as tools the Unified Reaction Valley Approach (URVA) and the Local Vibrational Mode Analysis.
Marek Freindorf, Yunwen Tao, Elfi Kraka
openaire   +1 more source

THE BIOSYNTHESIS AND OCCURRENCE OF 16-ANDROSTENES IN MAN

1981
exaly   +2 more sources

An improved radioimmunoassay for 4-androstene-3,17-dione

Steroids, 1977
A radioimmunoassay using an antiserum produced against 6beta-hydroxy-4-androstene-3,17-dione-6-succinyl-BSA conjugate is described which permits the rapid determination of 4-androstene-3,17-dione in multiple serum samples that are purified by column chromatography on neutral alumina. Steroids which reacted significantly with the antiserum were found to
L N, Parker, P K, Grover, W D, Odell
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The metabolism of 16-androstenes in boar salivary glands

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1972
Abstract The metabolism of 5α-[5α- 3 H]androst-16-en-3-one and [7α- 3 H]androsta-4, 16-dien-3-one by minces of boar submaxillary and parotid glands has been studied. Both ketones were reduced to mixtures of 5α-androst-16-en-3α- and -3β-ols by submaxillary gland tissue and to the 3α-alcohol by parotid gland tissue.
T, Katkov, W D, Booth, D B, Gower
openaire   +2 more sources