Results 1 to 10 of about 792,967 (291)

VEGF dose controls the coupling of angiogenesis and osteogenesis in engineered bone

npj Regenerative Medicine, 2023
Vascular endothelial growth factor-A (VEGF) physiologically regulates both angiogenesis and osteogenesis, but its application in bone tissue engineering led to contradictory outcomes.
Andrea Grosso, Alexander Lunger, Maximilian G. Burger, Priscilla S. Briquez, Francesca Mai, Jeffrey A. Hubbell, Dirk J. Schaefer, Andrea Banfi, Nunzia Di Maggio   +8 more
doaj   +1 more source

The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer [PDF]

, 2005
<b>OBJECTIVE</b>: To test the hypothesis that angiogenesis in prostate cancer is associated with tumour invasion and metastasis, and that this is mediated through increased cyclooxygenase-2 (COX-2) expression.
Bartlett, J.M.S., Edwards, J., Mukherjee, R., Underwood, M.A.   +3 more
core   +1 more source

Isolation and separation of murine tumor-associated macrophages (TAMs) subpopulations from orthotopic 4T1 breast tumors

STAR Protocols, 2021
Summary: Tumor-associated macrophages (TAMs) are highly heterogenous regarding their intratumoral localization, surface marker expression, and molecular properties.
Pawel Bieniasz-Krzywiec, Rosa Martín-Pérez, Carla Riera-Domingo, Massimiliano Mazzone   +3 more
doaj   +1 more source

High mitogenic stimulation arrests angiogenesis

Nature Communications, 2019
High mitogenic stimuli have been suggested to promote endothelial cell proliferation and sprouting during angiogenesis. Here Pontes-Quero et al., by interfering with levels of VEGF and Notch signalling in single endothelial cells in vivo, find that high ...
Samuel Pontes-Quero, Macarena Fernández-Chacón, Wen Luo, Federica Francesca Lunella, Verónica Casquero-Garcia, Irene Garcia-Gonzalez, Ana Hermoso, Susana F. Rocha, Mayank Bansal, Rui Benedito   +9 more
doaj   +1 more source

Publisher Correction: High mitogenic stimulation arrests angiogenesis

Nature Communications, 2019
The original version of this Article contained errors in Fig. 8. In panel a, the labels ‘VEGF’, ‘Notch’, ‘p21’, and ‘P-ERK’ were inadvertently omitted. This has been corrected in the PDF and HTML versions of the Article.
Samuel Pontes-Quero, Macarena Fernández-Chacón, Wen Luo, Federica Francesca Lunella, Verónica Casquero-Garcia, Irene Garcia-Gonzalez, Ana Hermoso, Susana F. Rocha, Mayank Bansal, Rui Benedito   +9 more
doaj   +1 more source

How Endothelial Cells Adapt Their Metabolism to Form Vessels in Tumors

Frontiers in Immunology, 2017
Endothelial cells (ECs) line blood vessels, i.e., vital conduits for oxygen and nutrient delivery to distant tissues. While mostly present as quiescent “phalanx” cells throughout adult life, ECs can rapidly switch to a migratory “tip” cell and a ...
Annalisa Zecchin, Annalisa Zecchin, Joanna Kalucka, Joanna Kalucka, Charlotte Dubois, Charlotte Dubois, Peter Carmeliet, Peter Carmeliet   +7 more
doaj   +1 more source

Angiotensin II and VEGF are Involved in Angiogenesis Induced by Short-Term Exercise Training [PDF]

, 2001
Results from our laboratory have suggested a pathway involving angiotensin II type 1 (AT1) receptors and vascular endothelial growth factor (VEGF) in angiogenesis induced by electrical stimulation.
Amaral, Sandra L., Greene, Andrew S., Papanek, Paula   +2 more
core   +2 more sources

Glycolytic regulation of cell rearrangement in angiogenesis

Nature Communications, 2016
Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing ...
Bert Cruys, Brian W. Wong, Anna Kuchnio, Dries Verdegem, Anna Rita Cantelmo, Lena-Christin Conradi, Saar Vandekeere, Ann Bouché, Ivo Cornelissen, Stefan Vinckier, Roeland M. H. Merks, Elisabetta Dejana, Holger Gerhardt, Mieke Dewerchin, Katie Bentley, Peter Carmeliet   +15 more
doaj   +1 more source

Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. [PDF]

, 2014
To enable new blood vessel growth, endothelial cells (ECs) express neuropilin 1 (NRP1), and NRP1 associates with the receptor tyrosine kinase VEGFR2 after binding the vascular endothelial growth factor A (VEGF) to enhance arteriogenesis.
Alessandro Fantin, Anastasia Lampropoulou, Anissa Chikh, Anselmi, Ballmer-Hofer, Baruzzi, Birukova, Buchdunger, Campochiaro, Carmeliet, Casanovas, Chen, Chen, Chislock, Cho, Choi, Christiana Ruhrberg, Clark, Claudio Raimondi, Colicelli, Connor, Cui, Cujec, Dejana, Druker, Fantin, Fantin, Fantin, Fantin, Foxton, Fukasawa, Gerhardt, Gerhardt, Herzog, Kawamura, Kawasaki, Kim, Kitsukawa, Koch, Lanahan, Lanahan, Laura Denti, Lewis, Lewis, Mamluk, Murga, Nishijima, Pan, Pan, Parsons, Pasapera, Phng, Raimondi, Ren, Robinson, Roig, Rosenfeld, Ruhrberg, Ruhrberg, Saint-Geniez, Salikhova, Shimizu, Shojaei, Smith, Soker, Sottile, Stenzel, Tvorogov, Uemura, Valdembri, Wang, Welti, Yaqoob, Zaidel-Bar, Zhuang   +74 more
core   +4 more sources

Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis [PDF]

, 2016
This is the preprint version of our manuscript, corresponding to the article that has been 
published in final form at FOOD CHEMISTRY with DOI: 10.1016/j.foodchem.2016.10.111The health benefits of olive oil are attributed to their bioactive compounds ...
García-Vilas, Javier A., Medina, Miguel Ángel, Quesada, Ana R.   +2 more
core   +1 more source