Results 1 to 10 of about 991,798 (411)

Pathological angiogenesis: mechanisms and therapeutic strategies

Angiogenesis, 2023
In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-existing ones, is an essential process for growth and development. Different mechanisms such as vasculogenesis, sprouting, intussusceptive, and coalescent angiogenesis,
A. Dudley, A. Griffioen
semanticscholar   +1 more source

A Whole‐Course‐Repair System Based on Neurogenesis‐Angiogenesis Crosstalk and Macrophage Reprogramming Promotes Diabetic Wound Healing

Advances in Materials, 2023
Diabetic wound (DW) therapy is currently a big challenge in medicine and strategies to enhance neurogenesis and angiogenesis have appeared to be a promising direction.
Y. Xiong, Ze Lin, Pengzhen Bu, Tao Yu, Y. Endo, Wu Zhou, Yun Sun, Faqi Cao, Guandong Dai, Yiqiang Hu, Li Lu, Lang Chen, Peng Cheng, Kangkang Zha, M. Shahbazi, Q. Feng, B. Mi, Guohui Liu   +17 more
semanticscholar   +1 more source

Differential roles of eNOS in late effects of VEGF-A on hyperpermeability in different types of endothelial cells

Scientific Reports, 2023
Vascular endothelial growth factor (VEGF)-A induces endothelial hyperpermeability, but the molecular pathways remain incompletely understood. Endothelial nitric oxide synthase (eNOS) regulates acute effects of VEGF-A on permeability of endothelial cells (
Esmeralda K. Bosma, Shahan Darwesh, Yasmin I. Habani, Maxime Cammeraat, Paola Serrano Martinez, Mathilda E. van Breest Smallenburg, Jia Y. Zheng, Ilse M. C. Vogels, Cornelis J. F. van Noorden, Reinier O. Schlingemann, Ingeborg Klaassen   +10 more
doaj   +1 more source

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.

New England Journal of Medicine, 2020
BACKGROUND Progressive respiratory failure is the primary cause of death in the coronavirus disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of the disease, relatively little is known about the associated morphologic ...
M. Ackermann, S. Verleden, M. Kuehnel, A. Haverich, T. Welte, F. Laenger, A. Vanstapel, C. Werlein, Helge Stark, A. Tzankov, William Li, V. Li, S. Mentzer, D. Jonigk   +13 more
semanticscholar   +1 more source

Tumor angiogenesis

Advances in Cancer Research, 2020
The hypothesis that tumors are angiogenesis dependent has, in the past decade, generated new investigations designed to elucidate the mechanism of angiogenesis itself. Many laboratories are now engaged in this pursuit. Some are studying angiogenesis that
Farah Fatmawati, Whendy Wijaksono
semanticscholar   +1 more source

Receptor interacting protein 3 kinase, not 1 kinase, through MLKL-mediated necroptosis is involved in UVA-induced corneal endothelium cell death

Cell Death Discovery, 2021
Ultraviolet (UV) is one of the most energetic radiations in the solar spectrum that can result in various tissue injury disorders. Previous studies demonstrated that UVA, which represents 95% of incident photovoltaic radiation, induces corneal ...
Zhen Yu, Nikolaos E. Efstathiou, Victor S. M. C. Correa, Xiaohong Chen, Kenji Ishihara, Yasuhiro Iesato, Toshio Narimatsu, Dimitrios Ntentakis, Yanyun Chen, Demetrios G. Vavvas   +9 more
doaj   +1 more source

New Insight on 2D In Vitro Angiogenesis Models: All That Stretches Is Not a Tube

Cells, 2022
A Matrigel-based tube formation assay is a simple and widely accepted 2D angiogenesis model in vitro. Extracellular matrix (EM) proteins and growth factors (GFs) from MatrigelTM exclusively trigger endothelial cell (EC) tubular network (ETN) formation ...
Irina Beloglazova, Ekaterina Zubkova, Konstantin Dergilev, Yulia Goltseva, Yelena Parfyonova   +4 more
doaj   +1 more source

p53 expression as a prognostic marker in hepatocellular carcinoma [PDF]

Archives of Biological Sciences, 2014
Hepatocellular carcinoma (HCC) is one of the most frequent cancers worldwide with a high mortality. Immunohistochemical overexpression of the p53 protein was correlated with a poor prognosis in various human malignancies, including HCC.
Cioca Andreea, Cimpean Maria Anca, Kundnani Nilima Rajpal, Ceausu Raluca, Suciu Cristian, Raica Marius   +5 more
doaj   +1 more source

Local photoreceptor cell death differences in the murine model of retinal detachment

Scientific Reports, 2021
To investigate local cell death differences in the attached and detached retina at different regions in a murine experimental retinal detachment model. Subretinal injection of sodium hyaluronate was performed in eight-week-old C57BL/6J mice.
Daniel E. Maidana, Lucia Gonzalez-Buendia, Joan W. Miller, Demetrios G. Vavvas   +3 more
doaj   +1 more source

Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth

Journal of Experimental & Clinical Cancer Research, 2022
Background Mitochondrial fusion and fission proteins have been nominated as druggable targets in cancer. Whether their inhibition is efficacious in triple negative breast cancer (TNBC) that almost invariably develops chemoresistance is unknown.
Margherita Zamberlan, Amandine Boeckx, Florian Muller, Federica Vinelli, Olivier Ek, Caterina Vianello, Emeline Coart, Keitaro Shibata, Aurélie Christian, Francesca Grespi, Marta Giacomello, Ingrid Struman, Luca Scorrano, Stéphanie Herkenne   +13 more
doaj   +1 more source