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Mesoscopic and continuum modelling of angiogenesis [PDF]

Journal of Mathematical Biology February 2015, Volume 70, Issue 3, pp 485-532, 2014
Angiogenesis is the formation of new blood vessels from pre-existing ones in response to chemical signals secreted by, for example, a wound or a tumour. In this paper, we propose a mesoscopic lattice-based model of angiogenesis, in which processes that include proliferation and cell movement are considered as stochastic events.
Alarcon, Tomas, Byrne, Helen M., Guerrero, Pilar, Maini, Philip K., Spill, Fabian   +4 more
arxiv   +3 more sources

Spatio-temporal Models of Lymphangiogenesis in Wound Healing [PDF]

arXiv, 2016
Several studies suggest that one possible cause of impaired wound healing is failed or insufficient lymphangiogenesis, that is the formation of new lymphatic capillaries. Although many mathematical models have been developed to describe the formation of blood capillaries (angiogenesis), very few have been proposed for the regeneration of the lymphatic ...
A Bianchi, A Castiglioni, A Christiansen, A Friedman, A Gosiewska, A Louveau, A Mantovani, A Saaristo, A Stéphanou, AB Sutton, AI Papaioannou, AJ Macdonald, AJ Singer, Arianna Bianchi, AV Benest, AW Taylor, AY Sheikh, B Greenwood, B Kaminska, B Whitehurst, BE Farrell, BM Berg van den, C Cao, C Heppell, C Norrmen, CA Cobbold, CH Cho, CL Helm, CT Ambrose, D Ludwig, DJ Grainger, DR Brown, E Hormbrey, E Mendoza, EK Rofstad, ETT Withington, F Krombach, F Mac Gabhann, G Crescenzo De, G Müller, G Oliver, GF Pierce, GJ Goodhill, H Brem, H Kaur, H Staden von, HA Levine, HM Byrne, HM Byrne, HV Waugh, I Barkefors, I Choi, I Nunes, I Zachary, J Asai, J Goldman, J Posnett, JA Flegg, JC Zhuang, JD Shields, JF Douglas, JJL Velázquez, JJL Velázquez, JM Rutkowski, JM Rutkowski, Jonathan A. Sherratt, JP Yang, K Maruyama, K Weber-Matthiesen, KC Boardman, KE Murphy, Kevin J. Painter, KN Margaris, L Edelstein, L Yang, LM Wakefield, M Fischer, M Hyytiäinen, M Lohela, M Oi, M Scianna, M Shi, MAJ Chaplain, ME Fleury, ME Swift, MH Witte, MTGT May, N Khalil, N Khalil, N Li Jeon, NP Reddy, NV Mantzaris, P Drew, P Galie, PN Bernatchez, R Boulton, R Huggenberger, RC Ji, RC Schugart, RH Adams, RS Sweat, RT Tranquillo, S Kiriakidis, S Lee, S Monstrey, S Podgrabinska, S Zimny, SJ Lunt, SM Wahl, T Miura, T Roose, T Tammela, TG Simonsen, TL Haas, VPKH Nguyen, WJ Jeffcoate, Y Cao, Y Zheng   +117 more
arxiv   +3 more sources

A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis. [PDF]

, 2013
Fibroblast growth factor-1 (FGF1) and FGF2 play a critical role in angiogenesis, a formation of new blood vessels from existing blood vessels. Integrins are critically involved in FGF signaling through crosstalk. We previously reported that FGF1 directly
Fujita, Masaaki, Hamada, Yoshinosuke, Kaneda, Teruya, Kawaguchi, Naomasa, Matsuura, Nariaki, Mori, Seiji, Nishikawa, Kyoko, Saegusa, Jun, Takada, Yoko K, Takada, Yoshikazu, Tran, Vu, Zhao, Min   +11 more
core   +12 more sources

Differential roles of eNOS in late effects of VEGF-A on hyperpermeability in different types of endothelial cells

Scientific Reports, 2023
Vascular endothelial growth factor (VEGF)-A induces endothelial hyperpermeability, but the molecular pathways remain incompletely understood. Endothelial nitric oxide synthase (eNOS) regulates acute effects of VEGF-A on permeability of endothelial cells (
Esmeralda K. Bosma, Shahan Darwesh, Yasmin I. Habani, Maxime Cammeraat, Paola Serrano Martinez, Mathilda E. van Breest Smallenburg, Jia Y. Zheng, Ilse M. C. Vogels, Cornelis J. F. van Noorden, Reinier O. Schlingemann, Ingeborg Klaassen   +10 more
doaj   +1 more source

New Insight on 2D In Vitro Angiogenesis Models: All That Stretches Is Not a Tube

Cells, 2022
A Matrigel-based tube formation assay is a simple and widely accepted 2D angiogenesis model in vitro. Extracellular matrix (EM) proteins and growth factors (GFs) from MatrigelTM exclusively trigger endothelial cell (EC) tubular network (ETN) formation ...
Irina Beloglazova, Ekaterina Zubkova, Konstantin Dergilev, Yulia Goltseva, Yelena Parfyonova   +4 more
doaj   +1 more source

Receptor interacting protein 3 kinase, not 1 kinase, through MLKL-mediated necroptosis is involved in UVA-induced corneal endothelium cell death

Cell Death Discovery, 2021
Ultraviolet (UV) is one of the most energetic radiations in the solar spectrum that can result in various tissue injury disorders. Previous studies demonstrated that UVA, which represents 95% of incident photovoltaic radiation, induces corneal ...
Zhen Yu, Nikolaos E. Efstathiou, Victor S. M. C. Correa, Xiaohong Chen, Kenji Ishihara, Yasuhiro Iesato, Toshio Narimatsu, Dimitrios Ntentakis, Yanyun Chen, Demetrios G. Vavvas   +9 more
doaj   +1 more source

Computational modelling of angiogenesis: The importance of cell rearrangements during vascular growth [PDF]

WIREs Mechanisms of Disease, e1634 (2023), 2023
Angiogenesis is the process wherein endothelial cells (ECs) form sprouts that elongate from the pre-existing vasculature to create new vascular networks. In addition to its essential role in normal development, angiogenesis plays a vital role in pathologies such as cancer, diabetes and atherosclerosis.
arxiv   +1 more source

p53 expression as a prognostic marker in hepatocellular carcinoma [PDF]

Archives of Biological Sciences, 2014
Hepatocellular carcinoma (HCC) is one of the most frequent cancers worldwide with a high mortality. Immunohistochemical overexpression of the p53 protein was correlated with a poor prognosis in various human malignancies, including HCC.
Cioca Andreea, Cimpean Maria Anca, Kundnani Nilima Rajpal, Ceausu Raluca, Suciu Cristian, Raica Marius   +5 more
doaj   +1 more source

Local photoreceptor cell death differences in the murine model of retinal detachment

Scientific Reports, 2021
To investigate local cell death differences in the attached and detached retina at different regions in a murine experimental retinal detachment model. Subretinal injection of sodium hyaluronate was performed in eight-week-old C57BL/6J mice.
Daniel E. Maidana, Lucia Gonzalez-Buendia, Joan W. Miller, Demetrios G. Vavvas   +3 more
doaj   +1 more source

Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth

Journal of Experimental & Clinical Cancer Research, 2022
Background Mitochondrial fusion and fission proteins have been nominated as druggable targets in cancer. Whether their inhibition is efficacious in triple negative breast cancer (TNBC) that almost invariably develops chemoresistance is unknown.
Margherita Zamberlan, Amandine Boeckx, Florian Muller, Federica Vinelli, Olivier Ek, Caterina Vianello, Emeline Coart, Keitaro Shibata, Aurélie Christian, Francesca Grespi, Marta Giacomello, Ingrid Struman, Luca Scorrano, Stéphanie Herkenne   +13 more
doaj   +1 more source