Results 1 to 10 of about 705,764 (383)

Differential roles of eNOS in late effects of VEGF-A on hyperpermeability in different types of endothelial cells

Scientific Reports, 2023
Vascular endothelial growth factor (VEGF)-A induces endothelial hyperpermeability, but the molecular pathways remain incompletely understood. Endothelial nitric oxide synthase (eNOS) regulates acute effects of VEGF-A on permeability of endothelial cells (
Esmeralda K. Bosma, Shahan Darwesh, Yasmin I. Habani, Maxime Cammeraat, Paola Serrano Martinez, Mathilda E. van Breest Smallenburg, Jia Y. Zheng, Ilse M. C. Vogels, Cornelis J. F. van Noorden, Reinier O. Schlingemann, Ingeborg Klaassen   +10 more
doaj   +1 more source

Receptor interacting protein 3 kinase, not 1 kinase, through MLKL-mediated necroptosis is involved in UVA-induced corneal endothelium cell death

Cell Death Discovery, 2021
Ultraviolet (UV) is one of the most energetic radiations in the solar spectrum that can result in various tissue injury disorders. Previous studies demonstrated that UVA, which represents 95% of incident photovoltaic radiation, induces corneal ...
Zhen Yu, Nikolaos E. Efstathiou, Victor S. M. C. Correa, Xiaohong Chen, Kenji Ishihara, Yasuhiro Iesato, Toshio Narimatsu, Dimitrios Ntentakis, Yanyun Chen, Demetrios G. Vavvas   +9 more
doaj   +1 more source

New Insight on 2D In Vitro Angiogenesis Models: All That Stretches Is Not a Tube

Cells, 2022
A Matrigel-based tube formation assay is a simple and widely accepted 2D angiogenesis model in vitro. Extracellular matrix (EM) proteins and growth factors (GFs) from MatrigelTM exclusively trigger endothelial cell (EC) tubular network (ETN) formation ...
Irina Beloglazova, Ekaterina Zubkova, Konstantin Dergilev, Yulia Goltseva, Yelena Parfyonova   +4 more
doaj   +1 more source

Computational modelling of angiogenesis: The importance of cell rearrangements during vascular growth [PDF]

WIREs Mechanisms of Disease, e1634 (2023), 2023
Angiogenesis is the process wherein endothelial cells (ECs) form sprouts that elongate from the pre-existing vasculature to create new vascular networks. In addition to its essential role in normal development, angiogenesis plays a vital role in pathologies such as cancer, diabetes and atherosclerosis.
arxiv   +1 more source

p53 expression as a prognostic marker in hepatocellular carcinoma [PDF]

Archives of Biological Sciences, 2014
Hepatocellular carcinoma (HCC) is one of the most frequent cancers worldwide with a high mortality. Immunohistochemical overexpression of the p53 protein was correlated with a poor prognosis in various human malignancies, including HCC.
Cioca Andreea, Cimpean Maria Anca, Kundnani Nilima Rajpal, Ceausu Raluca, Suciu Cristian, Raica Marius   +5 more
doaj   +1 more source

Angiogenesis [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Extracellular matrix (ECM) is essential for all stages of angiogenesis. In the adult, angiogenesis begins with endothelial cell (EC) activation, degradation of vascular basement membrane, and vascular sprouting within interstitial matrix. During this sprouting phase, ECM binding to integrins provides critical signaling support for EC proliferation ...
Donald R, Senger, George E, Davis
openaire   +2 more sources

Local photoreceptor cell death differences in the murine model of retinal detachment

Scientific Reports, 2021
To investigate local cell death differences in the attached and detached retina at different regions in a murine experimental retinal detachment model. Subretinal injection of sodium hyaluronate was performed in eight-week-old C57BL/6J mice.
Daniel E. Maidana, Lucia Gonzalez-Buendia, Joan W. Miller, Demetrios G. Vavvas   +3 more
doaj   +1 more source

Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth

Journal of Experimental & Clinical Cancer Research, 2022
Background Mitochondrial fusion and fission proteins have been nominated as druggable targets in cancer. Whether their inhibition is efficacious in triple negative breast cancer (TNBC) that almost invariably develops chemoresistance is unknown.
Margherita Zamberlan, Amandine Boeckx, Florian Muller, Federica Vinelli, Olivier Ek, Caterina Vianello, Emeline Coart, Keitaro Shibata, Aurélie Christian, Francesca Grespi, Marta Giacomello, Ingrid Struman, Luca Scorrano, Stéphanie Herkenne   +13 more
doaj   +1 more source

VEGF dose controls the coupling of angiogenesis and osteogenesis in engineered bone

npj Regenerative Medicine, 2023
Vascular endothelial growth factor-A (VEGF) physiologically regulates both angiogenesis and osteogenesis, but its application in bone tissue engineering led to contradictory outcomes.
Andrea Grosso, Alexander Lunger, Maximilian G. Burger, Priscilla S. Briquez, Francesca Mai, Jeffrey A. Hubbell, Dirk J. Schaefer, Andrea Banfi, Nunzia Di Maggio   +8 more
doaj   +1 more source

Cancer cell survival depends on collagen uptake into tumor-associated stroma

Nature Communications, 2022
Collagen can be a metabolic source to fuel cancer growth. Here the authors show that cell surface protein TEM8 mediates the binding and uptake of collagen in stromal cells and these cells processed the collagen to glutamine, providing an alternative ...
Kuo-Sheng Hsu, James M. Dunleavey, Christopher Szot, Liping Yang, Mary Beth Hilton, Karen Morris, Steven Seaman, Yang Feng, Emily M. Lutz, Robert Koogle, Francesco Tomassoni-Ardori, Saurabh Saha, Xiaoyan M. Zhang, Enrique Zudaire, Pradip Bajgain, Joshua Rose, Zhongyu Zhu, Dimiter S. Dimitrov, Frank Cuttitta, Nancy J. Emenaker, Lino Tessarollo, Brad St. Croix   +21 more
doaj   +1 more source