Results 91 to 100 of about 3,183,533 (410)

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

New Advances in Targeted Therapy of HER2-Negative Breast Cancer

Frontiers in Oncology, 2022
Breast cancer has an extremely high incidence in women, and its morbidity and mortality rank first among female tumors. With the increasing development of molecular biology and genomics, molecular targeted therapy has become one of the most active areas ...
Junsha An, Cheng Peng, Xiaofang Xie, Fu Peng, Fu Peng   +4 more
doaj   +1 more source

Tumour Angiogenesis and Angiogenic Inhibitors: A Review.

Journal of clinical and diagnostic research : JCDR, 2015
Angiogenesis is a complex process depending on the coordination of many regulators and there by activating angiogenic switch. Recent advances in understanding of angiogenic mechanism have lead to the development of several anti-angiogenic and anti ...
Lalita Yadav, N. Puri, Varun Rastogi, P. Satpute, Vandana Sharma   +4 more
semanticscholar   +1 more source

The role of microenvironment in tumor angiogenesis

Journal of experimental & clinical cancer research : CR, 2020
Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis.
Xianjie Jiang, Jie Wang, Xiangying Deng, F. Xiong, Shanshan Zhang, Zhaojian Gong, Xiayu Li, K. Cao, H. Deng, Yi He, Q. Liao, Bo Xiang, Ming Zhou, Can Guo, Zhaoyang Zeng, Gui-yuan Li, Xiaoling Li, W. Xiong   +17 more
semanticscholar   +1 more source

Electrochemical sensing of angiogenin induced endothelial nitric oxide synthase activity [PDF]

, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009), Chang, SI, Chung, HM, Kang, DK, O'Hare, D, Trouillon, R   +5 more
core  

Ezetimibe Is an Inhibitor of Tumor Angiogenesis [PDF]

The American Journal of Pathology, 2009
Epidemiological and preclinical observations have suggested a role for one or more products of the mevalonate/cholesterol biosynthesis pathway in the progression of prostate cancer. In this study, we used ezetimibe (Zetia), a specific, FDA-approved, cholesterol uptake-blocking drug, in combination with either a hyper- or hypocholesterolemic diet, to ...
Jinsoo Joo, Keith R. Solomon, Keith R. Solomon, Kelly Boucher, Jayoung Kim, Jayoung Kim, Carl P. Schaffner, Kristine Pelton, David Zurakowski, Christopher Tully, Michael R. Freeman, Michael R. Freeman   +11 more
openaire   +2 more sources

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Exogenously added GPI-anchored tissue inhibitor of matrix metal loproteinase-1 (TIMP-1) displays enhanced and novel biological activities [PDF]

, 2004
The family of tissue inhibitors of metalloproteinases (TIMPs) exhibits diverse physiological/biological functions including the inhibition of active matrix metalloproteinases, regulation of proMMP activation, cell growth, and the modulation of ...
Banas B., Brew K., Dean D. D., Forough R., Galis Z. S., Gasson J. C., Gomez D. E., Guedez L., Itoh Y., Lijnen H. R., Medof M. E., Opdenakker G., Yamada E.   +12 more
core   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

A unique role for galectin-9 in angiogenesis and inflammatory arthritis

Arthritis Research & Therapy, 2018
Background Galectin-9 (Gal-9) is a mammalian lectin secreted by endothelial cells that is highly expressed in rheumatoid arthritis synovial tissues and synovial fluid.
Martin J. O’Brien, Qiang Shu, W.Alexander Stinson, Pei-Suen Tsou, Jeffrey H. Ruth, Takeo Isozaki, Phillip L. Campbell, Ray A. Ohara, Alisa E. Koch, David A. Fox, M. Asif Amin   +10 more
doaj   +1 more source