Results 141 to 150 of about 322,587 (327)

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

Current Status of Angiogenesis Inhibitors as Second-Line Treatment for Unresectable Colorectal Cancer. [PDF]

Cancers (Basel), 2023
Otsu S, Hironaka S.
europepmc   +1 more source

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. [PDF]

, 2008
The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly for combinations of ...
Aizenstein, Brian, Apsel, Beth, Blair, Jimmy A, Feldman, Morri E, Gonzalez, Beatriz, Hoffman, Randy, Knight, Zachary A, Nazif, Tamim M, Shokat, Kevan M, Williams, Roger L   +9 more
core  

Supplementary Materials, Figures 1-7, Table 1 from A Novel Sialyltransferase Inhibitor Suppresses FAK/Paxillin Signaling and Cancer Angiogenesis and Metastasis Pathways

, 2023
Jiayang Chen, Yen‐An Tang, Sin‐Ming Huang, Hsueh‐Fen Juan, Li‐Wha Wu, Ying‐Chieh Sun, Szu-Chi Wang, Kuan‐Wei Wu, Balraj Gopula, Tzu‐Ting Chang, Wen‐Shan Li, Hung‐Chi Cheng, Yi‐Ching Wang   +12 more
openalex   +2 more sources

A Novel Sprayable Fibrinogen/Glycosaminoglycans/Collagen‐Based Bioink for Skin Wound Healing Applied by a Handheld Dual‐Head Airbrush

Advanced Healthcare Materials, EarlyView.
A dual‐head airbrush‐based spraying device, combined with a fibrinogen bioink enriched with glycosaminoglycans and collagen, enables the delivery of biomaterials and cells to promote wound healing. This system demonstrates effective skin regeneration in vitro and in vivo, with comparable results to autografts.
Paula Pleguezuelos‐Beltrán, Daniel Nieto‐García, Carlos Chocarro‐Wrona, Juan de Vicente, Patricia Gálvez‐Martín, José Manuel Entrena, Elena López‐Ruiz, Juan Antonio Marchal   +7 more
wiley   +1 more source

Anti(angiogenic) food components: can be a major source of bias in the investigation of angiogenesis inhibitors. [PDF]

Ann Transl Med, 2023
Rastmanesh R, Bowirrat A, Gupta A, Gilley E, Blum K.   +4 more
europepmc   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Therapeutic targeting of protein arginine methyltransferases reduces breast cancer progression by disrupting angiogenic pathways

Biochemistry and Biophysics Reports
Protein arginine methylation is an epigenetic modification involved in transcription, splicing and signal transduction and is mediated by protein arginine methyltransferases (PRMTs).
Kamohelo Maphalala, Dakalo Portia Ramali, Lorraine Tshegofatso Maebele, Thanyani Victor Mulaudzi, Peace Mabeta, Zodwa Dlamini, Botle Precious Damane   +6 more
doaj   +1 more source

Angiogenesis inhibitors for the treatment of epithelial ovarian cancer. [PDF]

Cochrane Database Syst Rev, 2023
Gaitskell K, Rogozińska E, Platt S, Chen Y, Abd El Aziz M, Tattersall A, Morrison J.   +6 more
europepmc   +1 more source

Fumarate Esters as Angiogenesis Inhibitors: Key to Action in Psoriasis? [PDF]

, 2011
Jack L. Arbiser
openalex   +1 more source