Results 51 to 60 of about 5,168 (136)

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Angioimmunoblastic T-cell Lymphoma: A Mimic for Lupus

European Journal of Case Reports in Internal Medicine, 2020
New-onset systemic lupus erythematosus (SLE) is uncommon in elderly patients. We report the case of a 71-year-old woman who was diagnosed with SLE based on clinical manifestations of fever, alopecia, bicytopenia, hepatomegaly, lymphadenopathy ...
Hui Boon Tay, Stanley Angkodjojo, Zhi En Amos Tay, Puay Hoon Tan, Yan Denise Tan   +4 more
doaj   +1 more source

Complete hematologic response after belinostat treatment and allogeneic stem cell transplantation for multiple relapsed/refractory angioimmunoblastic T‐cell lymphoma: A case report

Clinical Case Reports, 2023
Key Clinical Message This case report highlights the potential of belinostat for the treatment of relapsed/refractory peripheral T‐cell lymphomas, for which effective therapies are still scarce.
Vincent Camus, Pascaline Etancelin, Fanny Drieux, Elena‐Liana Veresezan, Jean‐Michel Picquenot, Dominique Penther, Mathieu Viennot, Philippe Ruminy, Nathalie Contentin, Emilie Lemasle, Stéphane Leprêtre, Sydney Dubois, Juliette Penichoux, Aspasia Stamatoullas, Alexandra Zduniak, Hélène Lanic, Fabrice Jardin   +16 more
doaj   +1 more source

Exploiting ALK inhibition in anaplastic large cell lymphoma: Biological rationale and therapeutic integration

British Journal of Haematology, Volume 208, Issue 5, Page 1525-1534, May 2026.
Summary Mature T‐cell lymphomas comprise a heterogeneous group of aggressive non‐Hodgkin lymphomas with limited therapeutic options in the relapsed or refractory setting. Among them, anaplastic lymphoma kinase (ALK)‐positive anaplastic large cell lymphoma (ALCL) represents a biologically distinct subtype driven by constitutive activation of ALK fusion ...
Santino Caserta, Enrica Antonia Martino, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Marco Fiorillo, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +13 more
wiley   +1 more source

Incidence of Hodgkin and Non‐Hodgkin Lymphomas: Comparison of the Military and General Population

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Background Lymphoma risk varies by demographics, environmental/occupational exposures, and medical care between active‐duty service members (ADSM) and the general US population (GUSP). This study compared age‐adjusted incidence rates and trends of Hodgkin lymphoma (HL) and non‐Hodgkin lymphoma (NHL) between these groups.
Kimberly R. Robins, Julie A. Bytnar, Christin B. DeStefano, Craig D. Shriver, Kangmin Zhu   +4 more
wiley   +1 more source

Peripheral Lymphocytosis in Angioimmunoblastic T-cell Lymphoma

International Journal of Advanced Medical and Health Research
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive and unique type of T-cell lymphoma. Patients typically present with constitutional B symptoms, generalized lymphadenopathy, hepatosplenomegaly, cytopenias, and rash.
C. Selvapriya, Nidhya Ganesan, Sakthisankari Shanmugasundaram, Narmadha Rathinasamy, Prasanna Nedungadi Kumar   +4 more
doaj   +1 more source

Erdheim‐Chester disease associated with myeloid neoplasm: Clinical features, molecular landscape, and treatment outcomes

HemaSphere, Volume 10, Issue 4, April 2026.
Abstract Erdheim‐Chester disease (ECD) is frequently associated with clonal hematopoiesis and myeloid neoplasms (MN), but clinical phenotype and response to kinase inhibitors (KI) in this setting remain unclear. We analyzed 67 patients with ECD associated with MN (ECD‐MN) from a French national cohort and assessed ECD treatment response, MN progression,
Ambroise Le Pogam, Matthias Papo, Pierre Hirsch, Fleur Cohen‐Aubart, Jean‐François Emile, François Delhommeau, Pierre Duffau, Jérôme Razanamahery, Florence Nguyen‐Khac, Christopher Nunes Gomes, Felicien Triboulet, Jeanne de La Rochefoucauld, Chloé McAvoy, Estibaliz Lazaro, Mehdi Hage‐Sleiman, Damien Roos‐Weil, François Chasset, Vincent Jachiet, Arsène Mekinian, Olivier Fain, Zahir Amoura, Jérôme Hadjadj, Julien Haroche   +22 more
wiley   +1 more source

Upregulated Neuro-oncological Ventral Antigen 1 (NOVA1) Expression Is Specific to Mature and Immature T- and NK-Cell Lymphomas [PDF]

Journal of Pathology and Translational Medicine, 2016
Background: Recent studies have revealed that the splicing factor neuro-oncological ventral antigen 1 (NOVA1) is enriched in fibroblasts and accumulated T cells of tertiary lymphoid structures.
Eun Kyung Kim, Sun Och Yoon, Soo Hee Kim, Woo Ick Yang, Yoon Ah Cho, Soo Jeong Kim   +5 more
doaj   +1 more source

Advancing the Diagnosis of Non‐Hodgkin Lymphoma Through Next‐Generation Sequencing in Developing Countries: An Evaluation of Progress—A Narrative Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Non‐Hodgkin lymphoma (NHL) is the most prevalent hematological malignancy worldwide and accounts for approximately 3% of all cancer cases and fatalities. Next‐generation sequencing (NGS) has advanced molecular diagnosis and targeted treatment in developed countries.
Mohammadreza Saeidnia, Mehdi Shokri, Hassan Nourmohammadi, Safa Radmehr, Mashallah Babashahi, Mohamad Moradi, Maryam Karimian, Mohammad Panji, Elahe Motevaseli   +8 more
wiley   +1 more source

Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma

Haematologica, 2007
Background and Objectives In the present paper we report that SAP, an intracytoplasmic molecule that is involved in cell signaling, is an immunohistologic marker for germinal center T cells in paraffin-embedded tissue.
Giovanna Roncador, José-Francisco García Verdes-Montenegro, Sara Tedoldi, Jennifer C. Paterson, Wolfram Klapper, Erica Ballabio, Lorena Maestre, Stefano Pileri, Martin-Leo Hansmann, Miguel A. Piris, David Y. Mason, Teresa Marafioti   +11 more
doaj   +1 more source