Results 21 to 30 of about 19,335,204 (179)

Targeting metabolic flexibility via angiopoietin-like 4 protein sensitizes metastatic cancer cells to chemotherapy drugs

open access: yesMolecular Cancer, 2018
Overcoming multidrug resistance has always been a major challenge in cancer treatment. Recent evidence suggested epithelial-mesenchymal transition plays a role in MDR, but the mechanism behind this link remains unclear.
Maegan Miang Kee Lim   +10 more
doaj   +1 more source

Serum levels of angiopoietin-like protein 4 in polycystic ovary syndrome women with normal body mass index [PDF]

open access: yesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2018
Introduction: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder in women, and approximately 75% of women affected by PCOS are overweight. Angiopoietin-like protein 4 (ANGPTL4) is a potent inhibitor of lipoprotein lipase (LPL) enzyme.
Elham Rahmani   +6 more
doaj   +1 more source

Association of a genetic variant in the angiopoietin-like protein 4 gene with metabolic syndrome

open access: yesBMC Medical Genetics, 2019
Background Metabolic syndrome (MetS) is characterized by a clustering of cardiovascular risk factors that include: abdominal obesity, dyslipidemia, hypertension and glucose intolerance.
Sara Kharazmi-Khorassani   +9 more
doaj   +1 more source

Skeletal Muscle Angiopoietin-Like Protein 4 and Glucose Metabolism in Older Adults after Exercise and Weight Loss

open access: yesMetabolites, 2020
Angiopoietin-like protein 4 (ANGPTL4) is an adipokine that plays an important role in energy homoeostasis and lipid and lipoprotein metabolism. This study was designed to determine the effect of an exercise plus weight loss intervention on ANGPTL4 ...
Guoyan Li, Hefang Zhang, Alice S. Ryan
doaj   +1 more source

Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through angiopoietin-like protein 4

open access: yesGenes and Diseases, 2022
Podocyte injury is an important cause of proteinuria. Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein and has a role in proteinuria. However, the exact role of Angptl4 in podocyte injury and its upstream regulators has not been clarified.
Xiujin Shen   +9 more
doaj   +1 more source

A randomised, controlled, crossover study of the effect of diet on angiopoietin-like protein 4 (ANGPTL4) through modification of the gut microbiome

open access: yesJournal of Nutritional Science, 2016
Angiopoietin-like protein 4 (ANGPTL4) is a lipoprotein lipase inhibitor that is involved in lipid metabolism and angiogenesis. Animal studies have suggested that the ANGPTL4 protein is modulated by the gut microbiota, possibly through increased ...
Trine Blædel   +9 more
doaj   +1 more source

Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4). [PDF]

open access: yesPLoS ONE, 2010
BACKGROUND: Intervention strategies for obesity are global issues that require immediate attention. One approach is to exploit the growing consensus that beneficial gut microbiota could be of use in intervention regimes.
Linda Aronsson   +8 more
doaj   +1 more source

ANGPTL4 Expression in Ovarian Granulosa Cells Is Associated With Polycystic Ovary Syndrome

open access: yesFrontiers in Endocrinology, 2022
ObjectivesThis study aims to characterize the expression of ANGPTL4 in ovarian granulosa cells (GCs) and its association with polycystic ovary syndrome (PCOS).MethodsThis study included 104 PCOS patients and 112 women in control group undergoing in vitro
Qi Jiang   +33 more
doaj   +1 more source

Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis.

open access: yes, 2011
OBJECTIVE: To determine the utility of angiopoietin-1 and angiopoietin-2 as potentially novel biomarkers of morbidity and mortality in patients with severe sepsis. DESIGN: Multicenter longitudinal cohort study.
Hawkes, Michael   +25 more
core   +1 more source

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis [PDF]

open access: yes, 2003
We have investigated the function of mitotic kinesin-like protein (MKlp) 2, a kinesin localized to the central spindle, and demonstrate that its depletion results in a failure of cleavage furrow ingression and cytokinesis, and disrupts localization of ...
Mayer, Thomas U.   +20 more
core   +1 more source

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