Results 151 to 160 of about 107,707,414 (242)

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3079-3105, November 2026.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Angiopoietin-1 [PDF]

, 2020
openaire   +1 more source

Further Insights Into the Mechanisms of Lymph Node Metastasis

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Metastasis of malignant tumors arising from epithelial organs to sentinel lymph nodes has important implications for prognosis, staging, and therapeutic decision‐making. Recent insights into anatomic pathways, pathogenesis, molecular interactions, and genetic factors have encouraged scientists and clinicians to develop drugs that target ...
S. David Nathanson, Meghan J. O'Melia, Kelly C. Rosso, Ian S. Wood, Drishti Lall, Jenny T. Bui   +5 more
wiley   +1 more source

COMP-Angiopoietin-1 decreases lipopolysaccharide-induced acute kidney injury

, 2009
During sepsis endothelial dysfunction is an important pathogenetic mechanism in acute kidney injury (AKI). Lipopolysaccharide (LPS)-induced endotoxemia is associated with renal hemodynamic changes such as alterations of renal blood flow (RBF), vascular ...
Jang, Kyu Yun, Lee, Tae Hwan, Choi, Kyu-Sil, Park, Sung Kwang, Sung, Mi Jeong, Lee, Sik, Kim, Won, Jung, Yu Jin, Lee, Sang Yong, Moon, Woo Sung, Yoon, Kwon-Ha, Kang, Kyung Pyo, Kim, Duk Hoon, Lee, Ae Sin   +13 more
core   +1 more source

Predicting cardiovascular disease in peritoneal dialysis patients using glycated proteomics and machine learning: A prospective multicentre study

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Graphical Headlights 1. Glycated proteomics identified candidate cardiovascular biomarkers in peritoneal dialysis patients. 2. A machine learning model integrated two glycated peptides with six clinical indicators. 3. The model achieved ROC‐AUCs of 0.781 in the internal testing set and 0.822 in multicentre external validation.
Ji Ji, Zhaoying Nie, Na Jiang, Ting Xie, Lei Zhang, Xiaoyan Liu, Min Lu, Bo Xiang, Weiwei Wu, Xiaotian Jiang, Lin Zhang, Jun Ji, Jianzhou Zou, Xiaoqiang Ding, Haojie Lu, Xiaofang Yu   +15 more
wiley   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source

Claudin‐12‐Expressing Fibroblasts Facilitate Metastatic Spread of Pancreatic Cancer Through Physical Interactions

MedComm, Volume 7, Issue 11, November 2026.
Tumor‐derived TGF‐β induces CLDN12 expression in cancer‐associated fibroblasts, enabling direct adhesion to pancreatic cancer cells through homophilic CLDN12 interactions, thereby promoting local invasion into adjacent tissues and metastasis to the liver; blockade with C12‐pm suppresses liver metastasis.
Qingcui Li, Xiangjing Miao, Yuanyuan Yang, Ruoyang Chen, Qingqing Fang, Xixi Duan, Xiaohan Lou, Xiaohan Yao, Lijing Zhang, Rainer Glauben, Zhihai Qin, Chen Ni   +11 more
wiley   +1 more source

Angiopoietin-1 Receptor [PDF]

, 2020
openaire   +1 more source

Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. [PDF]

Front Cell Neurosci, 2023
Chen YC, Martins TA, Marchica V, Panula P.   +3 more
europepmc   +1 more source

Dysregulated TIE‐2 expression is associated with blood‐brain barrier leakiness and Alzheimer's disease‐related neuropathology

Brain Pathology, Volume 36, Issue 6, November 2026.
Ince et al., have analysed TIE‐1 and ‐2 expression in human brain tissue, including microvessel‐enriched fractions (MVF) and covering a spectrum of AD‐associated pathology, and in CSF from independent cohorts spanning a clinical spectrum from normal cognition to AD.
Selvi Ince, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Carey Gleason, Barbara B. Bendlin, Ozioma Okonkwo, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Seth Love, J. Scott Miners   +12 more
wiley   +1 more source