Results 191 to 200 of about 97,423,779 (276)

Angiopoietin-2 aggravates Alzheimer's disease by promoting blood-brain barrier dysfunction and neuroinflammation. [PDF]

Cell Rep
Lee E, Kim S, Zhu CL, Acquarone E, Kim S, Lo A, Omar OMF, Taddese M, Gradinaru V, Murphy PA, Agalliu D, Arancio O, An JY, Kim M.   +13 more
europepmc   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, Volume 7, Issue 5, October 2026.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Serum angiopoietin-1 and angiopoietin-2 levels in Turkish patients with Behçet's disease: associations with clinical manifestations and inflammatory markers. [PDF]

Turk J Med Sci
Gücenmez S, Emmungil H, Yargucu Zihni F, Keser G, Aksu K.   +4 more
europepmc   +1 more source

From Regenerative to Degenerative Niche: Multicellular Crosstalk and Population Dynamics in Skeletal Muscle Aging

Aging Cell, Volume 25, Issue 10, October 2026.
Aging transforms the skeletal muscle microenvironment from a balanced, regenerative niche into a maladaptive, degenerative state. This review highlights how disrupted multicellular crosstalk drives chronic inflammation, fibrosis, and neuromuscular dysfunction, ultimately compromising tissue repair and fueling sarcopenia.
Seongwan Kim, Min Ju Kim, Yong Ryoul Yang   +2 more
wiley   +1 more source

MAPK signaling and angiopoietin-2 contribute to endothelial permeability in capillary malformations. [PDF]

Proc Natl Acad Sci U S A
Nasim S, Baig M, Wylie-Sears J, Vivero MP, Smits P, Holm A, Marrs L, Cheng YS, Alves C, Pinto A, Greene AK, Bischoff J.   +11 more
europepmc   +1 more source

Insights into the modulation of age‐related macular degeneration: Molecular and systems‐level perspectives

Acta Ophthalmologica, Volume 104, Issue S293, Page S4-S35, October 2026.
ENGLISH SUMMARY In developed countries, age‐related macular degeneration (AMD) is the leading cause of visual impairment in the aging population. Understanding of its pathogenesis is limited and the number of patients is predicted to continue rising. AMD is classified into two main forms: dry and neovascular AMD (dAMD and nAMD, respectively).
Hanna Heloterä
wiley   +1 more source

Loss of angiopoietin-2 leads to region-specific brain malformations and blood-brain barrier leakage. [PDF]

JCI Insight
Li W, Vázquez-Liébanas E, Fébrissy C, Sauvé F, Wang J, Sayıner DE, Buslaps P, Norrén A, Vanlandewijck M, He L, Jeansson M, Muhl L, Mäe MA.   +12 more
europepmc   +1 more source

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, Volume 59, Issue 10, October 2026.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Association of Serum Angiopoietin-2 With Kidney Function Decline Among Participants in the Multiethnic Study of Atherosclerosis (MESA) Cohort. [PDF]

Kidney Med
Assefa M, Zelnick L, Kestenbaum B, Liles WC, Leary PJ, Bansal N, Bhatraju PK.   +6 more
europepmc   +1 more source

Optimal Hypoxia Mimetic Small Molecules for Enhancing Angiogenic Properties of Stem Cells From Human Exfoliated Deciduous Teeth

International Endodontic Journal, Volume 59, Issue 10, Page 2122-2142, October 2026.
ABSTRACT Aim Hypoxic preconditioning of cells holds promise for regenerative therapies, yet identifying effective and safe methods for clinical application remains challenging. We aimed to determine optimal hypoxia‐mimetic small molecules (SMs) that stabilize hypoxia‐inducible factor‐1α (HIF‐1α) and their dosages for hypoxic preconditioning in stem ...
Hong Wang, Jiawei Liu, Xintao Yang, Mohamad Koohi‐Moghadam, Shuting Gao, Yuanyuan Han, Dineshi Sewvandi Thalakiriyawa, James Kit Hon Tsoi, Yanqi Yang, Waruna Lakmal Dissanayaka   +9 more
wiley   +1 more source