Results 161 to 170 of about 22,958 (190)
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Triglyceride metabolism and angiopoietin-like proteins in lipoprotein lipase regulation
Clinica Chimica Acta, 2020Hypertriglyceridemia is a risk factor for a series of diseases, such as cardiovascular disease (CVD), diabetes and nonalcoholic fatty liver disease (NAFLD). Angiopoietin-like proteins (ANGPTLs) family, especially ANGPTL3, ANGPTL4 and ANGPTL8, which regulate lipoprotein lipase (LPL) activity, play pivotal roles in triglyceride (TG) metabolism and ...
Wei Xie, Suyun Li, Mengqian Huang
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Modulation of plasma TG lipolysis by Angiopoietin-like proteins and GPIHBP1
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2010There is evidence that elevated plasma triglycerides (TG) serve as an independent risk factor for coronary heart disease. Plasma TG levels are determined by the balance between the rate of production of chylomicrons and VLDL in intestine and liver, respectively, and their rate of clearance in peripheral tissues.
Laeticia Lichtenstein, Sander Kersten
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Egyptian Pharmaceutical Journal, 2023
Background Obesity has recently been identified as a risk factor for coronavirus disease-19. There is a significant correlation between obesity rates with metabolic syndrome and coronavirus disease-19 in children worldwide. Owing to the high expression in adipose tissue, angiopoietin-like protein 5 (ANGPTL5) might be assumed to
Mai S. ElShiekh +7 more
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Background Obesity has recently been identified as a risk factor for coronavirus disease-19. There is a significant correlation between obesity rates with metabolic syndrome and coronavirus disease-19 in children worldwide. Owing to the high expression in adipose tissue, angiopoietin-like protein 5 (ANGPTL5) might be assumed to
Mai S. ElShiekh +7 more
openaire +1 more source
Angiopoietin-like proteins and postprandial partitioning of fatty acids
Current Opinion in Lipidology, 2021Purpose of review Over the last two decades, evolving discoveries around angiopoietin-like (ANGPTL) proteins, particularly ANGPTL3, ANGPTL4, and ANGPTL8, have generated significant interest in understanding their roles in fatty acid (FA) metabolism.
Nicole M, DiDonna +2 more
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Regulation of lipid metabolism by angiopoietin-like proteins
Current Opinion in Lipidology, 2016The angiopoietin-like proteins (ANGPTLs) 3, 4 and 8 have emerged as key regulators of plasma lipid metabolism by serving as potent inhibitors of the enzyme lipoprotein lipase (LPL). In this review, we provide an integrated picture of the role of ANGPTL3, ANGPTL4 and ANGPTL8 in lipid metabolism by focusing on their impact on LPL activity and plasma ...
Dijk, Wieneke, Kersten, Sander
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The angiopoietin-like protein 3
Current Opinion in Lipidology, 2013Cumulating evidence are revealing roles of angiopoietin-like proteins (ANGPTLs) in lipid, glucose, and energy metabolism. In this review, we discuss the recent developments in understanding the specific role in metabolic processes of the liver-derived ANGPTL3.Several groups have reported clinical and metabolic characterization of individuals with loss ...
ARCA, Marcello +2 more
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Angiopoietin-Like Proteins and Lipid Metabolism
2009Lipoprotein lipase, hepatic lipase, and endothelial lipase play a pivotal role in the clearance and remodelling of plasma lipoproteins. Their activity is governed at the level of gene transcription as well as via changes in enzyme activity by specific activator or inhibitor proteins.
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Familial combined hypolipidemia: angiopoietin-like protein-3 deficiency
Current Opinion in Lipidology, 2020Purpose of review Angiopoietin-like protein-3 (ANGPTL3) is emerging as a key player in lipoprotein transport with an expanding role on fatty acid and glucose metabolism. Its deficiency is associated with a favorable metabolic profile.
Arca M., D'Erasmo L., Minicocci I.
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Angiopoietin-like 3: An important protein in regulating lipoprotein levels
Best Practice & Research Clinical Endocrinology & Metabolism, 2023ANGPTL3 has emerged as a therapeutic target whose inhibition results in profound reductions of plasma lipids, including atherogenic triglyceride-rich lipoproteins and low-density lipoprotein cholesterol. The identification of ANGPTL3 deficiency as a cause of familial combined hypolipidemia in humans hastened the development of anti-ANGPTL3 therapeutic ...
Kendall H, Burks +3 more
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Response of Angiopoietin-like Proteins 3 and 4 to Hemodialysis
The International Journal of Artificial Organs, 2014Background/Aim Patients on chronic hemodialysis (cHD) have decreased activity of lipoprotein lipase (LPL). Angiopoietin-like proteins (ANGPTL) 3 and 4 have been shown to inactivate LPL. The aim of this study was to investigate the levels of the ANGPTLs in plasma of cHD-patients and to evaluate if cHD may alter ...
Dana, Mahmood +4 more
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