Results 171 to 180 of about 22,958 (190)
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The role of angiopoietin-like protein 2 in pathogenesis of dermatomyositis
Biochemical and Biophysical Research Communications, 2012Dermatomyositis (DM) is an autoimmune disease marked by chronic inflammation of skin and muscle tissues and characterized clinically by proximal muscle weakness and skin eruption, including heliotrope rash, and Gottron's sign. Treatment with a non-specific immunosuppressive agent or anti-inflammatory corticosteroids is beneficial, although some ...
Aki, Ogata +10 more
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Angiopoietin-like proteins: Another player in the metabolic field
Journal of Hepatology, 2006Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Oike Y, Akao M, Yasunaga K, Yamauchi T, Morisada T, Ito Y, Urano T, Kimura Y, Kubota Y, Maekawa H, Miyamoto T, Miyata K, Matsumoto S, Sakai J, Nakagata N, Takeya M, Koseki H, Ogawa Y, Kadowaki T, Suda T. Angiopoietin-related growth factor (AGF), a member of the angiopoietin-
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Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation
Metabolism, 2017Several studies have reported that angiopoietin-like protein 2 (Angptl2) is expressed abundantly in adipocytes and is associated with adipose tissue inflammation. In the present study, we found that osteoblasts and mesenchymal stem cells also expressed Angptl2 at high levels.
Aiko, Takano +8 more
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Regulation of lipid metabolism via angiopoietin-like proteins
Biochemical Society Transactions, 2005Regulation of mammalian energy metabolism is an intricate process involving numerous hormones, transcription factors and signal transduction cascades. Much of the regulation occurs via secreted factors that relay information from one organ to another.
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Angiopoietin like protein 4 expression is decreased in activated macrophages
Biochemical and Biophysical Research Communications, 2012Angiopoietin like protein 4 (ANGPTL4) inhibits lipoprotein lipase (LPL) activity. Previous studies have shown that Toll-like Receptor (TLR) activation increases serum levels of ANGPTL4 and expression of ANGPTL4 in liver, heart, muscle, and adipose tissue in mice.
Kenneth R, Feingold +4 more
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Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events
Current Opinion in Lipidology, 2010Angiopoietin-like proteins (Angptls) comprise a family of secreted glycoproteins with high homology to angiopoietins which are important regulators of angiogenesis. Angptl3 and Angptl4 inhibit lipoprotein lipase in mice. This article reviews recent human studies on Angptls and their effects on lipoprotein profiles and cardiovascular disease.Population ...
Takashi, Miida, Satoshi, Hirayama
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Genetics and regulation of angiopoietin-like proteins 3 and 4
Current Opinion in Lipidology, 2006Lipoprotein lipase activity in a given tissue is the rate limiting step for the uptake of triglyceride-derived fatty acids. Imbalances in the partitioning of fatty acids have major metabolic consequences. Given the central role of lipoprotein lipase in energy metabolism, the discovery of new molecules that affect the activity of lipoprotein lipase ...
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A tale of two angiopoietin-like proteins
Current Opinion in Lipidology, 2007openaire +2 more sources