Results 201 to 210 of about 164,168 (220)

Roles of angiopoietin-like proteins in regulation of stem cell activity [PDF]

Journal of Biochemistry, 2019
Abstract Various types of stem cells reside in the body and self-renew throughout an organism’s lifetime. Such self-renewal is essential for maintenance of tissue homeostasis and is co-ordinately regulated by stem cell-intrinsic signals and signals from stem cell niche. Angiopoietin is a niche-derived signalling molecule well known to
Tsuyoshi Kadomatsu, Yuichi Oike, Kadomatsu Tsuyoshi   +2 more
exaly   +3 more sources

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The role of angiopoietin-like protein 2 in pathogenesis of dermatomyositis

Biochemical and Biophysical Research Communications, 2012
Dermatomyositis (DM) is an autoimmune disease marked by chronic inflammation of skin and muscle tissues and characterized clinically by proximal muscle weakness and skin eruption, including heliotrope rash, and Gottron's sign. Treatment with a non-specific immunosuppressive agent or anti-inflammatory corticosteroids is beneficial, although some ...
Aki, Ogata, Motoyoshi, Endo, Jun, Aoi, Otowa, Takahashi, Tsuyoshi, Kadomatsu, Keishi, Miyata, Zhe, Tian, Masatoshi, Jinnin, Satoshi, Fukushima, Hironobu, Ihn, Yuichi, Oike   +10 more
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Modulation of plasma TG lipolysis by Angiopoietin-like proteins and GPIHBP1

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2010
There is evidence that elevated plasma triglycerides (TG) serve as an independent risk factor for coronary heart disease. Plasma TG levels are determined by the balance between the rate of production of chylomicrons and VLDL in intestine and liver, respectively, and their rate of clearance in peripheral tissues.
Laeticia Lichtenstein, Sander Kersten
exaly   +4 more sources

Angiopoietin-like proteins: Another player in the metabolic field

Journal of Hepatology, 2006
Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Oike Y, Akao M, Yasunaga K, Yamauchi T, Morisada T, Ito Y, Urano T, Kimura Y, Kubota Y, Maekawa H, Miyamoto T, Miyata K, Matsumoto S, Sakai J, Nakagata N, Takeya M, Koseki H, Ogawa Y, Kadowaki T, Suda T. Angiopoietin-related growth factor (AGF), a member of the angiopoietin-
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Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation

Metabolism, 2017
Several studies have reported that angiopoietin-like protein 2 (Angptl2) is expressed abundantly in adipocytes and is associated with adipose tissue inflammation. In the present study, we found that osteoblasts and mesenchymal stem cells also expressed Angptl2 at high levels.
Aiko, Takano, Takao, Fukuda, Takanori, Shinjo, Misaki, Iwashita, Etsuko, Matsuzaki, Kensuke, Yamamichi, Masaaki, Takeshita, Terukazu, Sanui, Fusanori, Nishimura   +8 more
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Angiopoietin like protein 4 expression is decreased in activated macrophages

Biochemical and Biophysical Research Communications, 2012
Angiopoietin like protein 4 (ANGPTL4) inhibits lipoprotein lipase (LPL) activity. Previous studies have shown that Toll-like Receptor (TLR) activation increases serum levels of ANGPTL4 and expression of ANGPTL4 in liver, heart, muscle, and adipose tissue in mice.
Kenneth R, Feingold, Judy K, Shigenaga, Andrew S, Cross, Arthur, Moser, Carl, Grunfeld   +4 more
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Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events

Current Opinion in Lipidology, 2010
Angiopoietin-like proteins (Angptls) comprise a family of secreted glycoproteins with high homology to angiopoietins which are important regulators of angiogenesis. Angptl3 and Angptl4 inhibit lipoprotein lipase in mice. This article reviews recent human studies on Angptls and their effects on lipoprotein profiles and cardiovascular disease.Population ...
Takashi, Miida, Satoshi, Hirayama
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Genetics and regulation of angiopoietin-like proteins 3 and 4

Current Opinion in Lipidology, 2006
Lipoprotein lipase activity in a given tissue is the rate limiting step for the uptake of triglyceride-derived fatty acids. Imbalances in the partitioning of fatty acids have major metabolic consequences. Given the central role of lipoprotein lipase in energy metabolism, the discovery of new molecules that affect the activity of lipoprotein lipase ...
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Serum angiopoietin-like protein 3 concentrations in rheumatic diseases

European Journal of Dermatology, 2012
Angiopoietin-like protein 3 (Angptl3) is one of the angiogenic cytokines that stimulates endothelial cell adhesion, migration, and neovascularization. No link has been established between Angptl3 and rheumatic diseases such as systemic sclerosis or dermatomyositis (DM).
Yasuyo, Hayashi, Masatoshi, Jinnin, Takamitsu, Makino, Ikko, Kajihara, Katsunari, Makino, Noritoshi, Honda, Wakana, Nakayama, Kuniko, Inoue, Satoshi, Fukushima, Hironobu, Ihn   +9 more
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Structure and Function of Angiopoietin-like Protein 3 (ANGPTL3) in Atherosclerosis

Current Medicinal Chemistry, 2020
Background: Angiopoietin-Like Proteins (ANGPTLs) are structurally related to the angiopoietins. A total of eight ANGPTLs (from ANGPTL1 to ANGPTL8) have been identified so far. Most ANGPTLs possess multibiological functions on lipid metabolism, atherosclerosis, and cancer.
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