Results 201 to 210 of about 5,909,528 (224)
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Genetics and regulation of angiopoietin-like proteins 3 and 4
Current Opinion in Lipidology, 2006Lipoprotein lipase activity in a given tissue is the rate limiting step for the uptake of triglyceride-derived fatty acids. Imbalances in the partitioning of fatty acids have major metabolic consequences. Given the central role of lipoprotein lipase in energy metabolism, the discovery of new molecules that affect the activity of lipoprotein lipase ...
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Serum angiopoietin-like protein 3 concentrations in rheumatic diseases
European Journal of Dermatology, 2012Angiopoietin-like protein 3 (Angptl3) is one of the angiogenic cytokines that stimulates endothelial cell adhesion, migration, and neovascularization. No link has been established between Angptl3 and rheumatic diseases such as systemic sclerosis or dermatomyositis (DM).
Yasuyo, Hayashi +9 more
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Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation
Metabolism, 2017Several studies have reported that angiopoietin-like protein 2 (Angptl2) is expressed abundantly in adipocytes and is associated with adipose tissue inflammation. In the present study, we found that osteoblasts and mesenchymal stem cells also expressed Angptl2 at high levels.
Aiko, Takano +8 more
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Angiopoietin like protein 4 expression is decreased in activated macrophages
Biochemical and Biophysical Research Communications, 2012Angiopoietin like protein 4 (ANGPTL4) inhibits lipoprotein lipase (LPL) activity. Previous studies have shown that Toll-like Receptor (TLR) activation increases serum levels of ANGPTL4 and expression of ANGPTL4 in liver, heart, muscle, and adipose tissue in mice.
Kenneth R, Feingold +4 more
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Angiopoietin-like proteins: Another player in the metabolic field
Journal of Hepatology, 2006Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Oike Y, Akao M, Yasunaga K, Yamauchi T, Morisada T, Ito Y, Urano T, Kimura Y, Kubota Y, Maekawa H, Miyamoto T, Miyata K, Matsumoto S, Sakai J, Nakagata N, Takeya M, Koseki H, Ogawa Y, Kadowaki T, Suda T. Angiopoietin-related growth factor (AGF), a member of the angiopoietin-
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Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events
Current Opinion in Lipidology, 2010Angiopoietin-like proteins (Angptls) comprise a family of secreted glycoproteins with high homology to angiopoietins which are important regulators of angiogenesis. Angptl3 and Angptl4 inhibit lipoprotein lipase in mice. This article reviews recent human studies on Angptls and their effects on lipoprotein profiles and cardiovascular disease.Population ...
Takashi, Miida, Satoshi, Hirayama
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Structure and Function of Angiopoietin-like Protein 3 (ANGPTL3) in Atherosclerosis
Current Medicinal Chemistry, 2020Background: Angiopoietin-Like Proteins (ANGPTLs) are structurally related to the angiopoietins. A total of eight ANGPTLs (from ANGPTL1 to ANGPTL8) have been identified so far. Most ANGPTLs possess multibiological functions on lipid metabolism, atherosclerosis, and cancer.
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Inhibition of angiopoietin-like protein 3 as a target for managing hypertriglyceridemia
Current Opinion in Endocrinology, Diabetes & ObesityPurpose of review To summarize recent advances in therapeutic strategies targeting angiopoietin-like protein 3 (ANGPTL3), a central regulator of triglyceride and remnant lipoprotein metabolism, and to discuss the potential of emerging pharmacologic approaches
Pablo, Corral +2 more
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A tale of two angiopoietin-like proteins
Current Opinion in Lipidology, 2007openaire +2 more sources