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Egyptian Pharmaceutical Journal, 2023
Background Obesity has recently been identified as a risk factor for coronavirus disease-19. There is a significant correlation between obesity rates with metabolic syndrome and coronavirus disease-19 in children worldwide. Owing to the high expression in adipose tissue, angiopoietin-like protein 5 (ANGPTL5) might be assumed to
Mai S. ElShiekh +7 more
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Background Obesity has recently been identified as a risk factor for coronavirus disease-19. There is a significant correlation between obesity rates with metabolic syndrome and coronavirus disease-19 in children worldwide. Owing to the high expression in adipose tissue, angiopoietin-like protein 5 (ANGPTL5) might be assumed to
Mai S. ElShiekh +7 more
openaire +1 more source
The Role of Angiopoietin-Like Proteins in Angiogenesis and Metabolism
Trends in Cardiovascular Medicine, 2008Recently, a family of proteins structurally similar to the angiogenic regulating factors angiopoietins was identified and designated "angiopoietin-like proteins" (Angptls). Encoded by seven genes, Angptls 1 to 7 all possess an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, both characteristic of angiopoietins.
Tai Hato, Yuichi Oike, Mitsuhisa Tabata
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Angiopoietin-Related/Angiopoietin-Like Proteins Regulate Angiogenesis
International Journal of Hematology, 2004A general understanding of the molecular mechanisms underlying angiogenesis is emerging from the analysis of targeted mutations in vasculature-related genes. These analyses reveal that angiopoietin signaling through the TIE2 receptor is involved in regulating angiogenesis.
Toshio Suda
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Angiopoietin-like proteins and postprandial partitioning of fatty acids
Current Opinion in Lipidology, 2021Purpose of review Over the last two decades, evolving discoveries around angiopoietin-like (ANGPTL) proteins, particularly ANGPTL3, ANGPTL4, and ANGPTL8, have generated significant interest in understanding their roles in fatty acid (FA) metabolism.
Nicole M, DiDonna +2 more
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The angiopoietin-like protein 3
Current Opinion in Lipidology, 2013Cumulating evidence are revealing roles of angiopoietin-like proteins (ANGPTLs) in lipid, glucose, and energy metabolism. In this review, we discuss the recent developments in understanding the specific role in metabolic processes of the liver-derived ANGPTL3.Several groups have reported clinical and metabolic characterization of individuals with loss ...
ARCA, Marcello +2 more
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The role of angiopoietin-like protein 2 in pathogenesis of dermatomyositis
Biochemical and Biophysical Research Communications, 2012Dermatomyositis (DM) is an autoimmune disease marked by chronic inflammation of skin and muscle tissues and characterized clinically by proximal muscle weakness and skin eruption, including heliotrope rash, and Gottron's sign. Treatment with a non-specific immunosuppressive agent or anti-inflammatory corticosteroids is beneficial, although some ...
Aki, Ogata +10 more
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Familial combined hypolipidemia: angiopoietin-like protein-3 deficiency
Current Opinion in Lipidology, 2020Purpose of review Angiopoietin-like protein-3 (ANGPTL3) is emerging as a key player in lipoprotein transport with an expanding role on fatty acid and glucose metabolism. Its deficiency is associated with a favorable metabolic profile.
Arca M., D'Erasmo L., Minicocci I.
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Angiopoietin-like 3: An important protein in regulating lipoprotein levels
Best Practice & Research Clinical Endocrinology & Metabolism, 2023ANGPTL3 has emerged as a therapeutic target whose inhibition results in profound reductions of plasma lipids, including atherogenic triglyceride-rich lipoproteins and low-density lipoprotein cholesterol. The identification of ANGPTL3 deficiency as a cause of familial combined hypolipidemia in humans hastened the development of anti-ANGPTL3 therapeutic ...
Kendall H, Burks +3 more
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Response of Angiopoietin-like Proteins 3 and 4 to Hemodialysis
The International Journal of Artificial Organs, 2014Background/Aim Patients on chronic hemodialysis (cHD) have decreased activity of lipoprotein lipase (LPL). Angiopoietin-like proteins (ANGPTL) 3 and 4 have been shown to inactivate LPL. The aim of this study was to investigate the levels of the ANGPTLs in plasma of cHD-patients and to evaluate if cHD may alter ...
Dana, Mahmood +4 more
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Modulation of plasma TG lipolysis by Angiopoietin-like proteins and GPIHBP1
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2010There is evidence that elevated plasma triglycerides (TG) serve as an independent risk factor for coronary heart disease. Plasma TG levels are determined by the balance between the rate of production of chylomicrons and VLDL in intestine and liver, respectively, and their rate of clearance in peripheral tissues.
Laeticia Lichtenstein, Sander Kersten
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