Results 191 to 200 of about 164,168 (220)
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Angiopoietins and Angiopoietin-Like Proteins in Angiogenesis
Endothelium: Journal of Endothelial Cell Research, 2006Vascular network formation requires several endothelial cell growth factors. These factors have a potent angiogenic effect, and their precise coordination is essential for vascular development. Among them, angiopoietins function through the Tie2 receptor, whose signaling is critical to regulate vascular stabilization and remodeling.
Tohru Morisada +2 more
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Angiopoietin-like proteins in multiple sclerosis
Journal of Neuroimmunology, 2019Angiopoietin-like proteins (ANGPTLs) are a group of proteins with functions in lipid metabolism, angiogenesis, and inflammation. Here, we investigated their involvement in multiple sclerosis (MS) progression and response to treatment in 100 MS patients and 77 healthy controls. ANGPTLs significantly associated with MS progression and response to therapy.
Rabeah Al-Temaimi +2 more
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Egyptian Pharmaceutical Journal, 2023
Background Obesity has recently been identified as a risk factor for coronavirus disease-19. There is a significant correlation between obesity rates with metabolic syndrome and coronavirus disease-19 in children worldwide. Owing to the high expression in adipose tissue, angiopoietin-like protein 5 (ANGPTL5) might be assumed to
Mai S. ElShiekh +7 more
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Background Obesity has recently been identified as a risk factor for coronavirus disease-19. There is a significant correlation between obesity rates with metabolic syndrome and coronavirus disease-19 in children worldwide. Owing to the high expression in adipose tissue, angiopoietin-like protein 5 (ANGPTL5) might be assumed to
Mai S. ElShiekh +7 more
openaire +1 more source
The Role of Angiopoietin-Like Proteins in Angiogenesis and Metabolism
Trends in Cardiovascular Medicine, 2008Recently, a family of proteins structurally similar to the angiogenic regulating factors angiopoietins was identified and designated "angiopoietin-like proteins" (Angptls). Encoded by seven genes, Angptls 1 to 7 all possess an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain, both characteristic of angiopoietins.
Tai Hato +2 more
exaly +3 more sources
Angiopoietin-like proteins and postprandial partitioning of fatty acids
Current Opinion in Lipidology, 2021Purpose of review Over the last two decades, evolving discoveries around angiopoietin-like (ANGPTL) proteins, particularly ANGPTL3, ANGPTL4, and ANGPTL8, have generated significant interest in understanding their roles in fatty acid (FA) metabolism.
Nicole M, DiDonna +2 more
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Angiopoietin-Related/Angiopoietin-Like Proteins Regulate Angiogenesis
International Journal of Hematology, 2004A general understanding of the molecular mechanisms underlying angiogenesis is emerging from the analysis of targeted mutations in vasculature-related genes. These analyses reveal that angiopoietin signaling through the TIE2 receptor is involved in regulating angiogenesis.
Yuichi Oike, Toshio Suda, Oike Yuichi
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The angiopoietin-like protein 3
Current Opinion in Lipidology, 2013Cumulating evidence are revealing roles of angiopoietin-like proteins (ANGPTLs) in lipid, glucose, and energy metabolism. In this review, we discuss the recent developments in understanding the specific role in metabolic processes of the liver-derived ANGPTL3.Several groups have reported clinical and metabolic characterization of individuals with loss ...
ARCA, Marcello +2 more
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Triglyceride metabolism and angiopoietin-like proteins in lipoprotein lipase regulation
Clinica Chimica Acta, 2020Hypertriglyceridemia is a risk factor for a series of diseases, such as cardiovascular disease (CVD), diabetes and nonalcoholic fatty liver disease (NAFLD). Angiopoietin-like proteins (ANGPTLs) family, especially ANGPTL3, ANGPTL4 and ANGPTL8, which regulate lipoprotein lipase (LPL) activity, play pivotal roles in triglyceride (TG) metabolism and ...
Suyun Li, Wei Xie
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Familial combined hypolipidemia: angiopoietin-like protein-3 deficiency
Current Opinion in Lipidology, 2020Purpose of review Angiopoietin-like protein-3 (ANGPTL3) is emerging as a key player in lipoprotein transport with an expanding role on fatty acid and glucose metabolism. Its deficiency is associated with a favorable metabolic profile.
Arca M., D'Erasmo L., Minicocci I.
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Angiopoietin-like 3: An important protein in regulating lipoprotein levels
Best Practice & Research Clinical Endocrinology & Metabolism, 2023ANGPTL3 has emerged as a therapeutic target whose inhibition results in profound reductions of plasma lipids, including atherogenic triglyceride-rich lipoproteins and low-density lipoprotein cholesterol. The identification of ANGPTL3 deficiency as a cause of familial combined hypolipidemia in humans hastened the development of anti-ANGPTL3 therapeutic ...
Kendall H, Burks +3 more
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