Results 31 to 40 of about 57,083 (310)

Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance

Investigative Opthalmology & Visual Science, 2022
Defects in the iridocorneal angle tissues, including the trabecular meshwork (TM) and Schlemm's canal (SC), impair aqueous humor flow and increase the intraocular pressure (IOP), eventually resulting in glaucoma. Activation of endothelial tyrosine kinase receptor Tie2 by angiopoietin-1 (Angpt1) has been demonstrated to be essential for SC formation ...
Kapiainen, E. (Emmi), Elamaa, H. (Harri), Miinalainen, I. (Ilkka), Izzi, V. (Valerio), Eklund, L. (Lauri)   +4 more
openaire   +3 more sources

Vasculotide reduces endothelial permeability and tumor cell extravasation in the absence of binding to or agonistic activation of Tie2

EMBO Molecular Medicine, 2015
Angiopoietin‐1 (Ang1) activation of Tie2 receptors on endothelial cells (ECs) reduces adhesion by tumor cells (TCs) and limits junctional permeability to TC diapedesis. We hypothesized that systemic therapy with Vasculotide (VT)—a purported Ang1 mimetic,
Florence TH Wu, Christina R Lee, Elena Bogdanovic, Aaron Prodeus, Jean Gariépy, Robert S Kerbel   +5 more
doaj   +1 more source

Serum Angiopoietin-1 and -2 and VEGF are associated with severe disease in vivax malaria

Journal of Vector Borne Diseases, 2020
Background & objectives: Malaria continues to be a significant public health problem in tropical countries including India; however, there are limited tools to predict occurrence of severe disease due to malaria.
Srinivas H Gowda, Hiren Anghan, Hridesh Mishra, Kunzang Chosdol, Manasvini Bhatt, Vinod Kumar, Piyush Ranjan, Praveen Aggarwal, Naveet Wig, Manish Soneja   +9 more
doaj   +1 more source

Angiogenesis, Lymphangiogenesis, and Inflammation in Chronic Obstructive Pulmonary Disease (COPD): Few Certainties and Many Outstanding Questions

Cells, 2022
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation, predominantly affecting the lung parenchyma and peripheral airways, that results in progressive and irreversible airflow obstruction.
Remo Poto, Stefania Loffredo, Francesco Palestra, Gianni Marone, Vincenzo Patella, Gilda Varricchi   +5 more
doaj   +1 more source

The Interplay between Angiopoietin-Like Proteins and Adipose Tissue: Another Piece of the Relationship between Adiposopathy and Cardiometabolic Diseases?

International Journal of Molecular Sciences, 2021
Angiopoietin-like proteins, namely ANGPTL3-4-8, are known as regulators of lipid metabolism. However, recent evidence points towards their involvement in the regulation of adipose tissue function.
Simone Bini, L. D'Erasmo, A. Di Costanzo, I. Minicocci, V. Pecce, M. Arca   +5 more
semanticscholar   +1 more source

Pro-angiogenic Activity Discriminates Human Adipose-Derived Stromal Cells From Retinal Pericytes: Considerations for Cell-Based Therapy of Diabetic Retinopathy

Frontiers in Cell and Developmental Biology, 2020
Diabetic retinopathy (DR) is a frequent diabetes-associated complication. Pericyte dropout can cause increased vascular permeability and contribute to vascular occlusion.
Heiner Kremer, Heiner Kremer, Julian Gebauer, Julian Gebauer, Susanne Elvers-Hornung, Susanne Elvers-Hornung, Stefanie Uhlig, Stefanie Uhlig, Stefanie Uhlig, Hans-Peter Hammes, Elena Beltramo, Lothar Steeb, Martin C. Harmsen, Carsten Sticht, Harald Klueter, Harald Klueter, Harald Klueter, Karen Bieback, Karen Bieback, Karen Bieback, Karen Bieback, Karen Bieback, Agnese Fiori, Agnese Fiori, Agnese Fiori   +24 more
doaj   +1 more source

Simultaneous Inhibition of Angiopoietin-2 and Vascular Endothelial Growth Factor-A with Faricimab in Diabetic Macular Edema: BOULEVARD Phase 2 Randomized Trial.

Ophthalmology (Rochester, Minn.), 2019
PURPOSE The phase 2 BOULEVARD trial compared safety and efficacy of faricimab, a novel bispecific antibody targeting angiopoietin-2 and vascular endothelial growth factor-A (VEGF-A), with ranibizumab in patients with diabetic macular edema (DME ...
J. Sahni, Sunil S. Patel, P. Dugel, A. Khanani, Chirag Jhaveri, C. Wykoff, Vrinda S. Hershberger, M. Pauly-Evers, S. Sadikhov, P. Szczęsny, D. Schwab, E. Nogoceke, A. Osborne, R. Weikert, S. Fauser   +14 more
semanticscholar   +1 more source

sj-docx-1-vrd-10.1177_24741264221126061 – Supplemental material for Intravitreal Nesvacumab (Anti-Angiopoietin-2) Plus Aflibercept in Neovascular AMD: Phase 2 ONYX Randomized Trial

, 2022
Supplemental material, sj-docx-1-vrd-10.1177_24741264221126061 for Intravitreal Nesvacumab (Anti-Angiopoietin-2) Plus Aflibercept in Neovascular AMD: Phase 2 ONYX Randomized Trial by Jeffrey S. Heier, Allen C. Ho, David S. Boyer, Karl Csaky, Robert Vitti,
Friedrich Asmus (14327961), Lorah Perlee (14327955), Robert Vitti (14327952), Karl Csaky (2686657), Allen C. Ho (13152645), Karen W. Chu (14327958), Sergio Leal (9140146), Oliver Zeitz (71487), Thomas Schmelter (796965), Yenchieh Cheng (14327964), Jeffrey S. Heier (14327946), David S. Boyer (14327949), David M. Brown (475802)   +12 more
core   +1 more source

Engineering Novel Angiopoietin Receptor Ligands

, 2011
Angiopoietin-1 is a multimeric glycoprotein which signals through the vascular endothelial Tie2 receptor to protect against inflammation and leakage, an effect antagonised by the selectively upregulated antagonist angiopoietin-2. In many pathologies this
Andrew James Moss (7659908)
core   +6 more sources

Alteration of Angiogenic Gene Expression in Heart, Muscle and Adipose Tissue by Exercise [PDF]

운동과학, 2018
PURPOSE Exercise is one of the strongest stimuli for the induction of angiogenesis that is defined as a formation of new blood vessel. However, underlying mechanism of exercise-induced angiogenesis is not fully uncovered.
Hyuek Jong Lee
doaj   +1 more source