Results 11 to 20 of about 57,083 (310)

Normalization of the serum angiopoietin-1 to angiopoietin-2 ratio reflects response in refractory/resistant multiple myeloma patients treated with bortezomib

Haematologica, 2008
Neoangiogenesis is involved in the pathophysiology of multiple myeloma and angiopoietins possibly contribute to myeloma-induced neovascularization. Bortezomib’s antineoplastic potential includes an anti-angiogenic effect.
Konstantinos Anargyrou, Evangelos Terpos, Theodoros P. Vassilakopoulos, Anastasia Pouli, Sotirios Sachanas, Tatiana Tzenou, Stavroula Masouridis, Dimitrios Christoulas, Maria K. Angelopoulou, Evangelia M. Dimitriadou, Christina Kalpadakis, Konstantinos Tsionos, Panayiotis Panayiotidis, Meletios A. Dimopoulos, Gerassimos A. Pangalis, Marie-Christine Kyrtsonis   +15 more
doaj   +3 more sources

Angiopoietin-2 [PDF]

Definitions, 2020
Angiopoietin-2 (496 kDa) is encoded by the human ANGPT2 gene. This protein plays a role in the regulation of endothelial cell apoptosis.

semanticscholar   +2 more sources

Serum Angiopoietin-1/Angiopoietin-2 at 16-18 Weeks of Gestation to Predict Preeclampsia [PDF]

, 2021
Objective: To determine whether serum angiopoietin-1/angiopoietin-2 ratio can predict preeclampsia in women at 16–18 weeks of gestation, or not. Material and Methods: This was a prospective observational study that was conducted in pregnant women with ...
Ruangsak Lertkhachonsuk, Patau Tanbirojn, Vorapong Phupong   +2 more
core   +1 more source

Angiopoietin-2 outperforms other endothelial biomarkers associated with severe acute kidney injury in patients with severe sepsis and respiratory failure

Critical Care, 2021
Endothelial dysfunction and injury is a major pathophysiologic feature of sepsis. Sepsis is also the most frequent cause of acute kidney injury (AKI) in critically ill patients.
Wen-Kuang Yu, J. B. McNeil, N. Wickersham, C. Shaver, J. Bastarache, L. Ware   +5 more
semanticscholar   +1 more source

Biological characterization of angiopoietin‐3 and angiopoietin‐4

The FASEB Journal, 2004
ABSTRACT The angiopoietin (Ang) family of growth factors includes Ang1, Ang2, Ang3, and Ang4, all of which bind to the endothelial receptor tyrosine kinase Tie2. Ang3 (mouse) and Ang4 (human) are interspecies orthologs.
Lee, HJ, Cho, CH, Hwang, SJ, Choi, HH, Kim, KT, Ahn, SY, Kim, JH, Oh, JL, Lee, GM Lee, Gyun-Min, Koh, GY Koh, Gou Young   +9 more
  +8 more sources

Dynamic angiopoietin-2 assessment predicts survival and chronic course in hospitalized patients with COVID-19

Blood Advances, 2021
This study examined the association between dynamic angiopoietin-2 assessment and COVID-19 short- and long-term clinical course. We included consecutive hospitalized patients from 1 February to 31 May 2020 with laboratory-confirmed COVID-19 from 2 ...
E. Villa, R. Critelli, Simone Lasagni, A. Melegari, A. Curatolo, C. Celsa, D. Romagnoli, G. Melegari, A. Pivetti, Lorenza Di Marco, F. Casari, D. Arioli, F. Turrini, V. Zuccaro, I. Cassaniti, M. Riefolo, Elena De Santis, V. Bernabucci, M. Bianchini, B. Lei, N. De Maria, L. Carulli, F. Schepis, C. Gozzi, Silvio Malaguti, M. Del Buono, L. Brugioni, P. Torricelli, T. Trenti, G. Pinelli, E. Bertellini, R. Bruno, C. Cammà, D, Antonia Errico   +34 more
semanticscholar   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation—A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients

Biomedicines, 2022
Hypercoagulation and endothelial dysfunction play central roles in severe forms of COVID-19 infections, but the molecular mechanisms involved are unclear.
M. Hultström, K. Fromell, A. Larsson, B. Persson, B. Nilsson, S. Quaggin, C. Betsholtz, R. Frithiof, M. Lipcsey, M. Jeansson   +9 more
semanticscholar   +1 more source

Anti-angiogenic Targets: Angiopoietin and Angiopoietin Receptors [PDF]

, 2017
Tumor blood vessel formation (angiogenesis) is essential for tumor growth and metastasis. Two main endothelial ligand–receptor pathways regulating angiogenesis are vascular endothelial growth factor (VEGF) receptor and angiopoietin-TIE receptor pathways.
Kiss, Elina A., Saharinen, Pipsa
openaire   +1 more source

Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. [PDF]

, 2013
We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angiopoietin-1 (Ang1), is required for early vessel destabilization during postischemic angiogenesis, when combined with vascular growth factors.
Di Qin (107446), Seungmin Lee (68256), Qin, Di, Christian Kupatt (402864), Rabea Hinkel, Trenkwalder, Teresa, Rabea Hinkel (402865), Deindl, Elisabeth, Chillo, Omary, Teresa Trenkwalder (402861), Seungmin Lee, Christian Kupatt, Omary Chillo, Lee, Seungmin, Omary Chillo (402862), Kupatt, Christian, Elisabeth Deindl (402863), Di Qin, Hinkel, Rabea, Teresa Trenkwalder, Elisabeth Deindl   +20 more
core   +2 more sources