Results 21 to 30 of about 57,083 (310)
Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice
Biomedicines, 2023 In Duchenne muscular dystrophy (DMD), angiogenesis appears to be attenuated. Local administration of angiopoietin 1 (Ang1) has been shown to reduce inflammation, ischemia, and fibrosis in DMD mice.
Yiming Lin +2 more
doaj +1 more source
Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology
Cells, 2019 Angiopoietins 1–4 (Ang1–4) represent an important family of growth factors, whose activities are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized are angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2).
R. Akwii +3 more
semanticscholar +1 more source
Cells, 2020 This review summarizes the latest findings in the literature of Angiopoietin-2 (Ang-2), Tyrosine-protein kinase receptor (Tie-2) complex, and faricimab along with their involvement for the treatment of retinal vascular diseases in various clinical trials.
Majid Khan +4 more
semanticscholar +1 more source
Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria [PDF]
, 2009 Background Severe and cerebral malaria are associated with endothelial activation. Angiopoietin-1 (ANG-1) and angiopoietin-2 (ANG-2) are major regulators of endothelial activation and integrity.
Liles W Conrad +21 more
core +1 more source
Microorganisms, 2023 The viral agent SARS-CoV-2 clearly affects several organ systems, including the cardiovascular system. Angiopoietins are involved in vascular integrity and angiogenesis.
Rachelle P. Mendoza +8 more
doaj +1 more source
Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. [PDF]
, 2009 BACKGROUND: Limited tools exist to identify which individuals infected with Plasmodium falciparum are at risk of developing serious complications such as cerebral malaria (CM). The objective of this study was to assess serum biomarkers that differentiate
Hawkes, Michael +38 more
core +1 more source
New molecular mediators in tumor angiogenesis [PDF]
, 2007 Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Jonas, Dietger +2 more
core +1 more source
Short-Term Outcomes of Intravitreal Faricimab Injection for Diabetic Macular Edema
Medicina, 2023 Background and Objectives: Faricimab is a novel bispecific antibody with Fab regions inhibiting both vascular endothelial growth factor-A and angiopoietin-2. Therefore, this study aimed to obtain short-term outcomes of intravitreal injection of faricimab
Sentaro Kusuhara +5 more
doaj +1 more source
Angiopoietin-2 induces angiogenesis via exosomes in human hepatocellular carcinoma
Cell Communication and Signaling, 2020 Hepatocellular carcinoma (HCC) is the most common primary liver cancer and is a highly vascularized solid tumor. Angiopoietin-2 (ANGPT2) has been described as an attractive target for antiangiogenic therapy.
Jiyan Xie +11 more
semanticscholar +1 more source
Angiopoietin-1/Angiopoietin-2 Ratio for Prediction of Preeclampsia [PDF]
American Journal of Hypertension, 2009 A number of different biophysical and biochemical markers have been proposed as predictors of preeclampsia. Factors involved in the angiogenic balance are suggested as candidate markers. The purpose of this prospective, longitudinal cohort study was to determine whether a ratio between Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) can be used to ...
Marie, Bolin +6 more
openaire +2 more sources