Results 101 to 110 of about 97,507,719 (246)

Real‐World Safety and Effectiveness of Icatibant in Patients With Hereditary Angioedema (HAE): Post‐Marketing Surveillance in Japan

The Journal of Dermatology, EarlyView.
ABSTRACT Hereditary angioedema (HAE) is a rare, autosomal dominant, life‐threatening disease characterized by recurrent attacks of swelling of the face, upper airway, gastrointestinal tract, limbs, and/or genitalia. Genetic mutations of the SERPING1 gene encoding the C1‐inhibitor (C1‐INH) plasma protein are associated with HAE‐C1INH.
Kumiko Hosono, Miyako Hoshino
wiley   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria

, 2012
Objective: To investigate the relationship among the angiopoietin–Tie-2 system, retinopathy, and mortality in children with cerebral malaria. Design: A case–control study of retinopathy-positive vs.
Hawkes, Michael, Molyneux, Malcolm E, Seydel, Karl B., Conroy, Andrea L., Glover, Simon J., Taylor, Terrie E., Kain, Kevin C., Erdman, Laura K.   +7 more
core   +1 more source

High angiopoietin-2 levels associate with arterial inflammation and long-term glucocorticoid requirement in polymyalgia rheumatica [PDF]

, 2019
OBJECTIVES: PMR frequently co-occurs with GCA. So far, a simple biomarker for detecting concomitant arterial inflammation in PMR patients is lacking. Furthermore, biomarkers predicting disease course in PMR are awaited.
Boots, Annemieke, Bijzet, Johan; id_orcid, Maria Sandovici, van Sleen, Yannick, Abdulahad, Wayel; id_orcid, Yannick van Sleen, Boots, Annemieke M. H., Brouwer, Elisabeth, Annemieke Boots, Wayel Abdulahad, van der Geest, Kornelis; id_orcid, Elisabeth Brouwer, Sandovici, Maria; id_orcid, van der Geest, Kornelis S. M.; id_orcid, Kornelis van der Geest, Abdulahad, Wayel H.; id_orcid, Johan Bijzet   +16 more
core   +1 more source

Real‐world incidence and clinical characteristics of intraocular inflammation following intravitreal faricimab therapy: A safety study

Acta Ophthalmologica, EarlyView.
Abstract Purpose To estimate the real‐world incidence of intraocular inflammation (IOI) following intravitreal faricimab injections at a large, highly specialized tertiary centre. Methods Single‐centre, retrospective cohort study with chart review using an electronic injection database and electronic medical records from November 2023 to August 2024 ...
Miklos Schneider, Leyla Turan, Farah Arif, Jakob Bjerager, Oliver Niels Klefter, Carsten Faber, Yousif Subhi, Javad Nouri Hajari   +7 more
wiley   +1 more source

Intravitreal faricimab in patients with nAMD: French data from the Fight Retinal Blindness! Registry

Acta Ophthalmologica, EarlyView.
Abstract Purpose To assess real‐world outcomes of intravitreal faricimab in French patients with neovascular age‐related macular degeneration (nAMD) previously treated with vascular endothelial growth factor (VEGF) inhibitors using data from the Fight Retinal Blindness! (FRB!) Registry.
Eloi Debourdeau, Déborah Harboun, Pierre‐Henry Gabrielle, Yohei Hashimoto, Chloe Chamard, Frederic Michon, Benjamin Wolff, Héloïse Torres‐Villaros, Audrey Giocanti‐Auregan, Mark Gillies, Catherine Creuzot–Garcher, Vincent Daien   +11 more
wiley   +1 more source

Exploring some pro-inflammatory cytokines and adipokines as novel biomarkers in polycystic ovary syndrome

Italian Journal of Medicine
Non-communicable diseases are more likely to affect women with polycystic ovarian syndrome (PCOS), in particular, mostly ascribed to the existence of low-grade chronic inflammation brought on by adipokines and proinflammatory cytokines.
Dlvin Akif Mustafa, Parween Abdulsamad Ismail   +1 more
doaj   +1 more source

Validation of a human angiopoietin-2 enzyme linked immunosorbent assay kit for measurement of canine angiopoietin-2 concentrations in plasma and supernatant of primary canine aortic endothelial cell cultures

, 2018
Objective – To assess two human ELISA kits for measurement of angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) in canine plasma and to evaluate the effect of sepsis on plasma Ang-2 concentrations. To isolate and culture primary canine aortic endothelial
Wyder, Marianne, Giger, Urs, Konig, Maya L, König, Maya L., Schuller, Simone, Marti, Eliane, Lettry, Sophie C., Lettry, Sophie C, Mirkovitch, Jelena, Lettry, Sophie, König, Maya Laura, Marti, Eliane Isabelle   +11 more
core   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Type XII RTKs: TIE family of angiopoietin receptors in GtoPdb v.2025.3 [PDF]

The TIE family were initially associated with formation of blood vessels (angiogenesis). Endogenous ligands are angiopoietin-1, angiopoietin-2, and angiopoietin-4. angiopoietin-2 appears to act as an endogenous antagonist of angiopoietin-1 function, thus
Peach, Chloe J.
core   +1 more source