Results 41 to 50 of about 190,682 (162)

Soluble angiotensin-converting enzyme 2 association with lipid metabolism

Frontiers in Medicine, 2022
Increased expression of angiotensin-converting enzyme 2 (ACE2) is one of the likely explanations for disease severity in patients with coronavirus disease 2019 (COVID-19). In this study, we aimed to test whether soluble ACE2 (sACE2) levels are correlated
Izumi Nagatomo, Kaori Nakanishi, Ryohei Yamamoto, Seiko Ide, Chisaki Ishibashi, Toshiki Moriyama, Keiko Yamauchi-Takihara   +6 more
doaj   +1 more source

Circulating Activities of Angiotensin-Converting Enzyme, Its Homolog, Angiotensin-Converting Enzyme 2, and Neprilysin in a Family Study [PDF]

Hypertension, 2006
The renin–angiotensin system is a key regulator of blood pressure (BP), with inhibitors of angiotensin-converting enzyme (ACE) used clinically to treat hypertension and other cardiovascular conditions. ACE2 is a newly identified member of this system, which converts angiotensin II to angiotensin (1-7), and of which the occurrence in plasma has not been
Rice, Gillian I., Jones, Amy L., Grant, Peter J., Carter, Angela M., Turner, Anthony J., Hooper, Nigel M.; id_orcid 0000-0002-5811-3484   +5 more
openaire   +2 more sources

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors

Frontiers in Pharmacology, 2015
Angiotensin converting enzyme 2 (ACE2) is a zinc carboxypeptidase involved in the renin angiotensin system (RAS) and inactivates the potent vasopressive peptide angiotensin II (Ang II) by removing the C-terminal phenylalanine residue to yield Ang1-7 ...
Daniel eClayton, Iresha eHanchapola, Walter Glen Thomas, Robert eWiddop, Alexander Ian Smith, Patrick ePerlmutter, Marie-Isabel eAguilar   +6 more
doaj   +1 more source

2019 novel-coronavirus: Cardiovascular insights about risk factors, myocardial injury, therapy and clinical implications

Chronic Diseases and Translational Medicine, 2020
From December 31st, 2019, a novel highly pathogenic coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide, reaching at present the dimension of a pandemic.
Luigi Cappannoli, Roberto Scacciavillani, Giulia Iannaccone, Gianluca Anastasia, Federico Di Giusto, Valentina Loria, Nadia Aspromonte   +6 more
doaj   +1 more source

Expression of angiotensin-converting enzyme and angiotensin-converting enzyme 2 in patients with chronic heart failure [PDF]

Heart, 2011
Background It has been reported that angiotensin converting enzyme 2 (ACE2) is an endogenous counterregulator of the rennin angiotensin aldosterone system (RAAS). However, the role of ACE2 in the development of human heart failure is not well established. Methods and
Jiang Wang, Nan Li, Ai-min Li, Rong Song, Feng Gao, Zhao-Hua Geng   +5 more
openaire   +2 more sources

Neuromodulation by selective angiotensin-converting enzyme 2 inhibitors

Neuroscience, 2022
Here, neuromodulatory effects of selective angiotensin-converting enzyme 2 (ACE2) inhibitors were investigated. Two different types of small molecule ligands for ACE2 inhibition were selected using chemical genetic approach, they were synthesized using developed chemical method and tested using presynaptic rat brain nerve terminals (synaptosomes).
Natalia, Pozdnyakova, Natalia, Krisanova, Artem, Pastukhov, Alla, Tarasenko, Marina, Dudarenko, Anton, Chernykh, Alexander, Pashenko, Sergey, Ryabukhin, Ganna, Tolstanova, Dmitriy, Volochnyuk, Tatiana, Borisova   +10 more
openaire   +2 more sources

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with COVID-19: General Considerations and Clinical Implications

Journal of Cardiac Arrhythmias, 2020
Initially reported in China at the end of 2019, the coronavirus pandemic has now reached an international scale with more than1.5 million cases worldwide and more than 80,000 deaths by April 8th of this year.
Neiberg de Alcantara Lima, Pedro Yuri Paiva Lima, Ricardo Lessa de Castro Junior, Eric Martin Sieloff, Stela Maria Vitorino Sampaio   +4 more
doaj   +1 more source

Angiotensin-Converting Enzyme 2 Gene Expression in Breast Tissue

European Journal of Breast Health, 2021
Objective:Binding to angiotensin-converting enzyme 2 (ACE2) receptor is a critical step for severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) to mediate its entry into target cells. ACE2 is expressed in many human tissues, including the lungs.
Sammy Al-Benna
doaj   +1 more source

ACE gene dosage determines additional autonomic dysfunction and increases renal angiotensin II levels in diabetic mice

Clinics, 2018
OBJECTIVES: The present study aimed to investigate cardiovascular autonomic modulation and angiotensin II (Ang II) activity in diabetic mice that were genetically engineered to harbor two or three copies of the angiotensin-converting enzyme gene ...
Oscar Albuquerque de Moraes, Karin Flues, Kátia Bilhar Scapini, Cristiano Mostarda, Fabiana de Sant’Anna Evangelista, Bruno Rodrigues, Daniela Ravizzoni Dartora, Patricia Fiorino, Kátia De Angelis, Maria Cláudia Irigoyen   +9 more
doaj   +1 more source

The Role of Glutathione in Protecting against the Severe Inflammatory Response Triggered by COVID-19

Antioxidants, 2020
The novel COVID-19 pandemic is affecting the world’s population differently: mostly in the presence of conditions such as aging, diabetes and hypertension the virus triggers a lethal cytokine storm and patients die from acute respiratory distress ...
Francesca Silvagno, Annamaria Vernone, Gian Piero Pescarmona   +2 more
doaj   +1 more source