Results 41 to 50 of about 206,964 (305)

Angiotensin-converting enzyme 2: virus accomplice or host defender?

Journal of Bio-X Research, 2023
Objective:. Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to social disruptions, mainly because we know too little about SARS-CoV-2. Methods and Results:.
Jiyan Wang, Hongkai Chang, Yaya Qiao, Huanran Sun, Xichuan Li, Shuofeng Yuan, Shuai Zhang, Changliang Shan   +7 more
doaj   +1 more source

The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans [PDF]

, 2012
Aims - Inhibition of neutral endopeptidases (NEP) results in a beneficial increase in plasma concentrations of natriuretic peptides such as ANP.
Johnston, F., Maguire, J.J., Maguire, Janet J., Seed, Alison, Hanka J. de Voogd, Essers, H., Janet J. Maguire, Kuc, R.E., de Voogd, H.J., Kuc, Rhoda E., Seed, A., McMurray, J.J.V., Davenport, Anthony P., Hillier, Christopher, Rhoda E. Kuc, Anthony P. Davenport, Hillier, C., Hans Essers, Davenport, A.P., Alison Seed, Johnston, Fiona, John McMurray, Christopher Hillier, McMurray, John, Fiona Johnston, Essers, Hans, de Voogd, Hanka J.   +26 more
core   +1 more source

Could Anti‐Hypertensive Drug Therapy Affect the Clinical Prognosis of Hypertensive Patients With COVID‐19 Infection? Data From Centers of Southern Italy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
BACKGROUND Coronavirus disease 2019 (COVID‐19) is the cause of a pandemic disease, with severe acute respiratory syndrome by binding target epithelial lung cells through angiotensin‐converting enzyme 2 in humans.
Celestino Sardu, Paolo Maggi, Vincenzo Messina, Pasquale Iuliano, Antonio Sardu, Vincenzo Iovinella, Giuseppe Paolisso, Raffaele Marfella   +7 more
doaj   +1 more source

Angiotensin-converting enzyme 2 in lung diseases

Current Opinion in Pharmacology, 2006
The renin-angiotensin system (RAS) plays a key role in maintaining blood pressure homeostasis, as well as fluid and salt balance. Angiotensin II, a key effector peptide of the system, causes vasoconstriction and exerts multiple biological functions. Angiotensin-converting enzyme (ACE) plays a central role in generating angiotensin II from angiotensin I,
Kuba, Keiji, Imai, Yumiko, Penninger, Josef M   +2 more
openaire   +2 more sources

Alterations in Circulatory and Renal Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 in Fetal Programmed Hypertension [PDF]

Hypertension, 2009
Antenatal betamethasone treatment is a widely accepted therapy to accelerate lung development and improve survival in preterm infants. However, there are reports that infants who receive antenatal glucocorticoids exhibit higher systolic blood pressure in their early adolescent years.
Hossam A, Shaltout, Jorge P, Figueroa, James C, Rose, Debra I, Diz, Mark C, Chappell   +4 more
openaire   +2 more sources

Murine Recombinant Angiotensin-Converting Enzyme 2 [PDF]

Hypertension, 2012
A newly produced murine recombinant angiotensin (Ang)-converting enzyme 2 (ACE2) was characterized in vivo and in vitro. The effects of available ACE2 inhibitors (MLN-4760 and 2 conformational variants of DX600, linear and cyclic) were also examined.
Minghao, Ye, Jan, Wysocki, Francisco R, Gonzalez-Pacheco, Mahmoud, Salem, Karla, Evora, Laura, Garcia-Halpin, Marko, Poglitsch, Manfred, Schuster, Daniel, Batlle   +8 more
openaire   +2 more sources

Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2and cell proliferationviaGαq-mediated mechanism [PDF]

, 2014
Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Cai, X, Jiang, Y, Karteris, E, Bai, B, Chen, J, Karteris, Emmanouil, Bai, Bo, Jiang, Yunlu, Cai, Xin, Chen, Jing   +9 more
core   +1 more source

Soluble angiotensin-converting enzyme 2 association with lipid metabolism

Frontiers in Medicine, 2022
Increased expression of angiotensin-converting enzyme 2 (ACE2) is one of the likely explanations for disease severity in patients with coronavirus disease 2019 (COVID-19). In this study, we aimed to test whether soluble ACE2 (sACE2) levels are correlated
Izumi Nagatomo, Kaori Nakanishi, Ryohei Yamamoto, Seiko Ide, Chisaki Ishibashi, Toshiki Moriyama, Keiko Yamauchi-Takihara   +6 more
doaj   +1 more source

Circulating Activities of Angiotensin-Converting Enzyme, Its Homolog, Angiotensin-Converting Enzyme 2, and Neprilysin in a Family Study [PDF]

Hypertension, 2006
The renin–angiotensin system is a key regulator of blood pressure (BP), with inhibitors of angiotensin-converting enzyme (ACE) used clinically to treat hypertension and other cardiovascular conditions. ACE2 is a newly identified member of this system, which converts angiotensin II to angiotensin (1-7), and of which the occurrence in plasma has not been
Rice, Gillian I., Jones, Amy L., Grant, Peter J., Carter, Angela M., Turner, Anthony J., Hooper, Nigel M.; id_orcid 0000-0002-5811-3484   +5 more
openaire   +2 more sources

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors

Frontiers in Pharmacology, 2015
Angiotensin converting enzyme 2 (ACE2) is a zinc carboxypeptidase involved in the renin angiotensin system (RAS) and inactivates the potent vasopressive peptide angiotensin II (Ang II) by removing the C-terminal phenylalanine residue to yield Ang1-7 ...
Daniel eClayton, Iresha eHanchapola, Walter Glen Thomas, Robert eWiddop, Alexander Ian Smith, Patrick ePerlmutter, Marie-Isabel eAguilar   +6 more
doaj   +1 more source