Results 31 to 40 of about 206,964 (305)

Stimulation of Angiotensin Converting Enzyme 2: A Novel Treatment Strategy for Diabetic Nephropathy

Frontiers in Physiology, 2022
Despite current therapies for diabetic nephropathy, many patients continue to progress to end-stage renal disease requiring renal replacement therapy.
Haru Nomura, Sanjaya Kuruppu, Niwanthi W. Rajapakse   +2 more
doaj   +1 more source

Angiotensin-converting enzyme insertion/deletion polymorphism does not influence the restenosis rate after coronary stent implantation [PDF]

, 2002
Background. Experimental studies have shown an activation of the angiotensin-converting enzyme (ACE) system as a response to endothelial injury. Recent publications have elucidated the hypothesis that the ACE gene polymorphism may influence the level of ...
Hausmann, Dirk, Koschyk, Dietmar H., Grip, Lars, Ferrari, Markus, de Jaegere, Peter, Rieber, Johannes, Figulla, Hans R., Mudra, Harald, Schächinger, Volker, Rothman, Martin, Voudris, Vassilis   +10 more
core   +1 more source

Thymosin-α1 binds with ACE and downregulates the expression of ACE2 in human respiratory epithelia

Frontiers in Bioscience-Landmark, 2022
Background: Thymosin-α1 has been implicated into the treatment of novel respiratory virus Coronavirus Disease 2019 (COVID-19), but the underlying mechanisms are still disputable.
Yu-Hang Zhang, Wen-Yu Wang, Xiao-Cong Pang, Zhi Wang, Cheng-Zhuo Wang, Hang Zhou, Bo Zheng, Yi-Min Cui   +7 more
doaj   +1 more source

Angiotensin-Converting Enzyme 2 [PDF]

Hypertension, 2008
The first reports1,2 of the angiotensin-converting enzyme (ACE) homolog, ACE2, in mid-2000 came almost 50 years after the discovery of ACE and, remarkably, its existence had not been predicted from the known physiology of the renin-angiotensin system (RAS) at the time. There has since been an exponential growth in knowledge of ACE2 functions,3 spanning
openaire   +5 more sources

From gene to protein - experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension

Frontiers in Physiology, 2014
Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and the renin-angiotensin system (RAS) plays a major role in its pathogenesis.
Sheila K Patel, Elena eVelkoska, Melanie eFreeman, Bryan eWai, Terase F Lancefield, Louise M Burrell, Louise M Burrell, Louise M Burrell   +7 more
doaj   +1 more source

Correlation between plasma-soluble angiotensin-converting enzyme 2, anti- angiotensin-converting enzyme 2, and angiotensin-(1–7) in patients with chronic heart failure

Cardiology Plus, 2019
Background: Angiotensin-converting enzyme 2 (ACE2) is an ACE homolog that converts angiotensin II into angiotensin-(1–7) (Ang-[1–7]). Tumor necrosis factor α (TNF-α), interleukin-1 β, and interleukin-6 are plasma inflammatory cytokines that play a role ...
Yi Gu, Xiao-Hui Yang, Muhammad Nabeel Dookhun, Jian-Song Zhou, Si-Liang Xia, Hui Zhang, Xiao-Yi Qin, Yu-Qing Yang, Jia-Li Cao, Hua-Yi-Yang Zou, Xiao-Qian Xiao, Xin Zheng Lu   +11 more
doaj   +1 more source

Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade

Case Reports in Nephrology, 2020
The renin-angiotensin system plays a very critical role in hypertension, diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage.
Avantika Chenna, Venu Madhav Konala, Subhasish Bose, Sasmit Roy, Bhaskar Reddy Madhira, Vijay Gayam, Srikanth Naramala, Sreedhar Adapa   +7 more
doaj   +1 more source

Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Angiotensin-Converting Enzyme 2 Levels: A Comprehensive Analysis Based on Animal Studies

Frontiers in Pharmacology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the pathogen of coronavirus disease 2019 (COVID‐19), caused the outbreak escalated to pandemic. Reports suggested that near 1–3% of COVID‐19 cases have a fatal outcome.
Gábor Kriszta, Gábor Kriszta, Zsófia Kriszta, Zsófia Kriszta, Szilárd Váncsa, Szilárd Váncsa, Péter Jenő Hegyi, Levente Frim, Bálint Erőss, Péter Hegyi, Péter Hegyi, Gábor Pethő, Gábor Pethő, Erika Pintér   +13 more
doaj   +1 more source

A genome-wide search replicates evidence of a quantitative trait locus for circulating angiotensisn l-converting enzyme (ACE) unlinked to the ACE gene [PDF]

, 2008
Background: angiotensin I-converting enzyme (ACE) plays an important role in cardiovascular homeostasis. There is evidence from different ethnic groups that circulating ACE levels are influenced by a quantitative trait locus (QTL) at the ACE gene on ...
Amy Luke, Zhu, Xiaofeng, Xiaofeng Zhu, Terrence E Forrester, Forrester, Terrence E., Nourdine Bouzekri, Cooper, Richard S., Bouzekri Nourdine, Colin A McKenzie, McKenzie, Coiln A., Forrester Terrence E, Zhu Xiaofeng, McKenzie Colin A, Adeyemo, Adebowale A., Luke Amy, Bouzekri, Nourdine, Cooper Richard S, Richard S Cooper, Luke, Amy, Adebowale A Adeyemo, Adeyemo Adebowale A   +20 more
core   +1 more source

Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients

eLife, 2020
The discovery of angiotensin converting enzyme-2 (ACE-2) as the receptor for SARS- CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) has implicated the renin-angiotensin-aldosterone system in acute respiratory distress syndrome (ARDS) and ...
Gian Paolo Rossi, Viola Sanga, Matthias Barton   +2 more
doaj   +1 more source