Results 31 to 40 of about 190,682 (162)

From gene to protein - experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension

Frontiers in Physiology, 2014
Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and the renin-angiotensin system (RAS) plays a major role in its pathogenesis.
Sheila K Patel, Elena eVelkoska, Melanie eFreeman, Bryan eWai, Terase F Lancefield, Louise M Burrell, Louise M Burrell, Louise M Burrell   +7 more
doaj   +1 more source

Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade

Case Reports in Nephrology, 2020
The renin-angiotensin system plays a very critical role in hypertension, diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage.
Avantika Chenna, Venu Madhav Konala, Subhasish Bose, Sasmit Roy, Bhaskar Reddy Madhira, Vijay Gayam, Srikanth Naramala, Sreedhar Adapa   +7 more
doaj   +1 more source

Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Angiotensin-Converting Enzyme 2 Levels: A Comprehensive Analysis Based on Animal Studies

Frontiers in Pharmacology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the pathogen of coronavirus disease 2019 (COVID‐19), caused the outbreak escalated to pandemic. Reports suggested that near 1–3% of COVID‐19 cases have a fatal outcome.
Gábor Kriszta, Gábor Kriszta, Zsófia Kriszta, Zsófia Kriszta, Szilárd Váncsa, Szilárd Váncsa, Péter Jenő Hegyi, Levente Frim, Bálint Erőss, Péter Hegyi, Péter Hegyi, Gábor Pethő, Gábor Pethő, Erika Pintér   +13 more
doaj   +1 more source

Correlation between plasma-soluble angiotensin-converting enzyme 2, anti- angiotensin-converting enzyme 2, and angiotensin-(1–7) in patients with chronic heart failure

Cardiology Plus, 2019
Background: Angiotensin-converting enzyme 2 (ACE2) is an ACE homolog that converts angiotensin II into angiotensin-(1–7) (Ang-[1–7]). Tumor necrosis factor α (TNF-α), interleukin-1 β, and interleukin-6 are plasma inflammatory cytokines that play a role ...
Yi Gu, Xiao-Hui Yang, Muhammad Nabeel Dookhun, Jian-Song Zhou, Si-Liang Xia, Hui Zhang, Xiao-Yi Qin, Yu-Qing Yang, Jia-Li Cao, Hua-Yi-Yang Zou, Xiao-Qian Xiao, Xin Zheng Lu   +11 more
doaj   +1 more source

Angiotensin-converting enzyme 2: virus accomplice or host defender?

Journal of Bio-X Research, 2023
Objective:. Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to social disruptions, mainly because we know too little about SARS-CoV-2. Methods and Results:.
Jiyan Wang, Hongkai Chang, Yaya Qiao, Huanran Sun, Xichuan Li, Shuofeng Yuan, Shuai Zhang, Changliang Shan   +7 more
doaj   +1 more source

Could Anti‐Hypertensive Drug Therapy Affect the Clinical Prognosis of Hypertensive Patients With COVID‐19 Infection? Data From Centers of Southern Italy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
BACKGROUND Coronavirus disease 2019 (COVID‐19) is the cause of a pandemic disease, with severe acute respiratory syndrome by binding target epithelial lung cells through angiotensin‐converting enzyme 2 in humans.
Celestino Sardu, Paolo Maggi, Vincenzo Messina, Pasquale Iuliano, Antonio Sardu, Vincenzo Iovinella, Giuseppe Paolisso, Raffaele Marfella   +7 more
doaj   +1 more source

Alterations in Circulatory and Renal Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 in Fetal Programmed Hypertension [PDF]

Hypertension, 2009
Antenatal betamethasone treatment is a widely accepted therapy to accelerate lung development and improve survival in preterm infants. However, there are reports that infants who receive antenatal glucocorticoids exhibit higher systolic blood pressure in their early adolescent years.
Hossam A, Shaltout, Jorge P, Figueroa, James C, Rose, Debra I, Diz, Mark C, Chappell   +4 more
openaire   +2 more sources

Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients

eLife, 2020
The discovery of angiotensin converting enzyme-2 (ACE-2) as the receptor for SARS- CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) has implicated the renin-angiotensin-aldosterone system in acute respiratory distress syndrome (ARDS) and ...
Gian Paolo Rossi, Viola Sanga, Matthias Barton   +2 more
doaj   +1 more source

Angiotensin-converting enzyme 2 in lung diseases

Current Opinion in Pharmacology, 2006
The renin-angiotensin system (RAS) plays a key role in maintaining blood pressure homeostasis, as well as fluid and salt balance. Angiotensin II, a key effector peptide of the system, causes vasoconstriction and exerts multiple biological functions. Angiotensin-converting enzyme (ACE) plays a central role in generating angiotensin II from angiotensin I,
Kuba, Keiji, Imai, Yumiko, Penninger, Josef M   +2 more
openaire   +2 more sources

Murine Recombinant Angiotensin-Converting Enzyme 2 [PDF]

Hypertension, 2012
A newly produced murine recombinant angiotensin (Ang)-converting enzyme 2 (ACE2) was characterized in vivo and in vitro. The effects of available ACE2 inhibitors (MLN-4760 and 2 conformational variants of DX600, linear and cyclic) were also examined.
Minghao, Ye, Jan, Wysocki, Francisco R, Gonzalez-Pacheco, Mahmoud, Salem, Karla, Evora, Laura, Garcia-Halpin, Marko, Poglitsch, Manfred, Schuster, Daniel, Batlle   +8 more
openaire   +2 more sources