Results 11 to 20 of about 190,682 (162)

Angiotensin‐converting enzyme 2 and the kidney [PDF]

Experimental Physiology, 2008
Angiotensin‐converting enzyme (ACE) 2 is a homologue of ACE with enzymatic activity that seems to counterbalance the angiotensin II‐promoting effect of ACE. While ACE promotes angiotensin (Ang) II formation from Ang I, ACE2 degrades Ang II and Ang I.
Maria Jose, Soler, Jan, Wysocki, Daniel, Batlle   +2 more
openaire   +2 more sources

Angiotensin-Converting Enzyme Inhibitor / Angiotensin II Receptor Blocker in COVID-19: a Double-edged Sword or a Myth

Nepalese Medical Journal, 2020
Angiotensin-converting enzyme-2 receptor has been unearthed as a prime site of entry of Severe Acute Respiratory Syndrome Coronavirus 2 owing to its strong affinity towards spike protein of Severe Acute Respiratory Syndrome Coronavirus 2, resulting in ...
Kunal Bikram Shaha, Ashok Adhikari, Jung Rae Cho, Bimal Pandey, Yubaraj Sharma, Sajjad Safi   +5 more
doaj   +1 more source

Dietary Potassium Downregulates Angiotensin-I Converting Enzyme, Renin, and Angiotensin Converting Enzyme 2

Frontiers in Pharmacology, 2020
BackgroundThe importance of dietary potassium in health and disease has been underestimated compared with that placed on dietary sodium. Larger effort has been made on reduction of sodium intake and less on the adequate dietary potassium intake, although
Carlos P. Vio, Carlos P. Vio, Pedro Gallardo, Carlos Cespedes, Carlos Cespedes, Daniela Salas, Jessica Diaz-Elizondo, Natalia Mendez   +7 more
doaj   +1 more source

Angiotensin II and COVID-19. Secrets of interactions

Российский кардиологический журнал, 2020
The article describes current data on the relationship of renin-angiotensin system and related drugs with the risk of COVID-19 infection and its outcomes.
A. O. Konradi, A. O. Nedoshivin
doaj   +1 more source

Isolation of Bat Sarbecoviruses, Japan

Emerging Infectious Diseases, 2022
Surveillance of bat betacoronaviruses is crucial for understanding their spillover potential. We isolated bat sarbecoviruses from Rhinolophus cornutus bats in multiple locations in Japan. These viruses grew efficiently in cells expressing R.
Shin Murakami, Tomoya Kitamura, Hiromichi Matsugo, Haruhiko Kamiki, Ken Oyabu, Wataru Sekine, Akiko Takenaka-Uema, Yuko Sakai-Tagawa, Yoshihiro Kawaoka, Taisuke Horimoto   +9 more
doaj   +1 more source

Glomerular Localization and Expression of Angiotensin-Converting Enzyme 2 and Angiotensin-Converting Enzyme [PDF]

Journal of the American Society of Nephrology, 2006
Angiotensin-converting enzyme 2 (ACE2) expression has been shown to be altered in renal tubules from diabetic mice. This study examined the localization of ACE and ACE2 within the glomerulus of kidneys from control (db/m) and diabetic (db/db) mice and the effect of chronic pharmacologic ACE2 inhibition. ACE2 co-localized with glomerular epithelial cell
Minghao, Ye, Jan, Wysocki, Josette, William, Maria José, Soler, Ivan, Cokic, Daniel, Batlle   +5 more
openaire   +2 more sources

Oral Lisinopril Raises Tissue Levels of ACE2, the SARS-CoV-2 Receptor, in Healthy Male and Female Mice

Frontiers in Pharmacology, 2022
Angiotensin-converting enzyme 2 (ACE2) is the established cellular receptor for SARS-CoV-2. However, it is unclear whether ACE1 inhibitors (e.g., lisinopril) or angiotensin receptor blockers (e.g., losartan) alter tissue ACE2 expression.
Steven D. Brooks, Rachel L. Smith, Aline S. Moreira, Hans C. Ackerman   +3 more
doaj   +1 more source

Antecedent Administration of Angiotensin‐Converting Enzyme Inhibitors or Angiotensin II Receptor Antagonists and Survival After Hospitalization for COVID‐19 Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) utilizes the angiotensin‐converting enzyme‐2 (ACE‐2) receptor to enter human cells.
Alberto Palazzuoli, Massimo Mancone, Gaetano M. De Ferrari, Giovanni Forleo, Gioel G. Secco, Gaetano M. Ruocco, Fabrizio D'Ascenzo, Silvia Monticone, Anita Paggi, Marco Vicenzi, Anna G. Palazzo, Maurizio Landolina, Erika Taravelli, Guido Tavazzi, Francesco Blasi, Fabio Infusino, Francesco Fedele, Francesco G. De Rosa, Michael Emmett, Jeffrey M. Schussler, Kristen M. Tecson, Peter A. McCullough   +21 more
doaj   +1 more source

Conversion of Aβ43 to Aβ40 by the successive action of angiotensin‐converting enzyme 2 and angiotensin‐converting enzyme [PDF]

Journal of Neuroscience Research, 2014
The longer and neurotoxic species of amyloid‐β protein (Aβ), Aβ42 and Aβ43, contribute to Aβ accumulation in Alzheimer's disease (AD) pathogenesis and are considered to be the primary cause of the disease. In contrast, the predominant secreted form of Aβ, Aβ40, inhibits amyloid deposition and may have neuroprotective effects.
Shuyu, Liu, Junjun, Liu, Yukie, Miura, Chiaki, Tanabe, Tomoji, Maeda, Yasuo, Terayama, Anthony J, Turner, Kun, Zou, Hiroto, Komano   +8 more
openaire   +2 more sources

Vascular Angiotensin-Converting Enzyme 2 [PDF]

Circulation Research, 2010
See related article, pages 888–897 Through the actions of its main biological peptide, angiotensin (Ang) II, the renin–angiotensin system (RAS) has been implicated in atherosclerosis.1,2 The proatherogenic effect of Ang II may involve a variety of proinflammatory mechanisms that are largely independent from its effect on blood pressure.1 Ang II ...
Daniel, Batlle, Jan, Wysocki, Mirza S, Khan   +2 more
openaire   +2 more sources