Results 31 to 40 of about 362,216 (339)
In silico ADMET and molecular docking study on searching potential inhibitors from limonoids and triterpenoids for COVID-19 [PDF]
, 2020 Virtual screening of phytochemicals was performed through molecular docking, simulation, in silico ADMET and drug-likeness prediction to identify the potential hits that can inhibit the effects of SARS-CoV-2. Considering the published literature on medicinal importance, total 154 phytochemicals with analogous structure from limonoids and triterpenoids ...
arxiv +1 more source
Anais da Academia Brasileira de Ciências, 2022 COVID-19 is a pandemic disease caused by the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) responsible for millions of deaths worldwide.
ANTÔNIO V.B. DA SILVA +6 more
doaj +1 more source
Hypertension in Pregnancy, 2019 Objective: This study aimed to analyze the perinatal changes of plasma estradiol (E2) and angiotensin II (Ang II) in pregnant women with pulmonary arterial hypertension before and after cesarean section. Methods: Depending on pulmonary arterial pressure,
Yanshuang Wang +7 more
doaj +1 more source
Angiotensins and the Heart [PDF]
Hypertension, 2015 See related article, pp 389–395 Left ventricular hypertrophy is the most common cardiac complication of hypertension. Although the initial adaptations associated with cardiac hypertrophy are compensatory, ultimately abnormal ventricular function including diastolic dysfunction (impaired relaxation) and often heart failure may develop.1 Activation of ...
Lisa D. Wilsbacher +2 more
openaire +3 more sources
In silico comparison of spike protein-ACE2 binding affinities across species; significance for the possible origin of the SARS-CoV-2 virus [PDF]
Scientific Reports. 2021 Jun 24;11(1):13063. PMID: 34168168, 2020 The devastating impact of the COVID-19 pandemic caused by SARS coronavirus 2 (SARS CoV 2) has raised important questions about viral origin, mechanisms of zoonotic transfer to humans, whether companion or commercial animals can act as reservoirs for infection, and why there are large variations in SARS-CoV-2 susceptibilities across animal species ...
arxiv +1 more source
Insulin-Like Growth Factor-1 and Neuroinflammation
Frontiers in Aging Neuroscience, 2017 Insulin-like growth factor-1 (IGF-1) effects on aging and neurodegeneration is still controversial. However, it is widely admitted that IGF-1 is involved in the neuroinflammatory response.
Jose L. Labandeira-Garcia +8 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background The renin‐angiotensin system plays a crucial role in human physiology, and its main hormone, angiotensin, activates 2 G‐protein–coupled receptors, the angiotensin type‐1 and type‐2 receptors, in almost every organ.
Caglar Cosarderelioglu +12 more
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Formation of angiotensin III by angiotensin-converting enzyme [PDF]
Biochemical Journal, 1976 Angiotensin III is formed from des-Asp1 -angiotensin I by angiotensin-converting enzyme. The Km (11 muM) of the reaction is one-third of that for the conversion of angiotensin I into angiotensin II. As suggested by the Km values, bradykinin, peptide BPP9a and angiotensins II and III are better inhibitors of the formation of angiotensin II than of the ...
F E Dorer +3 more
openaire +3 more sources
Role of Melatonin in Angiotensin and Aging
Molecules, 2021 The cellular utilization of oxygen leads to the generation of free radicals in organisms. The accumulation of these free radicals contributes significantly to aging and several age-related diseases.
Ahmet Ozer Sehirli +3 more
doaj +1 more source
Pharmaceuticals, 2021 Angiotensin-Converting Enzyme 2 (ACE2) is an 805 amino acid protein encoded by the ACE2 gene expressed in various human cells, especially in those located in the epithelia. The primary function of ACE2 is to produce angiotensin (1–7) from angiotensin II (
Enrique Ambrocio-Ortiz +11 more
doaj +1 more source