Results 31 to 40 of about 655,327 (339)

Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. [PDF]

, 2016
We identified drug seeds for treating Huntington's disease (HD) by combining in vitro single molecule fluorescence spectroscopy, in silico molecular docking simulations, and in vivo fly and mouse HD models to screen for inhibitors of abnormal ...
Chen, Xigui, Finkbeiner, Steven, Fujita, Kyota, Homma, Hidenori, Ikura, Teikichi, Imamura, Tomomi, Ito, Nobutoshi, Kaye, Julia, Mao, Ying, Motoki, Kazumi, Nakabayashi, Makoto, Okano, Hideyuki, Okazawa, Hitoshi, Tagawa, Kazuhiko, Tamura, Takuya, Taniguchi, Juliana Bosso, Tomii, Kentaro, Yamada, Kazunori   +17 more
core   +2 more sources

Osmotic Adaptation by Na⁺-Dependent Transporters and ACE2: Correlation with Hemostatic Crisis in COVID-19

Biomedicines, 2020
COVID-19 symptoms, including hypokalemia, hypoalbuminemia, ageusia, neurological dysfunctions, D-dimer production, and multi-organ microthrombosis reach beyond effects attributed to impaired angiotensin-converting enzyme 2 (ACE2) signaling and elevated ...
Danah Muhanna, Shanvanth R. Arnipalli, Shashi B. Kumar, Ouliana Ziouzenkova   +3 more
doaj   +1 more source

Angiotensinergic Neurotransmissions in the Medial Amygdala Nucleus Modulate Behavioral Changes in the Forced Swimming Test Evoked by Acute Restraint Stress in Rats

Cells, 2021
We investigated the role of angiotensin II type 1 (AT1 receptor) and type 2 (AT2 receptor) and MAS receptors present in the medial amygdaloid nucleus (MeA) in behavioral changes in the forced swimming test (FST) evoked by acute restraint stress in male ...
Camila Marchi-Coelho, Willian Costa-Ferreira, Lilian L. Reis-Silva, Carlos C. Crestani   +3 more
doaj   +1 more source

Prognostic importance of emerging cardiac, inflammatory, and renal biomarkers in chronic heart failure patients with reduced ejection fraction and anaemia: RED-HF study [PDF]

, 2018
Aims: To test the prognostic value of emerging biomarkers in the Reduction of Events by Darbepoetin Alfa in Heart Failure (RED-HF) trial. Methods and results: Circulating cardiac [N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high ...
Alehagen, Arimoto, Balling, Bolignano, Cabassi, Dupont, Gaggin, Gravning, Grodin, Guisado Espartero, Haehling, Harrell, Jackson, Lassus, Lassus, Lok, Maisel, Maisel, McMurray, McMurray, Miller, Miller, Nagarajan, Park, Pascual-Figal, Pencina, Pencina, Pocock, Ponikowski, Rahimi, Rush, Shlipak, Swedberg, Tentzeris, Zamora   +34 more
core   +4 more sources

Angiotensin II-Induced Cardiovascular Fibrosis Is Attenuated by NO-Sensitive Guanylyl Cyclase1

Cells, 2020
In the NO/cGMP signaling cascade, relevant in the cardiovascular system, two NO-sensitive guanylyl cyclase (NO-GC) isoforms are responsible for NO-dependent cGMP generation.
Kathrin Broekmans, Jan Giesen, Lukas Menges, Doris Koesling, Michael Russwurm   +4 more
doaj   +1 more source

Angiotensin-Converting Enzyme 2 (ACE2) in the Context of Respiratory Diseases and Its Importance in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

Pharmaceuticals, 2021
Angiotensin-Converting Enzyme 2 (ACE2) is an 805 amino acid protein encoded by the ACE2 gene expressed in various human cells, especially in those located in the epithelia. The primary function of ACE2 is to produce angiotensin (1–7) from angiotensin II (
Enrique Ambrocio-Ortiz, Gloria Pérez-Rubio, Alma D. Del Ángel-Pablo, Ivette Buendía-Roldán, Leslie Chávez-Galán, Rafael de Jesús Hernández-Zenteno, Alejandra Ramírez-Venegas, Jorge Rojas-Serrano, Mayra Mejía, Rogelio Pérez-Padilla, Cristóbal Guadarrama-Pérez, Ramcés Falfán-Valencia   +11 more
doaj   +1 more source

Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet [PDF]

, 2017
AIM:To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS:Sprague-Dawley rats were fed with 8% NaCl high-salt (HS) or 0.4% NaCl ...
Cao, Gabriel Fernando, Choi, Marcelo Roberto, Della Penna, Silvana Lorena, Fernandez, Belisario Enrique, Gorzalczany, Susana Beatriz, Kouyoumdzian, Nicolás Martín, Roson, Maria Ines, Toblli, Jorge Eduardo   +7 more
core   +1 more source

Perinatal changes in estradiol and Ang II concentrations in pregnant women with pulmonary arterial hypertension and their correlation

Hypertension in Pregnancy, 2019
Objective: This study aimed to analyze the perinatal changes of plasma estradiol (E2) and angiotensin II (Ang II) in pregnant women with pulmonary arterial hypertension before and after cesarean section. Methods: Depending on pulmonary arterial pressure,
Yanshuang Wang, Hao Che, Kai Kang, Guosheng Zhao, Xiaoguang Li, Xiangming Che, Mingjun Xu, Liyun Zhao   +7 more
doaj   +1 more source

The diagnostic value of angiotensin, g-GT, blood lactate, and renal resistance index combined detection in acute kidney injury after neonatal asphyxia [PDF]

Journal of Medical Biochemistry
Background: To investigate the diagnostic value of angiotensin (Ang), gamma-glutamyltransferase (g-GT), blood lactic acid and renal resistive index (RRI) for acute kidney injury (AKI) after neonatal asphyxia.
Shi Xiaoqing, Dai Liying, Wang Ying, Deng Fang   +3 more
doaj   +1 more source

Aldosterone-Regulating Receptors and Aldosterone-Driver Somatic Mutations

Frontiers in Endocrinology, 2021
BackgroundSomatic gene mutations that facilitate inappropriate intracellular calcium entrance have been identified in most aldosterone-producing adenomas (APAs).
Jung Soo Lim, Jung Soo Lim, Samuel W. Plaska, Juilee Rege, William E. Rainey, William E. Rainey, Adina F. Turcu   +6 more
doaj   +1 more source