Results 71 to 80 of about 362,216 (339)
Biomedicines, 2020 COVID-19 symptoms, including hypokalemia, hypoalbuminemia, ageusia, neurological dysfunctions, D-dimer production, and multi-organ microthrombosis reach beyond effects attributed to impaired angiotensin-converting enzyme 2 (ACE2) signaling and elevated ...
Danah Muhanna +3 more
doaj +1 more source
Searching inhibitors for three important proteins of COVID-19 through molecular docking studies [PDF]
arXiv, 2020 The lack of recommended drugs or vaccines to deal with the COVID-19 is the main concern of this pandemic. The approved drugs for similar health problems, drugs under clinical trials, and molecules from medicinal plants extracts are investigated randomly to deal with the COVID-19 infection.
arxiv
Advanced Science, EarlyView.This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan +11 more
wiley +1 more source
Angiotensin II-Induced Cardiovascular Fibrosis Is Attenuated by NO-Sensitive Guanylyl Cyclase1
Cells, 2020 In the NO/cGMP signaling cascade, relevant in the cardiovascular system, two NO-sensitive guanylyl cyclase (NO-GC) isoforms are responsible for NO-dependent cGMP generation.
Kathrin Broekmans +4 more
doaj +1 more source
Review of COVID-19 Antibody Therapies [PDF]
arXiv, 2020 Under the global health emergency caused by coronavirus disease 2019 (COVID-19), efficient and specific therapies are urgently needed. Compared with traditional small-molecular drugs, antibody therapies are relatively easy to develop and as specific as vaccines in targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and thus attract ...
arxiv
Decoding Blastocystis‐Driven Mechanisms in Gut Microbiota and Host Metabolism
Advanced Science, EarlyView.Blastocystis, a prevalent gut microbe, interacts with the host through metabolic and immune pathways, influencing cardiometabolic health. This perspective explores its role in modulating short‐chain fatty acid production, tryptophan metabolism, and immune signaling, potentially impacting cholesterol absorption, glucose metabolism, and vascular health ...
Lei Deng, Kevin SW Tan
wiley +1 more source
Quantum Optical Immunoassay: Upconversion Nanoparticle-based Neutralizing Assay for COVID-19 [PDF]
arXiv, 2021 In a viral pandemic, a few important tests are required for successful containment of the virus and reduction in severity of the infection. Among those tests, a test for the neutralizing ability of an antibody is crucial for assessment of population immunity gained through vaccination, and to test therapeutic value of antibodies made to counter the ...
arxiv
Advanced Science, EarlyView.Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen +9 more
wiley +1 more source
Predictors and morphological properties of culprit healed plaques in patients with angina pectoris
Clinical Cardiology, Volume 45, Issue 12, Page 1199-1210, December 2022., 2022 Abstract Background Plaque healing may serve a vital function in the natural progression of atherosclerotic disease. This study sought to investigate predictors and morphological characteristics of healed plaque (HP) among angina pectoris (AP) patients.
Hongying Yao +5 more
wiley +1 more source
Revista Cubana de Investigaciones Biomédicas, 2020 Introduction: Iron is an essential metal for cellular homeostasis participating in important physiological processes. Concentrations of this metal in the organism need to be rigorously regulated, because the deficiency and excess of this metal cause ...
Renata Andrade Ávila +5 more
doaj