Results 241 to 250 of about 262,681 (286)
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The Angiotensin II Receptor and the Actions of Angiotensin II
Journal of Cardiovascular Pharmacology, 1990Angiotensin II (Ang II) is a potent effector peptide of the renin-angiotensin system that exerts a wide variety of physiological actions on the cardiovascular, renal, endocrine, and central and peripheral nervous systems. Angiotensin exerts its actions by binding to specific receptors in the plasma membrane of various tissues.
David E. Dostal, Michael J. Peach
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Inflammation and angiotensin II
The International Journal of Biochemistry & Cell Biology, 2003Angiotensin II (AngII), the major effector peptide of renin-angiotensin system (RAS), is now recognized as a growth factor that regulates cell growth and fibrosis, besides being a physiological mediator restoring circulatory integrity. In the last few years, a large number of experimental studies has further demonstrated that AngII is involved in key ...
Marta Ruiz-Ortega +5 more
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Conversion of Angiotensin I to Angiotensin II
Nature, 1967Results obtained with the blood bathed organ technique indicate that angiotensin I is converted rapidly to angiotensin II in the pulmonary circulation and not by an enzyme in the blood.
K. K. F. Ng, John R. Vane
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Angiotensin II and atherosclerosis
The American Journal of Cardiology, 2001Numerous clinical and laboratory data are now available supporting the hypothesis that the renin-angiotensin system is mechanistically relevant in the pathogenesis of atherosclerosis. The traditional role of the renin-angiotensin system in the context of blood pressure regulation has been modified to incorporate the concept that angiotensin II (Ang II)
Daiana Weiss +2 more
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Conversion of angiotensin I to angiotensin II
The American Journal of Medicine, 1976The angiotensin I converting enzyme has two important functions: it inactivates bradykinin and converts angiotensin I to angiotensin II. Inhibition of the enzyme blocks the renin-angiotensin system and decreases systemic blood pressure if the pressure is maintained or increased by renin. The enzyme occurs in a variety of tissues and cell forms.
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Life Sciences, 1985
Biological activities of asn1-,val5-angiotensin II (Hypertensin, Ciba, Asn1-,Val5-ANG II), ile5-angiotensin II (human angiotensin II, Ile5-ANG II) and sar1-angiotensin II (Sar1-ANG II) were compared in man. In 7 normal men 5 pmol/kg X min each of Asn1-,Val5-ANG II, Ile5-ANG II and Sar1-ANG II was infused iv from 0900 h to 0930 h at 1-week intervals ...
Tsuyoshi Kono +4 more
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Biological activities of asn1-,val5-angiotensin II (Hypertensin, Ciba, Asn1-,Val5-ANG II), ile5-angiotensin II (human angiotensin II, Ile5-ANG II) and sar1-angiotensin II (Sar1-ANG II) were compared in man. In 7 normal men 5 pmol/kg X min each of Asn1-,Val5-ANG II, Ile5-ANG II and Sar1-ANG II was infused iv from 0900 h to 0930 h at 1-week intervals ...
Tsuyoshi Kono +4 more
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CONVERSION OF ANGIOTENSIN I TO ANGIOTENSIN II IN SHEEP
Clinical and Experimental Pharmacology and Physiology, 1978SUMMARY1. The methodology for measurement of angiotensin I in whole blood is described.2. Angiotensin I was measured in arterial and venous blood samples from sodium‐loaded, sodium‐replete and sodium‐depleted sheep. Venous blood concentrations were higher than arterial angiotensin I concentrations.
John P. Coghlan +5 more
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Effect of angiotensin II and an angiotensin II inhibitor on renin secretion in the dog
American Journal of Physiology-Legacy Content, 1975This study examined the effect of angiotensin II (AII) and (Sar-1Gly-8) AII, a competitive inhibitor of AII, on renin release in anesthetized dogs. An intravenous infusion of AII (25 ng/kg per min) raised BP 24 mmHg and lowered plasma renin activity (PRA) from 18.8 plus or minus 2.8 to 6.2 plus or minus 1. 3 ng/ml per h (P smaller than .001). When the
S Taher +4 more
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Contribution of angiotensin II internalization to intrarenal angiotensin II levels in rats
American Journal of Physiology-Renal Physiology, 2002This study was designed to determine the involvement of AT1receptors in the uptake of ANG II in the kidney of rats exposed to differing salt intake. Male Wistar-Kyoto rats were treated with a normal-salt (NS; 1% NaCl, n = 7) or a low-salt (LS; 0.025% NaCl, n = 7) diet combined with (LS+Los, n = 7; NS+Los, n = 7) or without losartan (30 mg · kg−1· day−1)
Michèle Grima +4 more
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Nitric oxide–angiotensin II interactions in angiotensin II‐dependent hypertension
Acta Physiologica Scandinavica, 2000Many studies indicate that renal haemodynamic function in angiotensin II‐ (ANG II) dependent hypertension is not reduced as much as would be predicted from the elevated ANG II levels suggesting that counteracting renoprotective mechanisms are activated. One important renoprotective effect is mediated by increased levels of nitric oxide.
L. G. Navar +3 more
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