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Effect of angiotensin II infusion on glomerular angiotensin II receptor in rats
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1986Previous studies by other investigators have shown that sodium depletion causes down-regulation of angiotensin II receptors in renal glomeruli, which is ascribed to elevation of circulating angiotensin II levels. The present study was designed to determine whether elevation of circulating angiotensin II levels alone can down-regulate its own receptors ...
Tetsuya Imai +4 more
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Renal Accumulation of Circulating Angiotensin II in Angiotensin II–Infused Rats
Hypertension, 1996Abstract Previous studies have demonstrated that low-dose angiotensin II (Ang II) infusion for 14 days mimics two-kidney, one clip Goldblatt hypertension and increases intrarenal Ang II levels. The objective of the present study was to determine whether the augmented intrarenal Ang II is due to intrarenal accumulation of the ...
L. Gabriel Navar +3 more
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2016
Angiotensin II (Ang II) is the active peptide of the renin-angiotensin system (RAS). Ang II binds to AT1 and AT2 receptors to conduct signals. In mammals, losartan and PD123319 are AT1 and AT2 receptor antagonists, respectively, but these pharmacological blockers are not effective in other vertebrates.
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Angiotensin II (Ang II) is the active peptide of the renin-angiotensin system (RAS). Ang II binds to AT1 and AT2 receptors to conduct signals. In mammals, losartan and PD123319 are AT1 and AT2 receptor antagonists, respectively, but these pharmacological blockers are not effective in other vertebrates.
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Augmentation of intrarenal angiotensin II levels by chronic angiotensin II infusion
American Journal of Physiology-Renal Physiology, 1994The objective of this study was to investigate the singular role of elevated angiotensin II (ANG II) levels in the development of two-kidney, one-clip (2K1C) Goldblatt hypertension in the rat and specifically in the altered intrarenal ANG II levels that occur in the nonclipped kidney. As a substitute for the clipped kidney, chronic delivery of ANG II (
A M Von Thun +3 more
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Trends in Pharmacological Sciences, 2005
Angiotensin II and aldosterone produce pro-arrhythmic effects by several mechanisms, including the modulation of voltage-dependent K(+) channels involved in human cardiac repolarization. Drugs that inhibit the renin-angiotensin-aldosterone system exert anti-arrhythmic actions that are related to the blockade of the pro-arrhythmic actions of angiotensin
Lucía Núñez +4 more
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Angiotensin II and aldosterone produce pro-arrhythmic effects by several mechanisms, including the modulation of voltage-dependent K(+) channels involved in human cardiac repolarization. Drugs that inhibit the renin-angiotensin-aldosterone system exert anti-arrhythmic actions that are related to the blockade of the pro-arrhythmic actions of angiotensin
Lucía Núñez +4 more
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RADIOIMMUNOASSAY OF ANGIOTENSIN II IN PLASMA
Acta Endocrinologica, 1969ABSTRACT Specific antibodies were produced in rabbits with val5angiotensin II amid (Hypertensin®, Ciba) attached to succinyl-poly-l-lysine. Hypertensin was labelled with iodine-125 (125I) according to a modified Hunter-Greenwood procedure.
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Is the adrenal angiotensin receptor angiotensin II — or angiotensin III like?
Acta Endocrinologica, 1983Abstract. In order to determine whether the adrenal receptor is primarily directed at angiotensin II (All) or angiotensin III (AIII) the following in vitro experiments were performed examining aldosterone responsiveness in isolated glomerulosa cells.
Richard H. Underwood +3 more
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Conformational study of angiotensin II
Biopolymers, 1996Conformational free energy calculations using an empirical potential ECEPP/3 (Empirical Conformational Energy Program for Peptides, Version 3) were carried out on angiotensin II (AII) of sequence Asp-Arg-Val-Tyr-Ile-His-Pro-Phe to find the stable conformations of the free state in the unhydrated and the hydrated states. A conformational analysis of the
Young Ah Shin, Sung-Eun Yoo
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Angiotensin II and angiotensin III in rat blood.
Circulation Research, 1976Angiotensin II and its metabolites, [des-Asp-1]-angiotensin II (angiotensin III), [des-(Asp-1,Arg-2)]angiotensin II, and [des-(Asp-1,Arg-2,val-3)]angiotensin II, were measured in arterial and venous plasma from normal rats. Paper chromatography was used to separate the peptides which were measured with a radioimmunoassay method using an angiotensin II ...
P F Semple, J J Morton
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Biochemical and Biophysical Research Communications, 1990
Angiotensin II receptor binding sites in rat liver and PC12 cells differ in their affinities for a nonpeptidic antagonist, DuP 753, and p-aminophenylalanine6 angiotensin II. In liver, which primarily contains the sulfhydryl reducing agent-inhibited type of angiotensin II receptor, which we refer to as the AII alpha subtype, DuP 753 displays an IC50 of ...
Kwan Hee Kim, Robert C. Speth
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Angiotensin II receptor binding sites in rat liver and PC12 cells differ in their affinities for a nonpeptidic antagonist, DuP 753, and p-aminophenylalanine6 angiotensin II. In liver, which primarily contains the sulfhydryl reducing agent-inhibited type of angiotensin II receptor, which we refer to as the AII alpha subtype, DuP 753 displays an IC50 of ...
Kwan Hee Kim, Robert C. Speth
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