Results 51 to 60 of about 5,061,790 (379)

Grace periods in comparative effectiveness studies of sustained treatments [PDF]

, 2022
Researchers are often interested in estimating the effect of sustained use of a treatment on a health outcome. However, adherence to strict treatment protocols can be challenging for individuals in practice and, when non-adherence is expected, estimates of the effect of sustained use may not be useful for decision making.
arxiv   +1 more source

Structural Basis for Selectivity and Diversity in Angiotensin II Receptors

Nature, 2017
The angiotensin II receptors AT1R and AT2R serve as key components of the renin–angiotensin–aldosterone system. AT1R has a central role in the regulation of blood pressure, but the function of AT2R is unclear and it has a variety of reported effects.
Haitao Zhang, G. Han, A. Batyuk, A. Ishchenko, K. White, N. Patel, Anastasiia V. Sadybekov, B. Zamlynny, M. Rudd, K. Hollenstein, A. Tolstikova, T. White, M. Hunter, U. Weierstall, Wei Liu, K. Babaoglu, Eric L. Moore, R. Katz, J. Shipman, M. Garcia-Calvo, Sujata Sharma, P. Sheth, S. Soisson, R. Stevens, V. Katritch, V. Cherezov   +25 more
semanticscholar   +1 more source

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

Journal of Clinical Investigation, 1996
We tested the hypothesis that angiotensin II-induced hypertension is associated with an increase in vascular .O2- production, and characterized the oxidase involved in this process.
S. Rajagopalan, Sabine Kurz, T. Münzel, M. Tarpey, B. Freeman, K. Griendling, D. Harrison   +6 more
semanticscholar   +1 more source

Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet [PDF]

, 2017
AIM:To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS:Sprague-Dawley rats were fed with 8% NaCl high-salt (HS) or 0.4% NaCl ...
Cao, Gabriel Fernando, Choi, Marcelo Roberto, Della Penna, Silvana Lorena, Fernandez, Belisario Enrique, Gorzalczany, Susana Beatriz, Kouyoumdzian, Nicolás Martín, Roson, Maria Ines, Toblli, Jorge Eduardo   +7 more
core   +1 more source

Therapeutic potential of the renin angiotensin system in ischaemic stroke [PDF]

, 2016
The renin angiotensin system (RAS) consists of the systemic hormone system, critically involved in regulation and homeostasis of normal physiological functions [i.e.
Arroja, Mariana Moreira Coutinho, McCabe, Christopher, Reid, Emma   +2 more
core   +1 more source

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

Circulation Research, 1994
The signaling pathways involved in the long-term metabolic effects of angiotensin II (Ang II) in vascular smooth muscle cells are incompletely understood but include the generation of molecules likely to affect oxidase activity.
K. Griendling, C. Minieri, J D Ollerenshaw, R. Alexander   +3 more
semanticscholar   +1 more source

Senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and diastolic dysfunction [PDF]

, 2013
Background and objectiveSenescence marker protein 30 (SMP30) is assumed to behave as an anti-aging factor. Recently, we have demonstrated that deficiency of SMP30 exacerbates angiotensin II-induced cardiac hypertrophy, dysfunction and remodeling ...
Ishigami, Akihito, Kobayashi, Atsushi, Kubota, Isao, Misaka, Tomofumi, Miyata, Makiko, Saitoh, Shu-ichi, Shishido, Tetsuro, Suzuki, Satoshi, Takeishi, Yasuchika   +8 more
core   +1 more source

SARS‐CoV‐2 Is Linked to Brain Volume Loss in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The impact of SARS‐CoV‐2 infection on brain and spinal cord pathology in patients with multiple sclerosis (pwMS) remains unclear. We aimed to describe changes in brain lesion activity and brain and spinal cord volumes following SARS‐CoV‐2 infection.
Tomas Uher, Dominika Stastna, Ingrid Menkyova, Vaclav Capek, Jiri Lindner, Petra Nytrova, Jan Krasensky, Eliza Varju, Miguel D'haeseleer, Eva Kubala Havrdova, Dana Horakova, Manuela Vaneckova, Niels Bergsland   +12 more
wiley   +1 more source

Maternal plasma angiotensin 1-7 concentration is related to twin pregnancy chorionicity in the third trimester of pregnancy

Frontiers in Endocrinology
IntroductionTwin gestation is related to a higher risk of hypertensive disorders in pregnancy with possible risk stratification depending on chorionicity.
Paweł Pietruski, Katarzyna Kosińska-Kaczyńska, Agnieszka Osińska, Magdalena Zgliczyńska, Kinga Żebrowska, Katarzyna Popko, Anna Stelmaszczyk-Emmel   +6 more
doaj   +1 more source

Angiotensinergic innervation of rat and human mesenteric resistant blood vessels [PDF]

, 2007
In contrast to the current believe that angiotensin II (Ang II) only interacts with the sympathetic nervous system (SNS) as a circulating hormone, we document here the existence of an endogenous renin-angiotensin system (RAS) in the sympathetic coeliac ...
Eva Heiniger, Hans Imboden, Jaspal Patil, Oliver Muhlemann, Thomas Schaffner   +4 more
core   +1 more source