Results 51 to 60 of about 4,889,938 (291)

Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19

Critical Care, 2020
An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic.
W. Ni, Xiuwen Yang, Deqing Yang, J. Bao, Ran Li, Yongjiu Xiao, C. Hou, Haibin Wang, Jie Liu, Dong-hong Yang, Yu Xu, Zhaolong Cao, Zhancheng Gao   +12 more
semanticscholar   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Molecular targeting therapy with angiotensin II receptor blocker for prostatic cancer

Oncology Reviews, 2011
Angiotensin II (Ang-II) plays a key role as a vasoconstrictor in controlling blood pressure and electrolyte/fluid homeostasis. Recently it has also been shown that this peptide is a cytokine, acting as a growth factor in cardiovascular and stromal cells.
Hiroji Uemura, Hitoshi Ishiguro, Yoshinobu Kubota   +2 more
doaj   +2 more sources

Role of lipoxygenase products in the effects of angiotensin II in the isolated aorta and perfused heart of the rat

Mediators of Inflammation, 1995
The objective of this study was to determine whether arachidonate metabolites are involved in the vasoconstrictive effects of angiotensin II in rats. In the isolated perfused heart, dexamethasone (4 mg/kg) significantly suppressed the maximal decreases ...
J. P. M. Dam, E. van den Worm, W. Vleeming, M. J. Post, A. J. Porsius, J. Wemer   +5 more
doaj   +1 more source

A Computational Journey Toward an Optimal Design for Metamaterial Epicardial Passive Sleeves

Advanced Healthcare Materials, EarlyView.
Passive epicardial sleeves are evaluated in 3D in‐silico heart models to reveal how sleeve geometry, stiffness, anisotropy, and metamaterial architecture influence cardiac mechanics after myocardial infarction. A continuum‐to‐auxetic design exploration shows that region‐specific mechanical engagement can reduce infarct bulging and modulate torsional ...
Vahid Naeini, Emilio A. Mendiola, Ahmad Rafsanjani, Fergal B. Coulter, Qian Xiang, Jianyi Zhang, Peter Vanderslice, Vahid Serpooshan, Reza Avazmohammadi   +8 more
wiley   +1 more source

Angiotensin II Directly Increases Endothelial Calcium and Nitric Oxide in Kidney and Brain Microvessels In Vivo With Reduced Efficacy in Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The vasoconstrictor effects of angiotensin II via type 1 angiotensin II receptors in vascular smooth muscle cells are well established, but the direct effects of angiotensin II on vascular endothelial cells (VECs) in vivo and the mechanisms ...
Alejandra Becerra Calderon, Urvi Nikhil Shroff, Sachin Deepak, Audrey Izuhara, Greta Trogen, Alicia A. McDonough, Susan B. Gurley, Jonathan W. Nelson, János Peti‐Peterdi, Georgina Gyarmati   +9 more
doaj   +1 more source

Angiotensin-Converting Enzyme Inhibitor Does Not Suppress Renal Angiotensin II Levels in Angiotensin I–Infused Rats

Journal of Pharmacological Sciences, 2013
Angiotensin II (Ang II) infusion into rats elevates local angiotensin II levels through an AT1 receptor–dependent pathway in the kidney. We examined whether treatment with an angiotensin-converting enzyme (ACE) inhibitor, temocapril, or an AT1-receptor ...
Keisuke Ohnishi, Miki Murase, Daisuke Nakano, Nicolas Pelisch, Hirofumi Hitomi, Hiroyuki Kobori, Satoshi Morimoto, Hirohito Mori, Tsutomu Masaki, Koji Ohmori, Masakazu Kohno, Atsuhiro Ichihara, Akira Nishiyama   +12 more
doaj   +1 more source

Magnetic Bioprinting and Actuation of Stretchable Muscle Tissue

Advanced Healthcare Materials, EarlyView.
Human and murine myoblasts labeled with iron oxide nanoparticles are magnetically bioprinted into wrench‐shaped tissues, which are then anchored between two magnetic needles. Mechanical stretching of these tissues enhances both their maturation and functional performance. Abstract Engineering tissues with precise, long‐lasting shapes and the capability
Noam Demri, Lise Morizur, Simon Dumas, Giacomo Gropplero, Cécile Martinat, Stéphanie Descroix, Claire Wilhelm   +6 more
wiley   +1 more source

Multiple Mechanisms for the Action of Chymase Inhibitors

Journal of Pharmacological Sciences, 2012
Angiotensin II plays an important role in regulating blood pressure. Moreover, angiotensin II directly promotes organ damage by inducing expression of various genes, such as transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 ...
Shinji Takai, Denan Jin, Mizuo Miyazaki
doaj   +1 more source

Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension

Emerging Microbes and Infections, 2020
The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers
J. Meng, Guohui Xiao, Juanjuan Zhang, Xing He, M. Ou, Jing Bi, Rongqing Yang, Wencheng Di, Zhaoqin Wang, Zigang Li, Hong-yu Gao, Lei Liu, Guoliang Zhang   +12 more
semanticscholar   +1 more source