Effect of angiotensin II type 1 receptor blocker and angiotensin converting enzyme inhibitor on the intraocular growth factors and their receptors in streptozotocin-induced diabetic rats [PDF]
International Journal of Ophthalmology, 2017 AIM: To investigate the effect of angiotensin II type 1 receptor blocker (ARB) and angiotensin converting enzyme inhibitor (ACEI) on intraocular growth factors and their receptors in streptozotocin-induced diabetic rats.
Ik Soo Byon +5 more
doaj +1 more source
Angiotensin II Type 1 Receptor–associated Protein [PDF]
Hypertension, 2013 See related article, pp 1203–1210 Most physiological actions of angiotensin (Ang) II are mediated by its binding to the Ang II type 1 receptors (AT1R). These include, but are not limited to, vasoconstriction, increased renal sodium and water reabsorption, as well as the stimulation of aldosterone release, thirst, vasopressin secretion, and cell growth.
Jorge F, Giani +2 more
openaire +2 more sources
Impaired endothelial function of the retinal vasculature in hypertensive patients [PDF]
, 2004 <p><b>Background and Purpose:</b> Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation.</p> <p ...
Delles, C. +5 more
core +1 more source
Advanced Science, EarlyView.Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li +11 more
wiley +1 more source
Modulation of the renin-angiotensin system against COVID-19: A path forward?
International Journal of Infectious DiseasesSoon after the pandemic outbreak in 2020, it was proposed that binding of SARS-CoV-2 to the angiotensin converting enzyme-2 may explain most of COVID-19’s manifestations.
Serge Camelo +11 more
doaj +1 more source
Effect of Angiotensin II Type 1 Receptor Blockade on Cardiac Remodeling in Angiotensin II Type 2 Receptor Null Mice [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 To clarify the possible involvement of uninhibited angiotensin II (Ang II) type 2 (AT 2 ) receptor stimulation in the effects of an Ang II type 1 (AT 1 ) receptor blocker, valsartan, we examined the cardiovascular remodeling induced by aortic banding with the use of wild-type ...
Lan, Wu +7 more
openaire +2 more sources
Exogenous angiotensin II does not facilitate norepinephrine release in the heart [PDF]
, 2002 Studies on the effect of angiotensin II on norepinephrine release from sympathetic nerve terminals through stimulation of presynaptic angiotensin II type 1 receptors are equivocal.
Alberts, G. (Gooitzen) +6 more
core
A novel mechanism of action for angiotensin-(1-7) via the angiotensin type 1 receptor [PDF]
, 2016 No abstract ...
Nicklin, Stuart A.
core +1 more source
Advanced Science, EarlyView.SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li +14 more
wiley +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source