Results 121 to 130 of about 131,203 (163)

Type 1 angiotensin II receptors of adrenal tumors

Steroids, 1995
The present study was designed to clarify the transcriptional regulation of the human type 1 angiotensin II receptor (AT1) gene and its pathophysiological roles in steroidogenesis by adrenal tumors. A cDNA encoding type 1 angiotensin II receptor (AT1) was isolated from a human liver cDNA library encoding a protein of 359 amino acids with seven ...
H, Nawata, R, Takayanagi, K, Ohnaka, Y, Sakai, K, Imasaki, T, Yanase, S, Ikuyama, S, Tanaka, K, Ohe   +8 more
openaire   +2 more sources

Expression of type 1 angiotensin II receptors in human aldosteronomas

Endocrine Research, 1995
Type 1 angiotensin II (AII) receptors (AT1 receptors), besides stimulation of aldosterone secretion, seem to transduce the growth factor-like activity of AII on glomerulosa cells. Although a local renin-angiotensin system and AII synthesis have been found in human adrenals and aldosteronomas, it is unclear whether aldosteronomas express AT1 receptors ...
R. SARZANI, OPOCHER, GIUSEPPE, P. DESSIFULGHERI, V. PACI, G. COLA, S. ROCCO, B. VIANELLO, MANTERO, FRANCO, A. RAPPELLI   +8 more
openaire   +2 more sources

Endocytosis and signaling of angiotensin II type 1 receptor

2023
A vasoactive octapeptide angiotensin II (Ang II) hormone is the key regulator of the renin-angiotensin system (RAS). It binds with the two different plasma membrane receptors like angiotensin II type 1 (AT1) and type 2 (AT2) and consequence various biological responses occur. Further, AT1 has two subtypes such as AT1A and AT1B.
openaire   +2 more sources

Gene Polymorphism of Angiotensin II Type 1 and Type 2 Receptors

Current Pharmaceutical Design, 2013
Renin-angiotensin system (RAS) plays a key role in pathogenesis of cardiovascular disease and in the responsiveness for various types of medications. A large number of genetic investigations have been carried out to examine the association between gene variants of RAS and predisposition to cardiovascular diseases, such as hypertension, coronary artery ...
Tomohiro, Katsuya, Ryuichi, Morishita
openaire   +2 more sources

The distribution of angiotensin II type 1 receptors, and the tissue renin-angiotensin systems

Molecular Medicine Today, 1995
Since its discovery, the functions of the renin-angiotensin system (RAS) have attracted a great deal of attention, and the roles it plays under normal conditions, and in disease, acquire a deepening significance with every year. In general, the RAS has been considered largely in terms of its roles in sodium and potassium homeostasis and the regulation ...
G P, Vinson, M M, Ho, J R, Puddefoot
openaire   +2 more sources

Type 1 angiotensin II receptors in rat and human sperm

Journal of Endocrinology, 1995
Abstract The physiological factors which induce and maintain mammalian sperm maturation and motility generally remain unclear, although several agents are known to be involved. We describe here the application of immunocytochemical and immunoblotting methods to identify the angiotensin II type 1 (AT1) receptor in the tails of ejaculated rat and
G P, Vinson, J R, Puddefoot, M M, Ho, S, Barker, J, Mehta, E, Saridogan, O, Djahanbakhch   +6 more
openaire   +2 more sources

The Angiotensin II Type 1 Receptor Antagonists

Archives of Internal Medicine, 1995
The angiotensin II (AII) type 1 receptor antagonists represent a new pharmacologic class of drugs that are specifically designed to displace All from its type 1 receptor subtype. These drugs antagonize AII-induced biologic actions, including smooth-muscle contraction, sympathetic pressor mechanisms, and aldosterone release.
openaire   +1 more source

[Angiotensin II type 1 and type 2 receptor].

Nihon rinsho. Japanese journal of clinical medicine, 2009
The octapeptide angiotensin II (AngII) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and contributes to the progression of cardiovascular remodeling. AngII activates AngII type 1 (AT1) receptor and type 2 (AT2) receptor, both of which belong to the seven-transmembrane, G protein-coupled receptor family.
Hiroshi, Akazawa, Issei, Komuro
openaire   +1 more source

Cloning and characterization of a human angiotensin II type 1 receptor

Biochemical and Biophysical Research Communications, 1992
A human liver cDNA library was screened using a rat type 1 angiotensin II receptor cDNA coding sequence as a probe. cDNA clones were isolated which encoded a protein of 359 amino acids that shared 94.4% and 95.3% identify to rat and bovine type 1 angiotensin II receptors, respectively.
D J, Bergsma, C, Ellis, C, Kumar, P, Nuthulaganti, H, Kersten, N, Elshourbagy, E, Griffin, J M, Stadel, N, Aiyar   +8 more
openaire   +2 more sources

The Genomic Organization of Human Angiotensin II Type 1 Receptor

Biochemical and Biophysical Research Communications, 1994
As a step toward the elucidation of human Ang II type 1 receptor gene expression, the genomic organization of the human AT1 receptor was investigated. Comparison of the genomic DNA and cDNA sequences revealed that it consists of at least five exons. The length of the AT1 receptor gene is greater than 55 kb, and the size of the exons ranges from 59 to 2,
D F, Guo, H, Furuta, M, Mizukoshi, T, Inagami   +3 more
openaire   +2 more sources