Results 131 to 140 of about 131,203 (163)
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Evidence for the presence of angiotensin II-type 1 receptors in brain
Brain Research Bulletin, 1990Angiotensin II receptor subtypes have been localized in brain by using a novel nonpeptide AII-type 1 receptor antagonist to compete with [125I]AII binding in an autoradiographic study. These data contrast with results obtained using the AII-type 2 antagonist PD123177.
J K, Wamsley +3 more
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Assessment of Inverse Agonism for the Angiotensin II Type 1 Receptor
2010The angiotensin II (AngII) type 1 (AT₁) receptor is a seven-transmembrane G-protein-coupled receptor that plays a regulatory role in the physiological and pathological processes of the cardiovascular system. AT₁ receptor inherently shows constitutive activity even in the absence of AngII, and it is activated not only by AngII but also by AngII ...
Hiroshi, Akazawa +3 more
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Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
Nature Cell Biology, 2004The angiotensin II type 1 (AT1) receptor has a crucial role in load-induced cardiac hypertrophy. Here we show that the AT1 receptor can be activated by mechanical stress through an angiotensin-II-independent mechanism. Without the involvement of angiotensin II, mechanical stress not only activates extracellular-signal-regulated kinases and increases ...
Yunzeng, Zou +18 more
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Role of Angiotensin II Type 1 Receptor in Angiotensin II-Induced Cytokine Production in Macrophages
Journal of Interferon & Cytokine Research, 2011This study was aimed to investigate the regulatory effects of angiotensin II (Ang II) on the expression of Ang II type 1 (AT1) receptor and to characterize the mechanism underlying AT1 receptor promotion of inflammatory cytokines and reactive oxygen species (ROS).
Feng, Guo +5 more
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Regulation of angiotensin II type 1 (AT1) receptor function
Regulatory Peptides, 1999The type 1 angiotensin receptor (AT1) mediates the important biological actions of the peptide hormone, angiotensin II (AngII), by activating an array of intracellular signaling pathways. The unique temporal arrangement and duration of AngII-stimulated signals suggests a hierarchy of post-AT1 receptor binding events that permits activation of selective
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Role of Type 1 and Type 2 Angiotensin Receptors in Angiotensin II–Induced Cardiomyocyte Hypertrophy
Hypertension, 1996We compared the ability of angiotensin II (Ang II) to induce hypertrophy of neonatal rat ventricular myocytes with that of endothelin-1. Over 72 hours, Ang II (1 μmol/L) increased the ratio of protein to DNA by less than 10%, whereas endothelin-1 (100 nmol/L) produced a 28% increase.
G W, Booz, K M, Baker
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The Detection of Antibodies to the Angiotensin II-Type 1 Receptor in Transplantation
2013The detection of auto-antibodies detection is a major aspect of patient's immunomonitoring. Antibodies directed against the heart and kidney Angiotensin II type 1 receptor (AT1R) play a major role in antibody mediated rejection after heart and kidney transplantation and in obliterative vasculopathy of autoimmune diseases. Here, a sandwich enzyme-linked
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Angiotensin II type 1 receptor antagonists
Biochemical Pharmacology, 2000Patrick M.L Vanderheyden +2 more
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