Results 111 to 120 of about 272,686 (351)

Acute Urinary Bladder Distension Triggers ICAM-1-mediated Renal Oxidative Injury via the Norepinephrine–renin–angiotensin II System in Rats

Journal of the Formosan Medical Association, 2009
Acute urinary bladder distension (AUBD) can activate bladder mechanical afferent and renal sympathetic nerves, which contributes to renal vasoconstriction.
Show-Shing Chen, Wang-Chuan Chen, Satoshi Hayakawa, Ping-Chia Li, Chiang-Ting Chien   +4 more
doaj   +1 more source

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

Modeling Angiotensin II‐mediated activation of the Angiotensin II Type 1 Receptor

The FASEB Journal, 2018
It is well known that agonist binding to GPCRs engages a structural rearrangement, leading to GDP disassociation from the G‐alpha subunit and subsequent GTP association and activation of the Gα subunit. However, the structural mechanism mediating intramolecular molecular communication between the agonist binding pocket and G‐alpha ...
Shane D. Anderson, Wesley M. Botello‐Smith, Yun Lyna Luo, Bradley T. Andresen   +3 more
openaire   +1 more source

Angiotensin II type 1 receptor blocker-induced immune thrombocytopenia: a case report [PDF]

, 2013
INTRODUCTION: The development of thrombocytopenia after a dose increase in losartan and subsequently after switching the patient to valsartan is reported.
David Schnee, Dhiren K. Patel, Nikhil Bilkha   +2 more
core   +1 more source

Single‐Cell Transcriptomic Atlases of Camels and Cattle Unravel Molecular Evolution of Digestive and Metabolic Systems

Advanced Science, EarlyView.
We generated multi‐tissue single‐cell transcriptomic atlases of camels and cattle, uncovering conserved and lineage‐specific cellular features across digestive and metabolic systems. Cross‐species comparisons revealed the evolutionary origin of the camel glandular sac and identified novel cell populations linked to physiological specialization ...
Tao Shi, Huiquan Shan, Haoping Wang, Xi Guo, Houcheng Li, Bo Han, Senlin Zhu, Fei Wang, Guanghui Tan, Zhannur Niyazbekova, Jilong Ren, Yaqi Zhou, Qi Zhang, Weijie Zheng, Minghui Jia, Ao Zhang, Xuesha Cao, Huizeng Sun, Dongxiao Sun, Lingzhao Fang, Yi Zheng, Xihong Wang, Yu Jiang   +22 more
wiley   +1 more source

Novel Antihypertensive Medications to Target the Renin-Angiotensin System: Mechanisms and Research

Reviews in Cardiovascular Medicine
An estimated 1.28 billion individuals in the global population suffer from hypertension. Importantly, uncontrolled hypertension is strongly linked to various cardiovascular and cerebrovascular diseases.
Zhe Jiang, Changlin Zhai, Guanmin Tang
doaj   +1 more source

Transient receptor potential melastatin 7 cation channel kinase new player in angiotensin II–induced hypertension [PDF]

, 2016
Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein comprising a magnesium (Mg2+)/cation channel and a kinase domain. We previously demonstrated that vasoactive agents regulate vascular TRPM7.
Antunes, Tayze T., Callera, Glaucia E., He, Ying, Ryazanov, Alexey G., Ryazanov, Lillia V., Shrier, Alvin, Stewart, Duncan J., Touyz, Rhian, Yogi, Alvaro, Zhai, Alexander   +9 more
core   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Molecular-genetic assessment of angiotensin-converting enzyme hyperactivity determinancy risk at hemorrhagic fever with renal syndrome [PDF]

Саратовский научно-медицинский журнал, 2010
The research aimed to explore the changes of angiotensin-converting enzyme (ACE) blood activity and polymorphism of the angiotensin II type 1 receptor gene as disease predictor at hemorrhagic fever with renal syndrome (HFRS). In exami¬nation 409 patients
A.A. Baygildina, D.V. Islamgulov, F.Kh. Kamilov, T.A. Khabelova, I.R. Minniakhmetov   +4 more
doaj  

Candesartan inhibits inflammation through an angiotensin II type 1 receptor independent way in human embryonic kidney epithelial cells

Anais da Academia Brasileira de Ciências, 2019
: Besides stimulating vasoconstriction, Angiotensin II is also well known in inducing reactive oxygen species and promoting inflammatory phenotype switch via its type 1 receptor.
YING YU, HAIFENG JIANG, YANGYANG NIU, XIAOQIN ZHANG, YINGYING ZHANG, XI LIU, TAO QI, CHEN YU   +7 more
doaj   +1 more source