Results 51 to 60 of about 272,686 (351)

Exogenous and endogenous angiotensin-II decrease renal cortical oxygen tension in conscious rats by limiting renal blood flow [PDF]

, 2016
Our understanding of the mechanisms underlying the role of hypoxia in the initiation and progression of renal disease remains rudimentary. We have developed a method that allows wireless measurement of renal tissue oxygen tension in unrestrained rats ...
Emans, Tonja, Evans, Roger, Janssen, Ben, Joles, Jaap, Koeners, Maarten, Krediet, C T Paul, Malpas, Simon, Ow, Connie P C, Pinkham, Maximillian   +8 more
core   +8 more sources

Assessment of cardiac hemodynamics indicators in patients with arterial hypertension and non-alcoholic fatty liver disease depending on angiotensin II type 1 receptor A1166C gene polymorphism

Zaporožskij Medicinskij Žurnal, 2018
Aim of study is to estimate the indicators of cardiac hemodynamics in patients with arterial hypertension and non-alcoholic fatty liver disease depending on angiotensin II type 1 receptor (A1166C) gene polymorphism. Materials and methods.
O. Ya. Babak, M. M. Zaitseva
doaj   +1 more source

Renin-Angiotensin A1166C Polymorphism and the Rrisk of Stroke [PDF]

Journal of Cell and Molecular Research, 2015
Stroke is the leading cause of death and disability in the world after the cancer and cardiovascular diseases. Genetic factors have main significance to got stroke.
Peyman Zargari, Mohammad R. Ghasemi, Maryam Pirhoushiaran, Veda Vakili, Javad Hami, Mohammad Taghi Farzadfard, Payam Sasan-Nezhad, Mahmood R. Azarpazhooh, Ariane Sadr-Nabavi   +8 more
doaj   +1 more source

Pretransplant Sensitization Against Angiotensin II Type 1 Receptor Is a Risk Factor for Acute Rejection and Graft Loss

American Journal of Transplantation, 2013
The angiotensin II type 1 receptor (AT1R) is an emerging target of functional non‐HLA antibodies (Ab). We examined the potential of determining the degree of presensitization against AT1R as a risk factor for graft survival and acute rejection (AR).
M. Giral, Y. Foucher, A. Dufay, J. V. Huyen, K. Renaudin, A. Moreau, A. Philippe, B. Hegner, R. Dechend, H. Heidecke, S. Brouard, A. Cesbron, S. Castagnet, A. Devys, J. Soulillou, D. Dragun   +15 more
semanticscholar   +1 more source

Involvement of angiotensin II in the remodeling induced by a chronic decrease in blood flow in rat mesenteric resistance arteries [PDF]

, 2010
Blood flow reduction induces inward remodeling of resistance arteries (RAs). This remodeling occurs in ischemic diseases, diabetes and hypertension. Nonetheless, the effect of flow reduction per se, independent of the effect of pressure or metabolic ...
A.L. Guihot, B. Toutain, C. Baron-Menguy, D. Henrion, E. Vessieres, J.F. Subra, L. Loufrani, M. Cousin, M.A. Custaud, O. Dumont   +9 more
core   +3 more sources

Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease

Clinical and Experimental Hypertension, 2018
Renin angiotensin system (RAS) is an endogenous hormone system involved in the control of blood pressure and fluid volume. Dysregulation of RAS has a pathological role in causing cardiovascular diseases through hypertension.
Misbah Hussain, Fazli Rabbi Awan
doaj   +1 more source

Differential renal effects of candesartan at high-and ultra-high doses in diabetic mice: potential role of  ACE2/AT2R/Mas [PDF]

, 2016
High doses of Ang II receptor (AT1R) blockers (ARBs) are renoprotective in diabetes. Underlying mechanisms remain unclear. We evaluated whether high/ultra-high doses of candesartan (ARB) up-regulate angiotensin-converting enzyme 2 (ACE2)/Ang II type 2 ...
Antunes, Tayze, Briones, Ana M., Burns, Kevin, Callera, Glaucia, Correa, Jose, Gutsol, Alexey, He, Ying, Montezano, Augusto C., Moorman, Danielle, Nguyen Dinh Cat, Aurelie, Touyz, Rhian M.   +10 more
core   +1 more source

Angiotensin II Type 1 Receptor Mediates Angiotensin II Inhibition on BKCa Channels [PDF]

Biophysical Journal, 2012
The renin-angiotensin system (RAS) is a critical regulator of sodium balance, extracellular fluid volume, vascular resistance, and, ultimately, arterial blood pressure. The key RAS molecule angiotensin II type 1 receptor (AT1R), and another major determinant of vascular tone, the large conductance calcium-activated potassium (BKCa) channel, are both ...
Zhang, Zhu, Lu, Rong, Stefani, Enrico, Toro, Ligia   +3 more
openaire   +1 more source

Regulation of the renal angiotensin II receptor gene in acute unilateral ureteral obstruction [PDF]

, 1994
Regulation of the renal angiotensin II receptor gene in acute unilateral ureteral obstruction. We have shown that acute (24-hr) unilateral ureteral obstruction (UUO) induces the genes encoding for renin, in juxtaglomerular apparatuses and in tubules, for
Pimentel, J. Luis, Wang, Susheng, Martinez-Maldonado, Manuel   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source