Results 181 to 190 of about 146,093 (222)

Significance of angiotensin type 1 receptor blockade: why are angiotensin II receptor blockers different?

The American Journal of Cardiology, 1999
The angiotensin II receptor blockers (ARBs) are safe and effective agents in the treatment of hypertension, and they have potential in treating other cardiovascular disorders such as heart failure. These drugs share a common mechanism of action: They selectively block the angiotensin type 1 (AT1) receptor.
T. Unger
openaire   +3 more sources

The angiotensin II type 1 receptor blocker valsartan attenuates graft vasculopathy

Basic Research in Cardiology, 2004
Transplant arteriosclerosis remains the major cause of graft failure after cardiac transplantation. Here, we investigated the effects of the angiotensin II type 1 receptor blocker valsartan on the development of transplant arteriosclerosis in a murine model of cardiac transplantation.Hearts from DBA/2 (H-2(d)) mice were heterotopically transplanted ...
Tetsufumi, Yamamoto, Masataka, Sata, Daiju, Fukuda, Shinichi, Takamoto   +3 more
openaire   +3 more sources

Angiotensin‐converting enzyme inhibitors and angiotensin II type 1 receptor blockers after renal transplantation

Clinical Transplantation, 2009
Abstract:  Renin‐angiotensin system blockade retards the progression of diabetic and non‐diabetic chronic kidney disease of the native kidneys. Though most patients suffer from a significant renal insufficiency (chronic kidney disease stage III) and a concomitant heart disease after renal transplantation, there is up to now no evidence supporting the ...
C, Morath, B, Schmied, A, Mehrabi, J, Weitz, J, Schmidt, J, Werner, M W, Buchler, M, Morcos, P P, Nawroth, V, Schwenger, B, Doehler, G, Opelz, M, Zeier   +12 more
openaire   +2 more sources

Effect of angiotensin II type 1 receptor blocker on osteoporotic rat femurs

Pharmacological Reports, 2012
Osteoblasts and osteoclasts are known to express Ang II type I (AT1) receptor in cell cultures, suggesting the existence of local renin-angiotensin system (RAS) in bone. This study was designed to investigate the effects of losartan as AT1 receptor blocker on ovariectomized rats' femur.Losartan (5 mg/kg/day) was administered via oral gavage for 8 weeks.
Ozdemir S., Donmez B.O., Sarikanat M., Yaras N., Koc P., Demir N., Karayalcin B., Oguz N.   +7 more
openaire   +2 more sources

Angiotensin II type 1 receptor blocker inhibits pulmonary injury.

Clinical and investigative medicine. Medecine clinique et experimentale, 2005
Pulmonary damage and fibrosis may be the result of diverse forms of injury and there is an association between pulmonary diseases and cardiovascular events. The purpose of this study was to evaluate the effects of an angiotensin II type 1 receptor blocker, valsartan, on systemic, cellular, and fibrotic consequences of pulmonary injury induced by the ...
G B John, Mancini, Nasreen, Khalil
openaire   +1 more source

Telmisartan has the strongest binding affinity to angiotensin II type 1 receptor: comparison with other angiotensin II type 1 receptor blockers.

International journal of clinical pharmacology research, 2005
There is a growing body of evidence that the renin-angiotensin system (RAS) plays a pivotal role in the pathogenesis of cardiovascular diseases. Indeed, large clinical trials have demonstrated a substantial benefit of the blockade of this system for cardiovascular-organ protection. Although several types of angiotensin II type 1 (AT1) receptor blockers
H, Kakuta, K, Sudoh, M, Sasamata, S, Yamagishi   +3 more
openaire   +1 more source

Ultrastructure and mechanical property of angiotensin II-stimulated tubular cells pretreated with angiotensin II type 1 receptor blocker

2011 IEEE Nanotechnology Materials and Devices Conference, 2011
Atomic force microscopy (AFM) has become an important device to visualize various cells and biological materials for non-invasive imaging. The major advantage of AFM compared to the conventional optical and electron microscopes is its convenience. Sample preparation for AFM does not need special coating or vacuum as a procedure.
Gi-Ja Lee, null Ji-Hye Kim, null Sung-Wook Kang, null Su-Jin Chae, Kyung-Hwan Jeong, Hun-Kuk Park   +5 more
openaire   +1 more source

[Current topic of next generation of angiotensin II type 1 receptor blockers].

Nihon rinsho. Japanese journal of clinical medicine, 2012
Angiotensin receptor blockers(ARBs) are used as the first-choice anti-hypertensives for prevention of multiple organ damage. Recently, the next-generation ARBs have been expected to have more preventive effect for cardiovascular diseases. For example, metabosartans which have a partial agonistic effect of peroxisome proliferator-activated receptor ...
Masaki, Mogi, Masatsugu, Horiuchi
openaire   +1 more source

Impact of angiotensin I converting enzyme inhibitors and angiotensin II type 1 receptor blockers on survival in patients with advanced non-small-cell lung cancer undergoing first-line platinum-based chemotherapy

Journal of Cancer Research and Clinical Oncology, 2009
S. Wilop, S. Hobe, M. Crysandt, Albert Esser, R. Osieka, E. Jost   +5 more
semanticscholar   +1 more source

The effects of different angiotensin II type 1 receptor blockers on the regulation of the ACE-AngII-AT1 and ACE2-Ang(1-7)-Mas axes in pressure overload-induced cardiac remodeling in male mice.

Journal of Molecular and Cellular Cardiology, 2016
Xingxu Wang, Y. Ye, H. Gong, Jian Wu, Jie Yuan, Shijun Wang, Pei-pei Yin, Z. Ding, Le Kang, Qiu Jiang, Weijing Zhang, Yang Li, J. Ge, Y. Zou   +13 more
semanticscholar   +1 more source