Results 181 to 190 of about 48,105 (216)

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Role of Angiotensin-Converting Enzyme in Cognitive Aging: Evidence from Preclinical and Clinical Studies. [PDF]

Front Drug Discov (Lausanne)
Smith J, Dobariya P, Kadam TR, More SS.
europepmc   +1 more source

Associations Between Body Mass Index and Clinical Outcomes Stratified by Age in Patients Undergoing Maintenance Hemodialysis

Hemodialysis International, EarlyView.
ABSTRACT Background Our study aimed to investigate the association between body mass index and clinical outcomes by age group in a population‐based cohort of patients having HD. Methods The data collected by the Health Insurance Review and Assessment Service during HD quality assessment programs and the claims and death data were retrospectively ...
Seok Hui Kang, So Young Park, Yu Jeong Lim, Bo Yeon Kim, Ji Young Choi, Jun Young Do   +5 more
wiley   +1 more source

Impact of herpes zoster and post-zoster SGLT2 inhibitors initiation on cardiorenal outcomes in type 2 diabetes mellitus. [PDF]

BMC Endocr Disord
Wu MZ, Tsang CT, Peng C, Huang JY, Guo R, Tse YK, Chan YH, Lee CH, Zhang JN, Gu WL, Li XL, Ren QW, Yiu KH.   +12 more
europepmc   +1 more source

Effectiveness of galcanezumab versus topiramate, amitriptyline, and other select traditional oral migraine preventives with evidence of efficacy: 3‐Month results from the TRIUMPH study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To compare the 3‐month effectiveness of galcanezumab with select traditional oral migraine preventive (TOMP) medications recommended by scientific societies (TOMP efficacy subset) and with the most frequently used individual TOMP medications.
Shivang Joshi, Cristina Tassorelli, Manjit Matharu, Taoufik Alsaadi, Carlos Vallarino, Lars Viktrup, Maurice Vincent, Rebecca L. Robinson   +7 more
wiley   +1 more source

Primary care Adherence to Heart failure guidelines in post-discharge, evaluation & routine management (PATHFINDER): a randomized controlled trial. [PDF]

ESC Heart Fail
Maiorana A, Dai L, Dorje T, Gootjes J, Shah A, Dembo L, Hillis GS, Jacques A, Chih H, Rankin J, Atherton JJ, Robinson S, Reid CM.   +12 more
europepmc   +1 more source

Preventive Effect of Mineralocorticoid Receptor Antagonists Against Proteinuria Induced by Atezolizumab Plus Bevacizumab Therapy in Hepatocellular Carcinoma: A Multicenter Retrospective Study

Hepatology Research, EarlyView.
Mineralocorticoid receptor antagonists are known to reduce proteinuria in chronic kidney disease, but their effectiveness in preventing bevacizumab‐related proteinuria has not been well established. In the present multi‐institutional retrospective study, we found that these agents significantly delay the onset of moderate or higher grade proteinuria ...
Tomoki Hori, Kazuhiro Yamamoto, Hiroshi Aoi, Yusuke Koizumi, Makoto Kuromatsu, Aiko Fukui, Hiroyo Okamoto, Atsushi Hirata, Kentaro Shinmori, Yuki Imanaka, Miyu Namba, Keisuke Nakanishi, Syunsuke Kitamura, Hideo Tsushima, Ikuko Yano, Kei Moriya, Masaru Matsui, Shigeki Ikushima   +17 more
wiley   +1 more source

GLP-1 Receptor Agonists and Blood Pressure: A State-of-the-Art Review of Mechanisms, Evidence, and Clinical Implications. [PDF]

Am J Hypertens
Moiz A, Zolotarova T, Filion KB, Eisenberg MJ.   +3 more
europepmc   +1 more source

Practical recommendations for treating patients with chronic kidney disease in Australia: a multidisciplinary approach

Internal Medicine Journal, EarlyView.
Abstract Background Chronic kidney disease (CKD) is a significant public health challenge in Australia, affecting ~10% of the adult population and contributing to substantial morbidity and mortality. Diabetes, hypertension, cardiovascular disease and CKD frequently co‐exist; therefore, a multidisciplinary approach is necessary to manage these ...
M. P. Schlaich, W. P. Abhayaratna, R. Audehm, E. I. Ekinci, R. J. MacIsaac, A. J. Nelson, A. Sharma, C. Pollock   +7 more
wiley   +1 more source

Contemporary Guideline-Directed Medical Therapy for Heart Failure in the United States: The EMPACE Study. [PDF]

J Am Heart Assoc
Greene SJ, Adam A, Schmedt N, Carlsen C, Brand M, Davies E, Jouaville Abrouk LS, Prochaska JH, Tran P, Alhamdow A.   +9 more
europepmc   +1 more source