Bridging pathogenesis and therapy in focal segmental glomerulosclerosis: the rise of dual receptor blockade with sparsentan. [PDF]
Abid MA, Abid MH, Hasan AH, Afzal MD.
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YK-4-250, a synthetic telmisartan-tempol conjugate: crystal structure of a stabilized free radical containing an angiotensin AT<sub>1</sub> receptor inhibitor. [PDF]
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Impact of Prior Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Use on Delirium Incidence in ICU Patients: A Retrospective Study. [PDF]
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Drugs to Slow Progression of Chronic Kidney Disease: It Is a Whole New World!
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The angiotensin II type 1 receptor blocker valsartan attenuates graft vasculopathy
Basic Research in Cardiology, 2004Transplant arteriosclerosis remains the major cause of graft failure after cardiac transplantation. Here, we investigated the effects of the angiotensin II type 1 receptor blocker valsartan on the development of transplant arteriosclerosis in a murine model of cardiac transplantation.Hearts from DBA/2 (H-2(d)) mice were heterotopically transplanted ...
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Effect of angiotensin II type 1 receptor blocker on osteoporotic rat femurs
Pharmacological Reports, 2012Osteoblasts and osteoclasts are known to express Ang II type I (AT1) receptor in cell cultures, suggesting the existence of local renin-angiotensin system (RAS) in bone. This study was designed to investigate the effects of losartan as AT1 receptor blocker on ovariectomized rats' femur.Losartan (5 mg/kg/day) was administered via oral gavage for 8 weeks.
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Abstract: Renin‐angiotensin system blockade retards the progression of diabetic and non‐diabetic chronic kidney disease of the native kidneys. Though most patients suffer from a significant renal insufficiency (chronic kidney disease stage III) and a concomitant heart disease after renal transplantation, there is up to now no evidence supporting the ...
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Angiotensin II Receptor blockers (ARBs) are an important addition to the current range of medications available for treating a wide spectrum of diseases including cardiovascular diseases. Coronary heart disease (CHD) is the most common cause of death in the United Kingdom and worldwide.
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