Results 31 to 40 of about 146,093 (222)

Angiotensin II type 1 receptor blocker telmisartan induces apoptosis and autophagy in adult T‐cell leukemia cells [PDF]

FEBS Open Bio, 2016
Adult T‐cell leukemia/lymphoma (ATL), an aggressive T‐cell malignancy that develops after long‐term infection with human T‐cell leukemia virus (HTLV‐1), requires new treatments. Drug repositioning, reuse of a drug previously approved for the treatment of
Tomohiro Kozako, Shuhei Soeda, Makoto Yoshimitsu, Naomichi Arima, Ayako Kuroki, Shinya Hirata, Hiroaki Tanaka, Osamu Imakyure, Nanako Tone, Shin‐ichiro Honda, Shinji Soeda, Shinji Soeda, Shinji Soeda   +12 more
openalex   +2 more sources

Receptor Interactions of Angiotensin II and Angiotensin Receptor Blockers—Relevance to COVID-19

Biomolecules, 2021
Angiotensin II (Ang II) may contain a charge relay system (CRS) involving Tyr/His/carboxylate, which creates a tyrosinate anion for receptor activation. Energy calculations were carried out to determine the preferred geometry for the CRS in the presence ...
Graham J. Moore, Jose M. Pires, Konstantinos Kelaidonis, Laura Kate Gadanec, Anthony Zulli, Vasso Apostolopoulos, John M. Matsoukas   +6 more
doaj   +1 more source

Association Between Angiotensin II Receptor Blockers and the Risk of Lung Cancer Among Patients With Hypertension From the Korean National Health Insurance Service-National Health Screening Cohort [PDF]

Journal of Preventive Medicine and Public Health, 2020
Objectives: The objective of this study was to estimate the risk of lung cancer in relation to angiotensin II receptor blocker (ARB) use among patients with hypertension from the Korean National Health Insurance Service-National Health Screening Cohort ...
Sungji Moon, Hae-Young Lee, Jieun Jang, Sue K. Park   +3 more
doaj   +1 more source

The angiotensin II type 1 receptor blocker valsartan in the battle against COVID‐19 [PDF]

Obesity, 2021
AbstractObjectiveSevere acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) uses the host’s angiotensin‐converting enzyme 2 (ACE2) as a cellular entry point. Therefore, modulating ACE2 might impact SARS‐CoV‐2 viral replication, shedding, and coronavirus disease 2019 (COVID‐19) severity.
Marlies de Ligt, Matthijs K. C. Hesselink, Johanna Jorgensen, Johan W. E. Jocken, Ellen E. Blaak, Gijs H. Goossens   +5 more
openaire   +3 more sources

Angiotensin II Type I Receptor (AT1R): The Gate towards COVID-19-Associated Diseases

Molecules, 2022
The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its downregulation, which subsequently leads to the dysregulation of the renin–
George El-Arif, Shaymaa Khazaal, Antonella Farhat, Julien Harb, Cédric Annweiler, Yingliang Wu, Zhijian Cao, Hervé Kovacic, Ziad Abi Khattar, Ziad Fajloun, Jean-Marc Sabatier   +10 more
doaj   +1 more source

Angiotensin Receptor Blocker Protection Against Podocyte-Induced Sclerosis Is Podocyte Angiotensin II Type 1 Receptor-Independent [PDF]

Hypertension, 2010
In the present study, we tested the hypothesis that the renoprotective effect of an angiotensin receptor blocker depends on the angiotensin II type 1 (AT 1 ) receptor on podocytes. For this purpose, we generated podocyte-specific knockout mice for the AT 1 gene ( Agtr1a
Taiji, Matsusaka, Takako, Asano, Fumio, Niimura, Masaru, Kinomura, Akihiro, Shimizu, Ayumi, Shintani, Ira, Pastan, Agnes B, Fogo, Iekuni, Ichikawa   +8 more
openaire   +2 more sources

The fourth-generation Calcium channel blocker: Cilnidipine

Indian Heart Journal, 2013
Several classes of antihypertensive agents have been in clinical use, including diuretics, α-blockers, β-blockers, angiotensin converting enzyme (ACE) inhibitors, angiotensin II type 1 receptor blockers (ARB), and organic calcium channel blockers (CCBs).
K. Sarat Chandra, G. Ramesh
doaj   +1 more source

Angiotensin II type 1 receptor blocker attenuates diabetes-induced atrial structural remodeling [PDF]

Journal of Cardiology, 2011
Diabetes mellitus promotes atrial structural remodeling, thereby producing atrial arrhythmogenicity, where advanced glycation endproducts (AGEs) and their receptor (RAGE) are implicated to play a role in the pathogenesis.We investigated the effects of candesartan, an angiotensin type II receptor blocker, on the diabetes-induced atrial structural change.
Kato, Takeshi, Yamashita, Takeshi, Sekiguchi, Akiko, Tsuneda, Takayuki, Sagara, Kouichi, Takamura, Masayuki, Kaneko, Shuichi, Aizawa, Tadanori, Fu, Long-Tai   +8 more
openaire   +2 more sources

An update of medical care in Marfan syndrome

Tzu Chi Medical Journal, 2022
Marfan syndrome (MFS), a multisystemic connective disorder, caused by fibrillin 1 gene mutations with autosomal dominant inheritance. The disease spectrum is wide and the major causes of death are related to aortic root aneurysm or dissection.
Hsin-Hui Chiu
doaj   +1 more source

Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis [PDF]

Hepatology, 2007
Nonalcoholic steatohepatitis (NASH) is now the most frequent cause of chronic liver impairment in developed countries and is a suggested causative factor in the development of cryptogenic cirrhosis and hepatocellular carcinoma.
Akira, Hirose, Masafumi, Ono, Toshiji, Saibara, Yasuko, Nozaki, Kosei, Masuda, Akemi, Yoshioka, Masaya, Takahashi, Naoaki, Akisawa, Shinji, Iwasaki, Jude A, Oben, Saburo, Onishi   +10 more
openaire   +2 more sources