The potential therapeutic use of renin-angiotensin system inhibitors in the treatment of inflammatory diseases [PDF]
, 2019 Inflammation is a normal part of the immune response to injury or infection but its dysregulation promotes the development of inflammatory diseases, which cause considerable human suffering.
Avan, Amir +5 more
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Frontiers in Cellular and Infection Microbiology, 2021 Several comorbidities, including hypertension, have been associated with an increased risk of developing severe disease during SARS-CoV-2 infection. Angiotensin II receptor blockers (ARBs) are currently some of the most widely-used drugs to control blood
Gabriel Augusto Pires de Souza +14 more
doaj +1 more source
Pharmacological effects of raas blockade in ischemic nephropathy [PDF]
, 2016 Background: The management of ischemic nephropathy due to atherosclerotic renal artery stenosis has become increasingly conservative in the modern era, with current guidelines recommending optimized medical therapy as the initial step.
Barbano, Biagio +8 more
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The Impact of Age-Related Dysregulation of the Angiotensin System on Mitochondrial Redox Balance
Frontiers in Physiology, 2014 Aging is associated with the accumulation of various deleterious changes in cells. According to the free radical and mitochondrial theory of aging, mitochondria initiate most of the deleterious changes in aging and govern life span.
Ramya eVajapey +3 more
doaj +1 more source
Monotherapy with major antihypertensive drug classes and risk of hospital admissions for mood disorders [PDF]
, 2016 Major depressive and bipolar disorders predispose to atherosclerosis, and there is accruing data from animal model, epidemiological, and genomic studies that commonly used antihypertensive drugs may have a role in the pathogenesis or course of mood ...
Boal, Angela H. +6 more
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Advances in the Renin-Angiotensin-Aldosterone System: Relevance to Diabetic Nephropathy
The Scientific World Journal, 2008 Hypertension is now recognized as a key contributory factor to the development and progression of kidney disease in both type 1 and type 2 diabetes. The renin angiotensin system (RAS) and its effector molecule angiotensin II, in particular, have a range ...
Audrey Koitka, Christos Tikellis
doaj +1 more source
Emerging pharmacological treatments to prevent abdominal aortic aneurysm growth and rupture [PDF]
, 2015 Abdominal aortic aneurysm (AAA) is a local expansion of the abdominal aorta wall caused by a complex multifactorial maladaptive vascular remodeling. Despite recent advances in the management of cardiovascular diseases, there currently is no established ...
Fraga-Silva, Rodrigo +2 more
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Angiotensin II facilitates fibrogenic effect of TGF-β1 through enhancing the down-regulation of BAMBI caused by LPS: a new pro-fibrotic mechanism of angiotensin II. [PDF]
PLoS ONE, 2013 Angiotensin II has progressively been considered to play an important role in the development of liver fibrosis, although the mechanism isn't fully understood.
Yu-Sheng Li +6 more
doaj +1 more source
The Role of Renin–Angiotensin System in Diabetic Cardiomyopathy: A Narrative Review
Life, 2023 Diabetic cardiomyopathy refers to myocardial dysfunction in type 2 diabetes, but without the traditional cardiovascular risk factors or overt clinical atherosclerosis and valvular disease.
João Pedro Thimotheo Batista +3 more
doaj +1 more source
Exploring metabolic dysfunction in chronic kidney disease [PDF]
, 2012 Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and end-stage renal disease (ESRD) is a serious medical condition associated with increased morbidity, mortality, and in particular cardiovascular disease (CVD) risk ...
Slee, Adrian D.
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