Results 41 to 50 of about 77,701 (209)

Atenolol versus losartan in children and young adults with Marfan's syndrome [PDF]

, 2014
BACKGROUND : Aortic-root dissection is the leading cause of death in Marfan's syndrome. Studies suggest that with regard to slowing aortic-root enlargement, losartan may be more effective than beta-blockers, the current standard therapy in most centers.
Atz, A.M., Backer, J. de, Benson, D.W., Bradley, T.J., Braverman, A.C., Chen, S., Colan, S.D., Dietz, H.C., et al., Gelb, B.D., Grossfeld, P.D., Klein, G.L., Lacro, R.V., Lai, W.W., Levine, J.C., Liou, A., Loeys, B.L., Mahony, L., Markham, L.W., Olson, A.K., Paridon, S.M., Pearson, G.D., Pemberton, V.L., Pierpont, M.E., Pyeritz, R.E., Radojewski, E., Roman, M.J., Sharkey, A.M., Sleeper, L.A., Stylianou, M.P., Tierney, E.S., Wechsler, S.B., Yetman, A.T., Young, L.T.   +33 more
core   +4 more sources

Blockade of Mas Receptor or Mas-Related G-Protein Coupled Receptor Type D Reduces Portal Pressure in Cirrhotic but Not in Non-cirrhotic Portal Hypertensive Rats

Frontiers in Physiology, 2019
Portal hypertension (PHT) resulting from splanchnic vasodilatation is a major cause of morbidity and mortality in patients with cirrhosis. The renin-angiotensin system (RAS) plays an important role in splanchnic vasodilatation in cirrhosis.
Lakmie S. Gunarathne, Peter W. Angus, Peter W. Angus, Chandana B. Herath   +3 more
doaj   +1 more source

Significance of angiotensin II receptor blockers with high affinity to angiotensin II type 1 receptors for vascular protection in rats [PDF]

Hypertension Research, 2009
Angiotensin II receptor blockers (ARBs) vary in their binding affinities to angiotensin II type 1 (AT(1)) receptors in in vitro experiments. We compared a high-affinity ARB, olmesartan, and a low-affinity ARB, valsartan, in terms of their vascular protective effects in stroke-prone spontaneously hypertensive rats (SHR-SP).
Shinji, Takai, Denan, Jin, Hironobu, Ikeda, Hiroshi, Sakonjo, Mizuo, Miyazaki   +4 more
openaire   +2 more sources

Olmesartan potentiates the anti-angiogenic effect of sorafenib in mice bearing Ehrlich's ascites carcinoma: role of angiotensin (1-7). [PDF]

PLoS ONE, 2014
Local renin-angiotensin systems exist in various malignant tumor tissues; this suggests that the main effector peptide, angiotensin II, could act as a key factor in tumor growth.
Mohammad M Abd-Alhaseeb, Sawsan A Zaitone, Soad H Abou-El-Ela, Yasser M Moustafa   +3 more
doaj   +1 more source

A network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure [PDF]

, 2019
Aims Heart failure (HF) is frequently caused by an ischaemic event (e.g. myocardial infarction) but might also be caused by a primary disease of the myocardium (cardiomyopathy).
Anker, Stefan D., Cleland, John G. F., Dickstein, Kenneth, Hillege, Hans L., Lam, Carolyn S. P., Lang, Chim C., Metra, Marco, Nauta, Jan F., Ng, Leong L., Romaine, Simon P. R., Sama, Iziah E., Samani, Nilesh J., Ter Maaten, Jozine M., Tromp, Jasper, van der Meer, Peter, van Veldhuisen, Dirk J., Voors, Adriaan A., Woolley, Rebecca J., Zannad, Faiez   +18 more
core   +5 more sources

Diminazene Aceturate Reduces Angiotensin II Constriction and Interacts with the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2

Biomedicines, 2022
Diminazene aceturate (DIZE) is a putative angiotensin-converting enzyme 2 (ACE2) activator and angiotensin type 1 receptor antagonist (AT1R). Its simple chemical structure possesses a negatively charged triazene segment that is homologous to the ...
John M. Matsoukas, Laura Kate Gadanec, Anthony Zulli, Vasso Apostolopoulos, Konstantinos Kelaidonis, Irene Ligielli, Kalliopi Moschovou, Nikitas Georgiou, Panagiotis Plotas, Christos T. Chasapis, Graham Moore, Harry Ridgway, Thomas Mavromoustakos   +12 more
doaj   +1 more source

Therapeutic potential of the renin angiotensin system in ischaemic stroke [PDF]

, 2016
The renin angiotensin system (RAS) consists of the systemic hormone system, critically involved in regulation and homeostasis of normal physiological functions [i.e.
Arroja, Mariana Moreira Coutinho, McCabe, Christopher, Reid, Emma   +2 more
core   +1 more source

Loss of angiotensin II receptor expression in dopamine neurons in Parkinson’s disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation [PDF]

, 2015
In rodent models of Parkinsons disease (PD), dopamine neuron loss is accompanied by increased expression of angiotensin II (AngII), its type 1 receptor (AT1), and NADPH oxidase (Nox) in the nigral dopamine neurons and microglia.
Aboud, O, Biedermann, J, Gentleman, SM, Griffin, WS, Mrak, RE, Palmer, QD, Zawada, WM   +6 more
core   +2 more sources

Comparison of different strategies to measure medication adherence via claims data in patients with chronic heart failure [PDF]

, 2019
Medication adherence correlates with morbidity and mortality in patients with chronic heart failure (CHF), but is difficult to assess. We conducted a retrospective methodological cohort study in 3,808 CHF patients, calculating adherence as proportion of ...
Griese‐Mammen, Nina, Ihle, Peter, Krueger, Katrin, Laufs, Ulrich, Parrau, Natalie, Schubert, Ingrid, Schulz, Martin   +6 more
core   +1 more source

Impact of age on characteristics, performance measures and outcomes of inpatients for heart failure in Beijing, China

ESC Heart Failure, 2023
Aims This study aims to provide representative information on heart failure (HF) patients in China, especially older adults aged ≥75 years. We aim to clarify the age‐related discrepancies in performance measures and the modifying effect of age on the ...
Cong Yuan, Liu He, Xin Du, Chao Jiang, Shi‐Jun Xia, Xin Zhao, Song‐Nan Li, Cai‐Hua Sang, De‐Yong Long, Jian‐Zeng Dong, Chang‐Sheng Ma   +10 more
doaj   +1 more source