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Protecting glomerulus: role of angiotensin-II type 2 receptor
Clinical Science, 2022Abstract Podocyte injury due to either drug, toxin, infection, or metabolic abnormality is a great concern as it increases the risk of developing focal segmental glomerulosclerosis (FSGS) and proteinuric kidney diseases. The direct podocyte injury due to doxorubicin is associated with an increase in proinflammatory cytokines and ...
Sanket Patel +2 more
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Vascular angiotensin II actions mediated by angiotensin II type 2 receptors
Current Hypertension Reports, 2004Angiotensin II (Ang II) is the major effector peptide of the renin-angiotensin system and acts at two major receptors known as Ang II type 1 receptor (AT(1)R) and Ang II type 2 receptor (AT(2)R). Increasingly, there is evidence suggesting that the AT(2)R counter-regulates the excitatory effects of AT(1)R stimulation.
Ruth E, Hannan, Robert E, Widdop
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Hypertension, 2012 The renin-angiotensin system regulates cardiovascular physiology via angiotensin II engaging the angiotensin type 1 or type 2 receptors. Classic actions are type 1 receptor mediated, whereas the type 2 receptor may counteract type 1 receptor activity ...
Mónica Flores-Muñoz +2 more
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Angiotensin II Type 1 and Type 2 Receptor-induced Cell Signaling
Current Pharmaceutical Design, 2013The octapeptide angiotensin II (Ang II) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and also contributes to the progression of cardiovascular remodeling. Ang II activates Ang II type 1 (AT1) receptor and type 2 (AT2) receptor, both of which belong to the seven-transmembrane, G protein-coupled receptor
Hiroshi, Akazawa +4 more
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SHEEP HYPOTHALAMUS CONTAINS A NON‐ANGIOTENSIN LIGAND FOR TYPE 1 AND TYPE 2 ANGIOTENSIN II RECEPTORS
Clinical and Experimental Pharmacology and Physiology, 1993SUMMARY1. The aim of this study was to determine whether the brain contains an alternative ligand for angiotensin II (AII) receptors.2. A radioreceptor assay based upon bovine cerebellar membranes (Type 2 AII receptors) was used to monitor the partial purification of an AII‐like material from sheep hypothalami.3.
J, Blasioli +3 more
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Annals of Biomedical Engineering, 2000
Numerous studies have demonstrated changes in receptor number, protein concentration, or mRNA levels and have proposed that these subcellular changes produce physiologic effects. To date, no adequate mathematical analysis has been available to provide a framework for interpretation of such data.
E H, Nora, P J, Tonellato, A S, Greene
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Numerous studies have demonstrated changes in receptor number, protein concentration, or mRNA levels and have proposed that these subcellular changes produce physiologic effects. To date, no adequate mathematical analysis has been available to provide a framework for interpretation of such data.
E H, Nora, P J, Tonellato, A S, Greene
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General Pharmacology: The Vascular System, 1998
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V, Goutsouliak, S W, Rabkin
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V, Goutsouliak, S W, Rabkin
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Endocrinology, 1999
The regulatory effects of angiotensin-II (AngII) and several growth factors, including insulin-like growth factor 1 (IGF-1), basic fibroblast growth factor (bFGF), and transforming growth factor beta1 (TGFbeta1) on the AngII subtype 2 (AT2) receptor were studied using R3T3 cells, a mouse fibroblast cell line that expresses only AT2 receptors.
Li, J.Y. +4 more
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The regulatory effects of angiotensin-II (AngII) and several growth factors, including insulin-like growth factor 1 (IGF-1), basic fibroblast growth factor (bFGF), and transforming growth factor beta1 (TGFbeta1) on the AngII subtype 2 (AT2) receptor were studied using R3T3 cells, a mouse fibroblast cell line that expresses only AT2 receptors.
Li, J.Y. +4 more
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Angiotensin II Type 2 Receptor (AT2R) in Glomerulogenesis
2019Les données épidémiologiques indiquent que le diabète maternel est associé de manière significative aux anomalies congénitales des reins et des voies urinaires (CAKUT), ce qui implique un risque accru de CAKUT chez la progéniture des mères diabétiques par rapport à la population globale.
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