Results 11 to 20 of about 8,783 (159)

Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin type 2 receptor. [PDF]

PLoS ONE, 2012
The counter-regulatory axis of the renin angiotensin system peptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a potential therapeutic target in cardiac remodelling, acting via the mas receptor.
Monica Flores-Muñoz, Bruno M D C Godinho, Abdulaziz Almalik, Stuart A Nicklin   +3 more
doaj   +3 more sources

ANGIOTENSIN II RECEPTOR TYPE 1 EXPRESSION IN PATIENTS WITH MULTIFOCAL ATHEROSCLEROSIS

Российский кардиологический журнал, 2016
Local expression of rennin-angiotensin system (RAS) components significantly increases in patients with arterial hypertension and atherosclerosis with or without elevation of RAS activity in the blood.
I. S. Mykhailichenko
doaj   +3 more sources

Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis

American Journal of Physiology-Renal Physiology, 2010
Angiotensin type 1 (AT1) receptor blocker (ARB) ameliorates progression of chronic kidney disease. Whether this protection is due solely to blockade of AT1, or whether diversion of angiotensin II from the AT1to the available AT2receptor, thus potentially enhancing AT2receptor effects, is not known.
Takashi, Naito, Li-Jun, Ma, Haichun, Yang, Yiqin, Zuo, Yiwei, Tang, Jee Young, Han, Valentina, Kon, Agnes B, Fogo   +7 more
openaire   +4 more sources

Characterization of a mutant type-1 angiotensin II receptor

Kidney International, 1994
We have used PCR to amplify the rat AT1 receptor from liver mRNA. The receptor DNA was subcloned into pcDNAI and a number of individual clones were transiently expressed in COS-7 cells. These individual receptors were characterized by binding of [125I] Sar1, Ile8-angiotensin II.
Roche, Peter J., Eddie, Lawrence W., Coghlan, John P.   +2 more
openaire   +3 more sources

Electronic sculpting of ligand-GPCR subtype selectivity:the case of angiotensin II [PDF]

, 2014
GPCR subtypes possess distinct functional and pharmacological profiles, and thus development of subtype-selective ligands has immense therapeutic potential.
Pappas, Charalampos G., Francesca Magnani, Jones, Emma S., Gerothanassis, Ioannis P., Emma S. Jones, Andreas G. Tzakos, Widdop, Robert E., Crook, Tim, Ishiguro, Susumu, Charalampos G. Pappas, Vassiliki Magafa, Tzakos, Andreas G., Naomi Ohta (735090), Jana Selent, Paul Cordopatis, Susumu Ishiguro, Ioannis P. Gerothanassis, Ohta, Naomi, Andreas G. Tzakos (1327620), Tim Crook, Naomi Ohta, Francesca Magnani (1327608), Ioannis P. Gerothanassis (1327626), Masaaki Tamura, Paul Cordopatis (1327614), Cordopatis, Paul, Sanja Bosnyak, Jana Selent (147923), Emma S. Jones (1327623), Robert E. Widdop (585063), Selent, Jana, Bosnyak, Sanja, Magnani, Francesca, Robert E. Widdop, Charalampos G. Pappas (1327617), Susumu Ishiguro (735091), Vassiliki Magafa (1327629), Sanja Bosnyak (1327611), Tamura, Masaaki, Masaaki Tamura (735096), Magafa, Vassiliki, Tim Crook (1069)   +41 more
core   +1 more source

Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo [PDF]

, 2004
<b>Background</b> From in vitro studies, it has become clear that several signaling cascades are involved in angiotensin II-induced cellular hypertrophy.
Martens Fabrice MAC, Fabrice MAC Martens, Touyz, R.M., Daigle, Christine, Martens, Fabrice, Touyz Rhian M, Dao Huy, Christine Daigle, Huy Hao Dao, Daphné Girardot, Rhian M Touyz, Moreau Pierre, Girardot, D., Daigle, C., Dao, H., Moreau, P., Girardot, Daphné, Martens, F.M.A.C., Dao, Huy, Daigle Christine, Moreau, Pierre, Girardot Daphné, Pierre Moreau, Touyz, Rhian   +23 more
core   +1 more source

Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy [PDF]

, 2007
Maternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor.
Kellems, Rodney E., Kellems, Rodney E, Mi, TieJuan, Xia, Yang, Sun, C, Hewett, Peter W, Abbasi, S, Zhou, CC, Mi, T, Abbasi, Shahrzad, Hewett, Peter, Xia, Y, Sun, ChunXiao, Kellems, RE, Ahmed, Asif, Hewett, Peter W., Xia, L, Ahmad, Shakil, Xia, Lingwei, Zhou, Cissy Chenyi   +19 more
core   +1 more source

Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThe classical renin‐angiotensin system is known as the angiotensin (Ang)‐converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline.
Akinori Higaki, Masaki Mogi, Jun Iwanami, Li‐Juan Min, Hui‐Yu Bai, Bao‐Shuai Shan, Masayoshi Kukida, Toshifumi Yamauchi, Kana Tsukuda, Harumi Kan‐no, Shuntaro Ikeda, Jitsuo Higaki, Masatsugu Horiuchi   +12 more
doaj   +1 more source

Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?

Frontiers in Pharmacology, 2020
G-protein–coupled receptors (GPCRs) are targets for around one third of currently approved and clinical prescribed drugs and represent the largest and most structurally diverse family of transmembrane signaling proteins, with almost 1000 members ...
Natalia L. Rukavina Mikusic, Mauro G. Silva, Angélica M. Pineda, Mariela M. Gironacci   +3 more
doaj   +1 more source

Angiotensin II modulates THP-1-like macrophage phenotype and inflammatory signatures via angiotensin II type 1 receptor

Frontiers in Cardiovascular Medicine, 2023
Angiotensin II (Ang II) is a major component of the renin–angiotensin or renin–angiotensin–aldosterone system, which is the main element found to be involved in cardiopathology.
Tlili Barhoumi, Fatmah A. Mansour, Maroua Jalouli, Hassan S. Alamri, Rizwan Ali, Abdel Halim Harrath, Maha Aljumaa, Mohamed Boudjelal   +7 more
doaj   +1 more source