Results 51 to 60 of about 8,783 (159)

Angiotensin-(1–7) suppresses pyroptosis in cerebral endothelium to decrease blood–brain barrier permeability and cognitive impairments in sepsis

Journal of International Medical Research
Objective This study aimed to explore the influence of the angiotensin-(1–7)/Mas receptor and angiotensin II/angiotensin II type 1 receptor pathways on pyroptosis during sepsis and their subsequent effects on cognitive function.
Yongli Han, Hongguang Ding, Yirun Chen, Yin Wen, Huishan Zhu, Zhiwei Su, Jiaqi Tang, Hongke Zeng   +7 more
doaj   +1 more source

Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease

Clinical and Experimental Hypertension, 2018
Renin angiotensin system (RAS) is an endogenous hormone system involved in the control of blood pressure and fluid volume. Dysregulation of RAS has a pathological role in causing cardiovascular diseases through hypertension.
Misbah Hussain, Fazli Rabbi Awan
doaj   +1 more source

Angiotensin Converting Enzyme and Angiotensin II Type 1 Receptor Polymorphisms in Patients with Coronary Aneurysms

Thrombosis Journal, 2003
Background Conflicting results have been reported regarding the association of gene polymorphisms in the renin-angiotensin system (RAS) with different aspects of coronary artery disease (CAD), such as myocardial infarction, neointimal hyperplasia or ...
Helbecque Nicole, Lablanche Jean-Marc, Hermant Xavier, Lamblin Nicolas, Amouyel Philippe, Bauters Christophe   +5 more
doaj   +1 more source

Angiotensin II Type 1 Receptor‐Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe kidney is easily affected by aging‐associated changes, including glomerulosclerosis, tubular atrophy, and interstitial fibrosis. Particularly, renal tubulointerstitial fibrosis is a final common pathway in most forms of progressive renal ...
Kazushi Uneda, Hiromichi Wakui, Akinobu Maeda, Kengo Azushima, Ryu Kobayashi, Sona Haku, Kohji Ohki, Kotaro Haruhara, Sho Kinguchi, Miyuki Matsuda, Masato Ohsawa, Shintaro Minegishi, Tomoaki Ishigami, Yoshiyuki Toya, Yoshitoshi Atobe, Akio Yamashita, Satoshi Umemura, Kouichi Tamura   +17 more
doaj   +1 more source

Advances in the Renin-Angiotensin-Aldosterone System: Relevance to Diabetic Nephropathy

The Scientific World Journal, 2008
Hypertension is now recognized as a key contributory factor to the development and progression of kidney disease in both type 1 and type 2 diabetes. The renin angiotensin system (RAS) and its effector molecule angiotensin II, in particular, have a range ...
Audrey Koitka, Christos Tikellis
doaj   +1 more source

Acute kidney injury: an acceptable risk of treatment with renin-angiotensin system blockade in primary care? [PDF]

, 2015
Background: Use of renin-angiotensin system (RAS) blockade has become increasingly widespread driven by evidence-based guidance. There is concern about the role of these agents in the genesis of avoidable acute kidney injury (AKI).
Jean Irving, Paul E Stevens, Irving, Jean, Michael Bedford, Bedford, Michael, Stevens, Paul E., Christopher KT Farmer, Farmer, Christopher K.   +7 more
core   +1 more source

Impaired endothelial function of the retinal vasculature in hypertensive patients [PDF]

, 2004
<p><b>Background and Purpose:</b> Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation.</p> <p ...
Michelson, G., Hilgers, K.F., Oehmer, S., Harazny, J., Delles, C., Schmieder, R.E.   +5 more
core   +1 more source

Angiotensin II Type 1 Receptor Antagonist Losartan Inhibits TNF-α-Induced Inflammation and Degeneration Processes in Human Nucleus Pulposus Cells [PDF]

, 2021
Our recent study detected the expression of a tissue renin–angiotensin system (tRAS) in human intervertebral discs (IVDs). The present study sought to investigate the impact of the angiotensin II receptor type 1 (AGTR1) antagonist losartan on human ...
Saravi, Babak E., Li, Zhen, Wystrach, Laura, Lang, Gernot, Robert Geoffrey Richards, Albers, Christoph E., Mauro Alini, Albers, Christoph E, Häckel, Sonja, Zhen Li, Wystrach, Laura Wanda, Saravi, Babak, Babak Saravi, Pfannkuche, Judith, Lang, Corinna N., Schmal, Hagen, Norbert Südkamp, Sonja Häckel, Laura Wystrach, Judith Pfannkuche, Alini, Mauro, Gernot Lang, Südkamp, Norbert, Richards, Robert Geoffrey, Sibylle Grad, Christoph E. Albers, Lang, Corinna, Hagen Schmal, Grad, Sibylle, Corinna Lang, Pfannkuche, Judith-J.   +30 more
core   +1 more source

Angiotensin II type 1 receptor antagonists and their combinations in the treatment of hypertension

South African Family Practice, 2012
No abstract available.
J.A. Ker
doaj   +1 more source

The Angiotensin II Type 1 Receptor-Associated Protein Attenuates Angiotensin II-Mediated Inhibition of the Renal Outer Medullary Potassium Channel in Collecting Duct Cells

Frontiers in Physiology, 2021
Adjustments in renal K+ excretion constitute a central mechanism for K+ homeostasis. The renal outer medullary potassium (ROMK) channel accounts for the major K+ secretory route in collecting ducts during basal conditions.
Juliano Zequini Polidoro, Nancy Amaral Rebouças, Adriana Castello Costa Girardi   +2 more
doaj   +1 more source