Results 181 to 190 of about 8,972 (208)

Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2009
Item does not contain fulltextOBJECTIVE: Plasma lipoprotein levels are determined by the balance between lipoprotein production and clearance. Recently, angiopoietin-like protein 4 (ANGPTL4) was uncovered as a novel endocrine factor that potently raises ...
Sander Kersten, Laeticia Lichtenstein, Patrick Schrauwen   +2 more
exaly   +2 more sources

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ANGPTL4: a new mode in the regulation of intravascular lipolysis

Current Opinion in Lipidology, 2021
Purpose of review Lipoprotein lipase (LPL) is the rate-limiting enzyme for intravascular processing of circulating triglyceride-rich lipoproteins (TRLs). One emerging strategy for therapeutic lowering of plasma triglyceride levels aims at increasing the longevity of LPL activity by attenuating its inhibition from angiopoietin ...
openaire   +3 more sources

ANGPTL4-the Link Binding Lipid Metabolism and Inflammation

Current Medicinal Chemistry
Background: Angiopoietin-like 4 (ANGPTL4) belongs to the family of angiopoietin- like proteins. The involvement of ANGPTL4 in various aspects of lipid metabolism and inflammation has become an important area of research. Methods: A thorough search on PubMed related to ANGPTL4, lipid metabolism, and inflammation was performed.
Yueqi Zhang, Jingwen Liang
exaly   +3 more sources

ANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis

Current Opinion in Hematology, 2020
Purpose of review Since the first discovery of Angiopoetin-like 4 (ANGPTL4) in 2000, the involvement of ANGPTL4 in different aspects of lipid metabolism and vascular biology has emerged as an important research field. In this review, we summarize the fundamental roles of ANGPTL4 in regulating metabolic and nonmetabolic ...
Carlos, Fernández-Hernando, Yajaira, Suárez   +1 more
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Friend or foe? The elusive role of ANGPTL4 in inflammation

Cell Signaling, 2023
Angiopoietin-like 4 (ANGPTL4) belongs to the angiopoietin-like protein family and mediates the inhibition of lipoprotein lipase activity. Emerging evidence suggests that ANGPTL4 has pleiotropic functions with anti- and pro-inflammatory properties. Here, we have reviewed the research progress on ANGPTL4 and systematically discussed the dual role of ...
Yuyue Zuo, Yueqi Zhang, Lei Dai
openaire   +1 more source

Angiopoietin-like protein 4(E40K) and ANGPTL4/8 complex have reduced, temperature-dependent LPL-inhibitory activity compared to ANGPTL4

Biochemical and Biophysical Research Communications, 2021
We previously demonstrated that angiopoietin-like 8 (ANGPTL8) forms a localized complex with ANGPTL4 to reduce its lipoprotein lipase (LPL)-inhibitory activity and enable increased postprandial uptake of fatty acids (FA) into adipose tissue. Because prolonged cold exposure may increase adipose tissue FA uptake and decrease circulating triglycerides (TG)
Yan Q. Chen, Thomas G. Pottanat, Robert W. Siegel, Mariam Ehsani, Yue-Wei Qian, William C. Roell, Robert J. Konrad   +6 more
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PM2.5 induces lung inflammation through ANGPTL4

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Fine particulate matter (PM2.5) is a common major air pollutant associated with decreased lung function, induced allergic airway inflammation closely correlated with chronic lung diseases. Angiopoietin-like protein 4 (ANGPTL4) is a cytokine with multiple functions, participating in processes such as inflammation, angiogenesis, and metastasis.
Yeak-Wun, Quek, Yu-Ting, Kang, Hsu Chih, Huang, Hui-Yi, Chang, I-Chieh, Huang, Ko-Huang, Lue, Jiunn-Liang, Ko   +6 more
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Promising Role of ANGPTL4 Gene in Diabetic Wound Healing

The International Journal of Lower Extremity Wounds, 2014
Diabetes mellitus (DM) is one of the severe metabolic disorders of carbohydrate metabolism worldwide. Developing countries are at higher risk of DM, and there is significant evidence that it is epidemic in many economically developing and newly industrialized countries.
Awadhesh K, Arya, Kamlakar, Tripathi, Parimal, Das   +2 more
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Regulation of plasma triglycerides by ANGPTL4 and GPIHBP1

2018
<p>The absorption, packaging, and delivery of fat to appropriate peripheral tissues is essential for maintaining metabolic homeostasis, and defects or dysregulation of these processes can contribute to metabolic disorders such as diabetes, obesity, and hyperlipidemia.
Emily Malcolm Cushing, Brandon S.J. Davies, Sheila Baker, Eric Taylor, Matthew Potthoff, Kris DeMali, Andrew Norris   +6 more
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Angiopoietin-Like 4 (Angptl4) in MCNS

2016
Minimal-change nephrotic syndrome (MCNS) affects children and adults, with onset most commonly seen between ages 2 and 10 years. The cardinal characteristics of this disease include massive and selective proteinuria, normal-appearing glomeruli on light microscopy, diffuse effacement of podocyte foot processes on electron microscopy, loss of glomerular ...
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